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当代阿耳茨海默病研究

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ISSN (Print): 1567-2050
ISSN (Online): 1875-5828

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Research Article

Ampelopsin可改善阿尔茨海默氏病的认知障碍以及海马中炎性细胞因子和氧化应激的影响

卷 17, 期 1, 2020

页: [44 - 51] 页: 8

弟呕挨: 10.2174/1567205016666191203153447

价格: $65

摘要

背景：神经炎症和氧化应激对阿尔茨海默氏病（AD）病理生理发展中的认知缺陷有重要影响。在本研究中，我们研究了Ampelopsin（AMP）对促炎细胞因子（PIC，IL-1β，IL-6和TNF-α）以及氧化应激产物8-isoprostaglandinF2α（8-isoPGF2α的产物）的影响氧化应激）;使用AD的大鼠模型，在海马中添加8-羟基-2''-脱氧鸟苷（8-OHdG，蛋白质氧化的关键生物标记）。 方法：采用ELISA法检测PICs和氧化应激产物。免疫印迹法检测NADPH氧化酶（NOX）。空间工作记忆测试和莫里斯水迷宫被用来评估认知功能。 结果：我们观察到了AD大鼠海马中IL-1β，IL-6和TNF-α以及8-isoPGF2α和8-OHdG的扩增。 AMP减弱了PIC的上调和氧化应激的产生。 AMP还抑制AD大鼠海马中的NOX4。值得注意的是，AMP可以大大改善AD大鼠的学习能力，这与PIC的信号通路和氧化应激有关。 结论：AMP通过抑制神经炎症和氧化应激的信号通路，在改善AD大鼠记忆障碍中起着重要作用，表明AMP作为替代性替代干预措施，有望预防和缓解AD认知功能障碍的发展。

关键词: 神经炎症，氧化应激，海马，阿尔茨海默氏病，ampelspsin，神经退行性疾病。

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