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当代阿耳茨海默病研究

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ISSN (Print): 1567-2050
ISSN (Online): 1875-5828

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Systematic Review Article

痴呆症的中年可调整危险因素：34项前瞻性队列研究的系统评价和荟萃分析

卷 16, 期 14, 2019

页: [1254 - 1268] 页: 15

弟呕挨: 10.2174/1567205017666200103111253

价格: $65

摘要

目的：本研究的目的是评估中年危险因素与痴呆之间的关系。 方法：于2018年5月24日对PubMed和Cochrane库进行系统搜索，以检索前瞻性队列研究。通过随机效应模型计算了相对危险度（RR）和95％置信区间（CI），以探讨中年危险因素与痴呆之间的关系。进行了敏感性分析和元回归，以探索异质性的来源。使用Begg和Egger的检验检查了出版偏倚。 结果：纳入了34项前瞻性队列研究，其中24项符合条件进行了荟萃分析。 65岁之前，共有159,594名非痴呆症成年人入选基线，随访后被诊断患有痴呆症的人数为13,540人。汇总结果显示，五个因素可将痴呆症风险显着增加41％至78％，其中包括肥胖（RR，1.78； 95％CI：1.31-2.41），糖尿病（RR，1.69； 95％CI：1.38-2.07）。 ，目前吸烟（RR，1.61; 95％，CI：1.32-1.95），高胆固醇血症（RR，1.57; 95％CI：1.19-2.07）和高血压（边界血压RR，1.41; 95％CI：1.23-1.62）和高收缩压（SBP）RR，1.72； 95％CI：1.25-2.37）。但是，敏感性分析发现高胆固醇血症和高SBP的结果不可靠，这需要更多高质量的研究来证实。没有发现由于出版偏见造成的影响。在系统评价中，发现另外三个因素（高同型半胱氨酸血症，心理压力和大量饮酒）与痴呆症风险升高有关。此外，体育锻炼，健康饮食和中年激素治疗与降低痴呆症风险有关。 结论：肥胖，糖尿病，高血压或高胆固醇血症的中年人以及中年吸烟者在以后的生活中罹患痴呆症的风险较高。

关键词: 痴呆症，荟萃分析，中年危险因素，系统评价，前瞻性队列研究，亚组分析。

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