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当代肿瘤药物靶点

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ISSN (Print): 1568-0096
ISSN (Online): 1873-5576

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Mini-Review Article

Idronoxil（伊曲诺昔）作为一种抗癌剂:活性和机制

卷 20, 期 5, 2020

页: [341 - 354] 页: 14

弟呕挨: 10.2174/1568009620666200102122830

价格: $65

摘要

在过去的二十年里，伊曲诺昔已经成为50多份同类综述出版物的主题。这种异黄酮是一种有趣的调节多种信号转导途径，能够引起一系列的生物效应，包括细胞周期阻滞，凋亡，刺激免疫系统的能力，和抑制血管生成。这些多方面的作用表明，伊曲诺昔具有与广泛的癌症治疗协同或补充的潜力。虽然过去曾进行过临床试验，但由于静脉或口服给药时人体生物利用度低，对伊曲诺昔的研究已经中止，尽管克服这一问题的策略目前正在探索中。在此，我们总结了目前有关伊曲诺昔的关键细胞靶点的文献，以及伊曲诺昔发挥其抗癌作用的机制，为给予这种独特的分子第二次机会为未来的癌症治疗做出贡献奠定了新的基础。

关键词: Idronoxil

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图形摘要

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