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Research Article

华南地区RXRG单核苷酸多态性与2型糖尿病遗传易感性的关系

卷 20, 期 6, 2020

页: [408 - 414] 页: 7

弟呕挨: 10.2174/1566524020666191206163951

价格: $65

摘要

目的：探讨中国南方汉族人群RXRG rs1467664，rs3753898基因多态性与2型糖尿病遗传易感性的关系。 方法：在我们的病例对照研究中，使用SNPscanTM试剂盒对1092例T2D患者和1092例正常人作为单核苷酸多态性（SNP）rs1467664和rs3753898进行基因分型。用SPSS 20.0软件分析两组的基因型和等位基因频率分布。 结果：RXRG rs3753898的基因型和等位基因的分布在两组之间具有统计学意义，但rs1467664的基因型和等位基因的分布没有显着差异。两组在年龄，性别和体重指数调整前后，rs3753898在加性，显性和隐性模型下均具有统计学意义（P <0.05），但在显性和共显性遗传模型下均未发现统计学差异（P <0.05）。 P> 0.05）。 rs1467664的遗传模型在两组之间没有显着差异（P> 0.05）。由rs1467664等位基因T和rs3753898等位基因A组成的单倍型是T2D的高风险因素，OR = 1.27，95％CI（1.09-1.47），Padj = 0.002。 结论：我们的结果表明，RXRG rs3753898的单核苷酸多态性可能与2型糖尿病的遗传易感性有关。由rs1467664的等位基因T和rs3753898的等位基因A组成的单倍型是2型糖尿病的危险因素，这表明RXRG基因的遗传变异可能是中国汉族人群糖尿病的遗传原因。

关键词: 2型糖尿病（T2D），单核苷酸多态性（SNP），类维生素X受体伽马（RXRG），中国汉族人群。

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