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Clinical Trial

新鲜石榴汁对2型糖尿病患者血清皮质醇和甲状腺素的短期影响

卷 20, 期 5, 2020

页: [355 - 360] 页: 6

弟呕挨: 10.2174/1566524019666191129104153

价格: $65

摘要

背景：已经在各种场合确定了石榴汁对2型糖尿病的影响。但是，尚未发现对作为能量代谢的主要控制者的皮质醇和甲状腺素激素的这种作用。 目的：在这项研究中，我们打算测量新鲜石榴汁对2型糖尿病患者血清皮质醇和甲状腺素的短期影响。 材料和方法：这项研究是一项随机临床试验，其中以1.5毫升kg-1的剂量对89名禁食的2型糖尿病患者补充新鲜的石榴汁。然后在汁液施用之前和之后1和3小时收集血液样本。使用市售的化学发光免疫分析试剂盒评估血清皮质醇和甲状腺素。 结果：摄入新鲜的石榴汁后，2型糖尿病患者的血清皮质醇（而非甲状腺素）显着降低（P <0.0001）。此外，在新招募的患者中，皮质醇对新鲜石榴汁的反应与空腹血糖水平之间无显着相关性（r2 = 0.00003，P = 0.9569）。此外，在征募的男性和女性之间，对新鲜石榴汁的皮质醇反应无显着差异（P = 0.9118）。 结论：总的来说，新鲜石榴汁在2型糖尿病患者中，在摄入果汁1小时后降低血清皮质醇，但未在摄入果汁3小时后降低血清甲状腺素。另外，发现皮质醇对新鲜石榴汁的反应不受患者性别和空腹血糖水平的影响。

关键词: 石榴汁，皮质醇，甲状腺素，2型糖尿病，临床试验，甲状腺素。

« Previous Next »
[1]
Razani Z, Dastani M, Kazerani HR. Cardioprotective effects of pomegranate (Punica granatum) juice in patients with ischemic heart disease. Phytother Res 2017; 31(11): 1731-8.
[http://dx.doi.org/10.1002/ptr.5901] [PMID: 28913846]
[2]
Banihani SA, Makahleh SM, El-Akawi Z, et al. Fresh pomegranate juice ameliorates insulin resistance, enhances β-cell function, and decreases fasting serum glucose in type 2 diabetic patients. Nutr Res 2014; 34(10): 862-7.
[http://dx.doi.org/10.1016/j.nutres.2014.08.003] [PMID: 25223711]
[3]
Banihani SA, Shuaibu SM, Al-Husein BA, Makahleh SS. Fresh pomegranate juice decreases fasting serum erythropoietin in patients with type 2 diabetes. Int J Food Sci 2019; 2019 1269341
[http://dx.doi.org/10.1155/2019/1269341] [PMID: 31139640]
[4]
Husari A, Hashem Y, Zaatari G, El Sabban M. Pomegranate juice prevents the formation of lung nodules secondary to chronic cigarette smoke exposure in an animal model. Oxid Med Cell Longev 2017; 2017 6063201
[http://dx.doi.org/10.1155/2017/6063201] [PMID: 29333211]
[5]
Sharma P, McClees SF, Afaq F. Pomegranate for prevention and treatment of cancer: an update. Molecules 2017; 22(1): 22.
[http://dx.doi.org/10.3390/molecules22010177] [PMID: 28125044]
[6]
Türk G, Sönmez M, Aydin M, et al. Effects of pomegranate juice consumption on sperm quality, spermatogenic cell density, antioxidant activity and testosterone level in male rats. Clin Nutr 2008; 27(2): 289-96.
[http://dx.doi.org/10.1016/j.clnu.2007.12.006] [PMID: 18222572]
[7]
Ahmed AH, Subaiea GM, Eid A, Li L, Seeram NP, Zawia NH. Pomegranate extract modulates processing of amyloid-β precursor protein in an aged Alzheimer’s disease animal model. Curr Alzheimer Res 2014; 11(9): 834-43.
[PMID: 25274111]
[8]
Plat L, Byrne MM, Sturis J, et al. Effects of morning cortisol elevation on insulin secretion and glucose regulation in humans. Am J Physiol 1996; 270(1 Pt 1): E36-42.
[PMID: 8772471]
[9]
Vazquez-Anaya G, Martinez B, Soñanez-Organis JG, Nakano D, Nishiyama A, Ortiz RM. Exogenous thyroxine improves glucose intolerance in insulin-resistant rats. J Endocrinol 2017; 232(3): 501-11.
[http://dx.doi.org/10.1530/JOE-16-0428] [PMID: 27980001]
[10]
Arafah BM. Glucocorticoids with or without fludrocortisone in septic shock. N Engl J Med 2018; 379(9): 894-5.
[PMID: 30179386]
[11]
Campos-Rodríguez R, Godínez-Victoria M, Abarca-Rojano E, et al. Stress modulates intestinal secretory immunoglobulin A. Front Integr Nuerosci 2013; 7: 86.
[http://dx.doi.org/10.3389/fnint.2013.00086] [PMID: 24348350]
[12]
Walker EA, Ahmed A, Lavery GG, et al. 11beta-hydroxysteroid dehydrogenase type 1 regulation by intracellular glucose 6-phosphate provides evidence for a novel link between glucose metabolism and hypothalamo-pituitary-adrenal axis function. J Biol Chem 2007; 282(37): 27030-6.
[http://dx.doi.org/10.1074/jbc.M704144200] [PMID: 17588937]
[13]
Cho K, Chung JY, Cho SK, et al. Antihyperglycemic mechanism of metformin occurs via the AMPK/LXRα/POMC pathway. Sci Rep 2015; 5: 8145.
[http://dx.doi.org/10.1038/srep08145] [PMID: 25634597]
[14]
Sephton SE, Dhabhar FS, Keuroghlian AS, et al. Depression, cortisol, and suppressed cell-mediated immunity in metastatic breast cancer. Brain Behav Immun 2009; 23(8): 1148-55.
[http://dx.doi.org/10.1016/j.bbi.2009.07.007] [PMID: 19643176]
[15]
Tamijani SM, Karimi B, Amini E, et al. Thyroid hormones: Possible roles in epilepsy pathology. Seizure 2015; 31: 155-64.
[http://dx.doi.org/10.1016/j.seizure.2015.07.021] [PMID: 26362394]
[16]
Antonica F, Kasprzyk DF, Opitz R, et al. Generation of functional thyroid from embryonic stem cells. Nature 2012; 491(7422): 66-71.
[http://dx.doi.org/10.1038/nature11525] [PMID: 23051751]
[17]
Nebioglu S, Wathanaronchai P, Nebioglu D, Pruden EL, Gibson DM. Mechanisms underlying enhanced glycogenolysis in livers of 3,5,3′-triiodothyronine-treated rats. Am J Physiol 1990; 258(1 Pt 1): E109-16.
[PMID: 2105655]
[18]
Cefalu WT, Buse JB, Tuomilehto J, et al. Update and next steps for real-world translation of interventions for type 2 diabetes prevention: reflections from a diabetes care editors’ expert forum. Diabetes Care 2016; 39(7): 1186-201.
[http://dx.doi.org/10.2337/dc16-0873] [PMID: 27631469]
[19]
Fuqua JS, Rogol AD. Neuroendocrine alterations in the exercising human: implications for energy homeostasis. Metabolism 2013; 62(7): 911-21.
[http://dx.doi.org/10.1016/j.metabol.2013.01.016] [PMID: 23415825]
[20]
Whitworth JA, Brown MA, Kelly JJ, Williamson PM. Mechanisms of cortisol-induced hypertension in humans. Steroids 1995; 60(1): 76-80.
[http://dx.doi.org/10.1016/0039-128X(94)00033-9] [PMID: 7792821]
[21]
Kelly JJ, Mangos G, Williamson PM, Whitworth JA. Cortisol and hypertension. Clin Exp Pharmacol Physiol Suppl 1998; 25: S51-6.
[http://dx.doi.org/10.1111/j.1440-1681.1998.tb02301.x] [PMID: 9809193]
[22]
Asgary S, Keshvari M, Sahebkar A, Sarrafzadegan N. Pomegranate consumption and blood pressure: a review. Curr Pharm Des 2017; 23(7): 1042-50.
[http://dx.doi.org/10.2174/1381612822666161010103339] [PMID: 27748197]
[23]
Mohan M, Waghulde H, Kasture S. Effect of pomegranate juice on Angiotensin II-induced hypertension in diabetic Wistar rats. Phytother Res 2010; 24(Suppl. 2): S196-203.
[http://dx.doi.org/10.1002/ptr.3090] [PMID: 20020514]
[24]
Aviram M, Dornfeld L. Pomegranate juice consumption inhibits serum angiotensin converting enzyme activity and reduces systolic blood pressure. Atherosclerosis 2001; 158(1): 195-8.
[http://dx.doi.org/10.1016/S0021-9150(01)00412-9] [PMID: 11500191]
[25]
Stockton A, Farhat G, McDougall GJ, Al-Dujaili EAS. Effect of pomegranate extract on blood pressure and anthropometry in adults: a double-blind placebo-controlled randomised clinical trial. J Nutr Sci 2017; 6 e39
[http://dx.doi.org/10.1017/jns.2017.36] [PMID: 29152243]
[26]
Tsang C, Smail NF, Almoosawi S, Davidson I, Al-Dujaili EA. Intake of polyphenol-rich pomegranate pure juice influences urinary glucocorticoids, blood pressure and homeostasis model assessment of insulin resistance in human volunteers. J Nutr Sci 2012. 1e9
[http://dx.doi.org/10.1017/jns.2012.10] [PMID: 25191556]
[27]
Basu A, Penugonda K. Pomegranate juice: a heart-healthy fruit juice. Nutr Rev 2009; 67(1): 49-56.
[http://dx.doi.org/10.1111/j.1753-4887.2008.00133.x] [PMID: 19146506]
[28]
Banihani S, Swedan S, Alguraan Z. Pomegranate and type 2 diabetes. Nutr Res 2013; 33(5): 341-8.
[http://dx.doi.org/10.1016/j.nutres.2013.03.003] [PMID: 23684435]
[29]
Das AK, Mandal SC, Banerjee SK, Sinha S, Saha BP, Pal M. Studies on the hypoglycaemic activity of Punica granatum seed in streptozotocin induced diabetic rats. Phytother Res 2001; 15(7): 628-9.
[http://dx.doi.org/10.1002/ptr.740] [PMID: 11746848]
[30]
Ruderman NB, Carling D, Prentki M, Cacicedo JM. AMPK, insulin resistance, and the metabolic syndrome. J Clin Invest 2013; 123(7): 2764-72.
[http://dx.doi.org/10.1172/JCI67227] [PMID: 23863634]
[31]
Kola B, Christ-Crain M, Lolli F, et al. Changes in adenosine 5′-monophosphate-activated protein kinase as a mechanism of visceral obesity in Cushing’s syndrome. J Clin Endocrinol Metab 2008; 93(12): 4969-73.
[http://dx.doi.org/10.1210/jc.2008-1297] [PMID: 18782871]
[32]
Viscarra JA, Champagne CD, Crocker DE, Ortiz RM. 5'AMP-activated protein kinase activity is increased in adipose tissue of northern elephant seal pups during prolonged fasting-induced insulin resistance. J Endocrinol 2011; 209(3): 317-25.
[http://dx.doi.org/10.1530/JOE-11-0017] [PMID: 21429964]
[33]
Ding M, Wang Y, Sun D, et al. Punicalagin pretreatment attenuates myocardial ischemia-reperfusion injury via activation of AMPK. Am J Chin Med 2017; 45(1): 53-66.
[http://dx.doi.org/10.1142/S0192415X17500057] [PMID: 28081629]

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