Abstract
Artemisinin, a sesquiterpene lactone endoperoxide, and a number of its precursors, metabolites and semisynthetic derivatives have shown to possess antimalarial properties. Several methods have been reported for the measurement of artemisinin and its main derivatives in plant material and biological fluids. However, most of them are either not sufficiently sensitive and do not offer reliable results, or are difficult to apply in routine analyses. Therefore, new m ethods for the determination of these compounds, such as supercritical fluid extraction and chromatography, pressurized solvent extraction, microwave-assisted extraction, high-performance liquid chromatography coupled to mass spectrometry or evaporative light scattering detection, will be presented. Applications to plant material, pharmaceutical formulations and biological fluids will also be reviewed.
Keywords: Artemisinin, Artemisia annua, A. annua, artemisitene, artemisinic acid, arteannuin B, Pressurized solvent extraction (PSE), Microwave-assisted Extraction, Thermolysis, dihydroartemisinin, TANDEM MASS SPECTROMETRY, HPLC-UV, HPLC-MS, ENZYME-LINKED IMMUNOSORBENT ASSAY, CAPILLARY ELECTROPHORESIS, EVAPORATIVE LIGHT SCATTERING DETECTOR
Current Medicinal Chemistry
Title: New Trends in Extraction, Identification and Quantification of Artemisinin and its Derivatives
Volume: 8 Issue: 15
Author(s): P. Christen and J. L. Veuthey
Affiliation:
Keywords: Artemisinin, Artemisia annua, A. annua, artemisitene, artemisinic acid, arteannuin B, Pressurized solvent extraction (PSE), Microwave-assisted Extraction, Thermolysis, dihydroartemisinin, TANDEM MASS SPECTROMETRY, HPLC-UV, HPLC-MS, ENZYME-LINKED IMMUNOSORBENT ASSAY, CAPILLARY ELECTROPHORESIS, EVAPORATIVE LIGHT SCATTERING DETECTOR
Abstract: Artemisinin, a sesquiterpene lactone endoperoxide, and a number of its precursors, metabolites and semisynthetic derivatives have shown to possess antimalarial properties. Several methods have been reported for the measurement of artemisinin and its main derivatives in plant material and biological fluids. However, most of them are either not sufficiently sensitive and do not offer reliable results, or are difficult to apply in routine analyses. Therefore, new m ethods for the determination of these compounds, such as supercritical fluid extraction and chromatography, pressurized solvent extraction, microwave-assisted extraction, high-performance liquid chromatography coupled to mass spectrometry or evaporative light scattering detection, will be presented. Applications to plant material, pharmaceutical formulations and biological fluids will also be reviewed.
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Cite this article as:
Christen P. and Veuthey L. J., New Trends in Extraction, Identification and Quantification of Artemisinin and its Derivatives, Current Medicinal Chemistry 2001; 8 (15) . https://dx.doi.org/10.2174/0929867013371563
DOI https://dx.doi.org/10.2174/0929867013371563 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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