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Review Article

基于纳米技术的神经退行性疾病的目标：有效提供神经医学的有前途的工具。

卷 21, 期 8, 2020

页: [819 - 836] 页: 18

弟呕挨: 10.2174/1389450121666200106105633

价格: $65

摘要

传统的药物递送方法仍然不能有效地为各种神经退行性疾病（ND）提供更好的治疗。在这种情况下，各种类型的纳米载体已显示出跨越血脑屏障（BBB）的巨大潜力，并已成为药物递送中的重要载体系统。此外，基于纳米技术的方法通常涉及许多纳米级载体平台，这些平台可增强治疗剂在ND治疗中的作用，特别是在诊断和药物输送中，副作用可忽略不计。此外，基于纳米技术的技术提供了几种穿越血脑屏障的策略，以增强大脑中药物部分的生物利用度。在最近几年中，通过掺入各种生物相容性成分（例如，基于多糖的NP，聚合物NP，硒NP，AuNP，基于蛋白质的NP，g NP等），开发了各种纳米颗粒（NP）。对NDs表现出极大的治疗作用。最终，这篇综述提供了深刻的见解，以探索一些创新的纳米载体的应用，这些载体将活性分子包裹在ND的有效治疗中。

关键词: 神经退行性疾病，β淀粉样蛋白肽，帕金森氏病，纳米颗粒，纳米技术，阿尔茨海默氏病。

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