Design and Evaluation of Long Acting Biodegradable PLGA Microspheres for Ocular Drug Delivery

Title:Design and Evaluation of Long Acting Biodegradable PLGA Microspheres for Ocular Drug Delivery

Volume: 11 Issue: 1

Author(s): Anjali Pandya, Rajani Athawale*, Durga Puro and Geeta Bhagwat

Affiliation:

• Prin. K.M. Kundnani College of Pharmacy, Cuffe Parade, Mumbai 400 005, Maharashtra,India

Keywords: Dexamethasone, PLGA microspheres, long acting, intravitreal, sensory organs, receptors.

Abstract: Background: The research work involves the development of PLGA biodegradable microspheres loaded with dexamethasone for intraocular delivery.

Objective: The study aimed to design and evaluate long acting PLGA microspheres for ocular delivery of dexamethasone.

Methods: The present formulation involves the development of long-acting dexamethasone loaded microspheres composed of a biodegradable controlled release polymer, Poly(D,L-lactide-coglycolide) (PLGA), for the treatment of posterior segment eye disorders intravitreally. PLGA with a monomer ratio of 50:50 of lactic acid to glycolic acid was used to achieve a drug release for up to 45 days. Quality by Design approach was utilized for designing the experiments. Single emulsion solvent evaporation technique along with high-pressure homogenization was used to facilitate the formation of microspheres.

Results: Particle size evaluation, drug content and drug entrapment efficiency were determined for the microspheres. Particle size and morphology were observed using Field Emission Gun- Scanning Electron Microscopy (FEG-SEM) and microspheres were in the size range of 1-5 μm. Assessment of drug release was done using in vitro studies and trans retinal permeation was observed by ex vivo studies using goat retinal tissues.

Conclusion: Considering the dire need for prolonged therapeutic effect on diseases of the posterior eye, an intravitreal long-acting formulation was designed. The use of biodegradable polymer with biocompatible degradation products was a rational approach to achieve this aim. The outcome of the present research shows that developed microspheres would provide a long-acting drug profile and reduce the frequency of administration thereby improving patient compliance.

Cite this article as:

Pandya Anjali , Athawale Rajani *, Puro Durga and Bhagwat Geeta , Design and Evaluation of Long Acting Biodegradable PLGA Microspheres for Ocular Drug Delivery, Nanoscience & Nanotechnology-Asia 2021; 11 (1) . https://dx.doi.org/10.2174/2210681210666191223144755