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Review Article

急性肝损伤患者的miRNA特征：临床关注和相关性

卷 20, 期 5, 2020

页: [325 - 335] 页: 11

弟呕挨: 10.2174/1566524020666191211153546

价格: $65

摘要

非编码RNA在生命系统中的生物学意义可以被高度开发。 miRNA在细胞调节级联反应的上游位置，并保持其优异性能。关于在实验诱导的肝损伤模型中发生变化的多种miRNA的大量信息，可以找到。这些miRNA支配的潜在机制已通过基于细胞的实验推断出来，但有关肝损伤患者miRNA信号的科学知识是原始的，缺乏科学的清晰度。因此，至关重要的是深入了解患者中miRNA的状态和协同作用，这些患者在肝脏中具有不同程度的急性毒性表现。尽管一些miRNA正在临床试验中进行研究，但是关于其他miRNA在肝脏疾病中的功能作用，存在重大的研究空白。这篇评论文章是对患者基于疾病或药物/酒精为基础的急性肝损伤及其miRNA谱图改变的精心汇编。本文还讨论了基于细胞或鼠类模型中潜在的miRNA-肝脏串扰的研究报告，以得出与临床发现的相关性。

关键词: microRNA，急性肝损伤，患者，生物标志物，肝硬化，小鼠模型。

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[1]
Mokdad AA, Lopez AD, Shahraz S, et al. Liver cirrhosis mortality in 187 countries between 1980 and 2010: a systematic analysis. BMC Med 2014; 12(1): 145.
[http://dx.doi.org/10.1186/s12916-014-0145-y] [PMID: 25242656]
[2]
Asrani SK, Devarbhavi H, Eaton J, Kamath PS. Burden of liver diseases in the world. J Hepatol 2019; 70: 151-71.
[PMID: 30266282]
[3]
Uhl P, Fricker G, Haberkorn U, Mier W. Current status in the therapy of liver diseases. Int J Mol Sci 2014; 15(5): 7500-12.
[http://dx.doi.org/10.3390/ijms15057500] [PMID: 24786290]
[4]
Huang Y, Yan Y, Xv W, Qian G, Li C, Zou H, et al. A new insight into the roles of MiRNAs in metabolic syndrome. BioMed research international 2018 2018.
[http://dx.doi.org/10.1155/2018/7372636]
[5]
Vafadar A, Shabaninejad Z, Movahedpour A, et al. Long non-coding RNAs as epigenetic regulators in cancer. Curr Pharm Des 2019; 25(33): 3563-77.
[http://dx.doi.org/10.2174/1381612825666190830161528] [PMID: 31470781]
[6]
Esteller M. Non-coding RNAs in human disease. Nat Rev Genet 2011; 12(12): 861-74.
[http://dx.doi.org/10.1038/nrg3074] [PMID: 22094949]
[7]
O’Brien J, Hayder H, Zayed Y, Peng C. Overview of microRNA biogenesis, mechanisms of actions, and circulation. Front Endocrinol (Lausanne) 2018; 9: 402.
[http://dx.doi.org/10.3389/fendo.2018.00402] [PMID: 30123182]
[8]
Nishikawa T, Bellance N, Damm A, et al. A switch in the source of ATP production and a loss in capacity to perform glycolysis are hallmarks of hepatocyte failure in advance liver disease. J Hepatol 2014; 60(6): 1203-11.
[http://dx.doi.org/10.1016/j.jhep.2014.02.014] [PMID: 24583248]
[9]
Tétreault N, De Guire V. miRNAs: their discovery, biogenesis and mechanism of action. Clin Biochem 2013; 46(10-11): 842-5.
[http://dx.doi.org/10.1016/j.clinbiochem.2013.02.009] [PMID: 23454500]
[10]
Zhou X, Duan X, Qian J, Li F. Abundant conserved microRNA target sites in the 5′-untranslated region and coding sequence. Genetica 2009; 137(2): 159-64.
[http://dx.doi.org/10.1007/s10709-009-9378-7] [PMID: 19578934]
[11]
Huang Y, Shen XJ, Zou Q, Wang SP, Tang SM, Zhang GZ. Biological functions of microRNAs: a review. J Physiol Biochem 2011; 67(1): 129-39.
[http://dx.doi.org/10.1007/s13105-010-0050-6] [PMID: 20981514]
[12]
Chen Y, Verfaillie CM. MicroRNAs: the fine modulators of liver development and function. Liver Int 2014; 34(7): 976-90.
[http://dx.doi.org/10.1111/liv.12496] [PMID: 24517588]
[13]
Bala S, Marcos M, Szabo G. Emerging role of microRNAs in liver diseases. World J Gastroenterol 2009; 15(45): 5633-40.
[http://dx.doi.org/10.3748/wjg.15.5633] [PMID: 19960558]
[14]
Organization WH. Global hepatitis report 2017. World Health Organization 2017.
[15]
Bihrer V, Waidmann O, Friedrich-Rust M, et al. Serum microRNA-21 as marker for necroinflammation in hepatitis C patients with and without hepatocellular carcinoma. PLoS One 2011; 6(10) e26971
[http://dx.doi.org/10.1371/journal.pone.0026971] [PMID: 22066022]
[16]
Shrivastava S, Petrone J, Steele R, Lauer GM, Di Bisceglie AM, Ray RB. Up-regulation of circulating miR-20a is correlated with hepatitis C virus-mediated liver disease progression. Hepatology 2013; 58(3): 863-71.
[http://dx.doi.org/10.1002/hep.26296] [PMID: 23390075]
[17]
Wang JH, Jiang D, Rao HY, Zhao JM, Wang Y, Wei L. Absolute quantification of serum microRNA-122 and its correlation with liver inflammation grade and serum alanine aminotransferase in chronic hepatitis C patients. Int J Infect Dis 2015; 30: 52-6.
[http://dx.doi.org/10.1016/j.ijid.2014.09.020] [PMID: 25461662]
[18]
Morita K, Taketomi A, Shirabe K, et al. Clinical significance and potential of hepatic microRNA-122 expression in hepatitis C. Liver Int 2011; 31(4): 474-84.
[http://dx.doi.org/10.1111/j.1478-3231.2010.02433.x] [PMID: 21199296]
[19]
Dubin PH, Yuan H, Devine RK, Hynan LS, Jain MK, Lee WM. Acute Liver Failure Study Group. Micro-RNA-122 levels in acute liver failure and chronic hepatitis C. J Med Virol 2014; 86(9): 1507-14.
[http://dx.doi.org/10.1002/jmv.23987] [PMID: 24895202]
[20]
Diaz G, Melis M, Tice A, et al. Identification of microRNAs specifically expressed in hepatitis C virus-associated hepatocellular carcinoma. Int J Cancer 2013; 133(4): 816-24.
[http://dx.doi.org/10.1002/ijc.28075] [PMID: 23390000]
[21]
Varnholt H, Drebber U, Schulze F, et al. MicroRNA gene expression profile of hepatitis C virus-associated hepatocellular carcinoma. Hepatology 2008; 47(4): 1223-32.
[http://dx.doi.org/10.1002/hep.22158] [PMID: 18307259]
[22]
Zhang Y, Wei W, Cheng N, et al. Hepatitis C virus-induced up-regulation of microRNA-155 promotes hepatocarcinogenesis by activating Wnt signaling. Hepatology 2012; 56(5): 1631-40.
[http://dx.doi.org/10.1002/hep.25849] [PMID: 22610915]
[23]
Banaudha K, Kaliszewski M, Korolnek T, et al. MicroRNA silencing of tumor suppressor DLC-1 promotes efficient hepatitis C virus replication in primary human hepatocytes. Hepatology 2011; 53(1): 53-61.
[http://dx.doi.org/10.1002/hep.24016] [PMID: 20967756]
[24]
Bandiera S, Pernot S, El Saghire H, et al. Hepatitis C virus-induced upregulation of microRNA miR-146a-5p in hepatocytes promotes viral infection and deregulates metabolic pathways associated with liver disease pathogenesis. J Virol 2016; 90(14): 6387-400.
[http://dx.doi.org/10.1128/JVI.00619-16] [PMID: 27147737]
[25]
Zhou J, Yu L, Gao X, et al. Plasma microRNA panel to diagnose hepatitis B virus-related hepatocellular carcinoma. J Clin Oncol 2011; 29(36): 4781-8.
[http://dx.doi.org/10.1200/JCO.2011.38.2697] [PMID: 22105822]
[26]
Zheng Q-F, Zhang J-Y, Wu J-S, et al. Upregulation of miRNA-130a represents good prognosis in patients With HBV-related acute-on-chronic liver failure: A prospective study. Medicine (Baltimore) 2016; 95(6) e2639
[http://dx.doi.org/10.1097/MD.0000000000002639] [PMID: 26871786]
[27]
Ji F, Yang B, Peng X, Ding H, You H, Tien P. Circulating microRNAs in hepatitis B virus-infected patients. J Viral Hepat 2011; 18(7): e242-51.
[http://dx.doi.org/10.1111/j.1365-2893.2011.01443.x] [PMID: 21692939]
[28]
Zhang H, Li Q-Y, Guo Z-Z, et al. Serum levels of microRNAs can specifically predict liver injury of chronic hepatitis B. World J Gastroenterol 2012; 18(37): 5188-96.
[PMID: 23066312]
[29]
Yamaura Y, Tatsumi N, Takagi S, et al. Serum microRNA profiles in patients with chronic hepatitis B, chronic hepatitis C, primary biliary cirrhosis, autoimmune hepatitis, nonalcoholic steatohepatitis, or drug-induced liver injury. Clin Biochem 2017; 50(18): 1034-9.
[http://dx.doi.org/10.1016/j.clinbiochem.2017.08.010] [PMID: 28823616]
[30]
Tan Y, Ge G, Pan T, Wen D, Gan J. Serum MiRNA panel as potential biomarkers for chronic hepatitis B with persistently normal alanine aminotransferase. Clin Chim Acta 2015; 451(Pt B): 232-9.
[http://dx.doi.org/10.1016/j.cca.2015.10.002] [PMID: 26483130]
[31]
Ding W, Xin J, Jiang L, et al. Characterisation of peripheral blood mononuclear cell microRNA in hepatitis B-related acute-on-chronic liver failure. Sci Rep 2015; 5: 13098.
[http://dx.doi.org/10.1038/srep13098] [PMID: 26267843]
[32]
Ura S, Honda M, Yamashita T, et al. Differential microRNA expression between hepatitis B and hepatitis C leading disease progression to hepatocellular carcinoma. Hepatology 2009; 49(4): 1098-112.
[http://dx.doi.org/10.1002/hep.22749] [PMID: 19173277]
[33]
Arataki K, Hayes CN, Akamatsu S, et al. Circulating microRNA-22 correlates with microRNA-122 and represents viral replication and liver injury in patients with chronic hepatitis B. J Med Virol 2013; 85(5): 789-98.
[http://dx.doi.org/10.1002/jmv.23540] [PMID: 23508904]
[34]
Waidmann O, Bihrer V, Pleli T, et al. Serum microRNA-122 levels in different groups of patients with chronic hepatitis B virus infection. J Viral Hepat 2012; 19(2): e58-65.
[http://dx.doi.org/10.1111/j.1365-2893.2011.01536.x] [PMID: 22239527]
[35]
Wang S, Qiu L, Yan X, et al. Loss of microRNA 122 expression in patients with hepatitis B enhances hepatitis B virus replication through cyclin G(1) -modulated P53 activity. Hepatology 2012; 55(3): 730-41.
[http://dx.doi.org/10.1002/hep.24809] [PMID: 22105316]
[36]
Sarkar N, Panigrahi R, Pal A, et al. Expression of microRNA-155 correlates positively with the expression of Toll-like receptor 7 and modulates hepatitis B virus via C/EBP-β in hepatocytes. J Viral Hepat 2015; 22(10): 817-27.
[http://dx.doi.org/10.1111/jvh.12390] [PMID: 25720442]
[37]
Lan SH, Wu SY, Zuchini R, et al. Autophagy suppresses tumorigenesis of hepatitis B virus-associated hepatocellular carcinoma through degradation of microRNA-224. Hepatology 2014; 59(2): 505-17.
[http://dx.doi.org/10.1002/hep.26659] [PMID: 23913306]
[38]
Guo H, Liu H, Mitchelson K, et al. MicroRNAs-372/373 promote the expression of hepatitis B virus through the targeting of nuclear factor I/B. Hepatology 2011; 54(3): 808-19.
[http://dx.doi.org/10.1002/hep.24441] [PMID: 21608007]
[39]
Huang J, Wang Y, Guo Y, Sun S. Down-regulated microRNA-152 induces aberrant DNA methylation in hepatitis B virus-related hepatocellular carcinoma by targeting DNA methyltransferase 1. Hepatology 2010; 52(1): 60-70.
[http://dx.doi.org/10.1002/hep.23660] [PMID: 20578129]
[40]
Mirzaei HR, Sahebkar A, Mohammadi M, et al. Circulating microRNAs in hepatocellular carcinoma: potential diagnostic and prognostic biomarkers. Curr Pharm Des 2016; 22(34): 5257-69.
[http://dx.doi.org/10.2174/1381612822666160303110838] [PMID: 26935703]
[41]
Weiler-Normann C, Lohse AW. Acute autoimmune hepatitis: many open questions. J Hepatol 2014; 61(4): 727-9.
[http://dx.doi.org/10.1016/j.jhep.2014.06.030] [PMID: 24999018]
[42]
Migita K, Komori A, Kozuru H, et al. Circulating microRNA profiles in patients with type-1 autoimmune hepatitis. PLoS One 2015; 10(11) e0136908
[http://dx.doi.org/10.1371/journal.pone.0136908] [PMID: 26575387]
[43]
Blaya D, Aguilar-Bravo B, Hao F, et al. Expression of microRNA-155 in inflammatory cells modulates liver injury. Hepatology 2018; 68(2): 691-706.
[http://dx.doi.org/10.1002/hep.29833] [PMID: 29420849]
[44]
Song L, Zhang Z, Zhang J, et al. Ratio of microRNA-122/155 in isoniazid-induced acute liver injury in mice. Exp Ther Med 2016; 12(2): 889-94.
[http://dx.doi.org/10.3892/etm.2016.3375] [PMID: 27446292]
[45]
Bae JS, Kim J-H, Pasaje CFA, et al. Association study of genetic variations in microRNAs with the risk of hepatitis B-related liver diseases. Dig Liver Dis 2012; 44(10): 849-54.
[http://dx.doi.org/10.1016/j.dld.2012.04.021] [PMID: 22658643]
[46]
Cheong JY, Shin HD, Kim YJ, Cho SW. Association of polymorphism in MicroRNA 219-1 with clearance of hepatitis B virus infection. J Med Virol 2013; 85(5): 808-14.
[http://dx.doi.org/10.1002/jmv.23551] [PMID: 23508906]
[47]
Wang H, Yu B, Deng J, Jin Y, Xie L. Serum miR-122 correlates with short-term mortality in sepsis patients. Crit Care 2014; 18(6): 704.
[http://dx.doi.org/10.1186/s13054-014-0704-9] [PMID: 25672224]
[48]
Upadhyay KK, Jadeja RN, Thadani JM, et al. Carbon monoxide releasing molecule A-1 attenuates acetaminophen-mediated hepatotoxicity and improves survival of mice by induction of Nrf2 and related genes. Toxicol Appl Pharmacol 2018; 360: 99-108.
[http://dx.doi.org/10.1016/j.taap.2018.09.034] [PMID: 30273691]
[49]
Yang X, Salminen WF, Shi Q, et al. Potential of extracellular microRNAs as biomarkers of acetaminophen toxicity in children. Toxicol Appl Pharmacol 2015; 284(2): 180-7.
[http://dx.doi.org/10.1016/j.taap.2015.02.013] [PMID: 25708609]
[50]
Yu D, Wu L, Gill P, et al. Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans. Arch Toxicol 2018; 92(2): 845-58.
[http://dx.doi.org/10.1007/s00204-017-2090-y] [PMID: 29067470]
[51]
Gill P, Bhattacharyya S, McCullough S, et al. MicroRNA regulation of CYP 1A2, CYP3A4 and CYP2E1 expression in acetaminophen toxicity. Sci Rep 2017; 7(1): 12331.
[http://dx.doi.org/10.1038/s41598-017-11811-y] [PMID: 28951593]
[52]
Vliegenthart AD, Shaffer JM, Clarke JI, et al. Comprehensive microRNA profiling in acetaminophen toxicity identifies novel circulating biomarkers for human liver and kidney injury. Sci Rep 2015; 5: 15501.
[http://dx.doi.org/10.1038/srep15501] [PMID: 26489516]
[53]
Vliegenthart ADB, Berends C, Potter CMJ, Kersaudy-Kerhoas M, Dear JW. MicroRNA-122 can be measured in capillary blood which facilitates point-of-care testing for drug-induced liver injury. Br J Clin Pharmacol 2017; 83(9): 2027-33.
[http://dx.doi.org/10.1111/bcp.13282] [PMID: 28257154]
[54]
Ward J, Kanchagar C, Veksler-Lublinsky I, et al. Circulating microRNA profiles in human patients with acetaminophen hepatotoxicity or ischemic hepatitis. Proc Natl Acad Sci USA 2014; 111(33): 12169-74.
[http://dx.doi.org/10.1073/pnas.1412608111] [PMID: 25092309]
[55]
Starkey Lewis PJ, Dear J, Platt V, et al. Circulating microRNAs as potential markers of human drug-induced liver injury. Hepatology 2011; 54(5): 1767-76.
[http://dx.doi.org/10.1002/hep.24538] [PMID: 22045675]
[56]
Thulin P, Nordahl G, Gry M, et al. Keratin-18 and microRNA-122 complement alanine aminotransferase as novel safety biomarkers for drug-induced liver injury in two human cohorts. Liver Int 2014; 34(3): 367-78.
[http://dx.doi.org/10.1111/liv.12322] [PMID: 24118944]
[57]
Scholten D, Trebicka J, Liedtke C, Weiskirchen R. The carbon tetrachloride model in mice. Laboratory animals 2015; 491_suppl:: 4-11.
[http://dx.doi.org/10.1177/0023677215571192]
[58]
Roderburg C, Urban GW, Bettermann K, et al. Micro-RNA profiling reveals a role for miR-29 in human and murine liver fibrosis. Hepatology 2011; 53(1): 209-18.
[http://dx.doi.org/10.1002/hep.23922] [PMID: 20890893]
[59]
Russo MW, Steuerwald N, Norton HJ, et al. Profiles of miRNAs in serum in severe acute drug induced liver injury and their prognostic significance. Liver Int 2017; 37(5): 757-64.
[http://dx.doi.org/10.1111/liv.13312] [PMID: 27860186]
[60]
López-Riera M, Conde I, Tolosa L, et al. New microRNA biomarkers for drug-induced steatosis and their potential to predict the contribution of drugs to non-alcoholic fatty liver disease. Front Pharmacol 2017; 8: 3.
[http://dx.doi.org/10.3389/fphar.2017.00003] [PMID: 28179883]
[61]
Blaya D, Coll M, Rodrigo-Torres D, et al. Integrative microRNA profiling in alcoholic hepatitis reveals a role for microRNA-182 in liver injury and inflammation. Gut 2016; 65(9): 1535-45.
[http://dx.doi.org/10.1136/gutjnl-2015-311314] [PMID: 27196584]
[62]
Satishchandran A, Ambade A, Rao S, et al. MicroRNA 122, regulated by GRLH2, protects livers of mice and patients from ethanol-induced liver disease. Gastroenterology 2018; 154(1): 238-52. e7
[63]
Li M, He Y, Zhou Z, et al. MicroRNA-223 ameliorates alcoholic liver injury by inhibiting the IL-6-p47phox-oxidative stress pathway in neutrophils. Gut 2017; 66(4): 705-15.
[http://dx.doi.org/10.1136/gutjnl-2016-311861] [PMID: 27679493]
[64]
Wan Y, McDaniel K, Wu N, et al. Regulation of cellular senescence by miR-34a in alcoholic liver injury. Am J Pathol 2017; 187(12): 2788-98.
[http://dx.doi.org/10.1016/j.ajpath.2017.08.027] [PMID: 29128099]
[65]
Tang Y, Banan A, Forsyth CB, et al. Effect of alcohol on miR-212 expression in intestinal epithelial cells and its potential role in alcoholic liver disease. Alcohol Clin Exp Res 2008; 32(2): 355-64.
[http://dx.doi.org/10.1111/j.1530-0277.2007.00584.x] [PMID: 18162065]
[66]
McDaniel K, Huang L, Sato K, et al. The let-7/Lin28 axis regulates activation of hepatic stellate cells in alcoholic liver injury. J Biol Chem 2017; 292(27): 11336-47.
[http://dx.doi.org/10.1074/jbc.M116.773291] [PMID: 28536261]
[67]
Eguchi A, Lazaro RG, Wang J, et al. Extracellular vesicles released by hepatocytes from gastric infusion model of alcoholic liver disease contain a MicroRNA barcode that can be detected in blood. Hepatology 2017; 65(2): 475-90.
[http://dx.doi.org/10.1002/hep.28838] [PMID: 27639178]

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