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Mini-Review Article

β细胞簇中主要的microRNA用于胰岛素调节和糖尿病控制。

卷 21, 期 7, 2020

页: [722 - 734] 页: 13

弟呕挨: 10.2174/1389450121666191230145848

价格: $65

摘要

微小（mi）-RNA是多个过程的重要调节剂，包括胰岛素信号传导途径和葡萄糖代谢。胰腺β细胞的功能取决于某些miRNA及其靶mRNA，它们共同形成一个复杂的调节网络。已知有几种miRNA直接参与β细胞功能，例如胰岛素表达和分泌。这些小RNA也可能在β细胞的命运中发挥重要作用，例如增殖，分化，存活和凋亡。在miRNA中，由于在这些细胞中高表达，miR-7，miR-9，miR-375，miR-130和miR-124引起了人们的特别关注。在糖尿病条件下，尽管未观察到特定的miRNA谱，但转录后机制改变了某些miRNA及其靶mRNA的表达，在各种糖尿病并发症的病理生物学过程中发挥了不同的作用。这篇综述文章的目的是讨论参与干细胞分化为β细胞的过程中的miRNA，从而导致针对糖尿病疾病的β细胞功能增强。本文还将探讨miRNA表达模式对β细胞体外增殖和分化的影响。还将讨论计算基因组学和生化分析将干细胞衍生的β细胞的miRNA表达谱变化与治疗相关输出联系起来的功效。

关键词: β细胞功能，糖尿病，microRNA，分化，胰岛素，IPC。

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图形摘要

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