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Review Article

阿尔茨海默氏病：与一氧化氮合酶的关联

卷 20, 期 7, 2020

页: [505 - 515] 页: 11

弟呕挨: 10.2174/1566524019666191129103117

价格: $65

摘要

一氧化氮（NO）是一种具有多效作用的气体传输剂，对生物学和医学产生了巨大影响。 NO在大脑中表现出多维的神经调节作用，特别涉及神经退行性疾病，例如阿尔茨海默氏病（AD）和认知功能障碍。已经发现NO / cGMP信号传导途径在学习和记忆中具有重要作用。最初，人们认为NO通过谷氨酸能兴奋性毒性间接在AD中发挥神经毒性作用。但是，考虑到学习记忆过程中涉及的认知功能的早期发展（包括长期增强和突触可塑性），NO具有至关重要的作用。越来越多的证据揭示了上述事实，即NOS的同种型即内皮型NO合酶（eNOS），神经元NO合酶（nNOS）和诱导型NO合酶（iNOS）在AD中具有可变表达，主要负责学习和记忆活动。在这篇综述中，我们集中于NOS亚型在AD中与NO平行的作用。此外，该综述提供了越来越多的证据，证明NO可以通过调节相关的NOS表达在AD中提供治疗途径。

关键词: 阿尔茨海默氏病，一氧化氮，cGMP，兴奋性毒性，NOS，气体递质。

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