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Current Topics in Medicinal Chemistry

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ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

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Research Article

Antioxidant and Antibacterial Activity of Sulfonamides Derived from Carvacrol: A Structure-Activity Relationship Study

Author(s): Aldo S. de Oliveira*, Luiz F. S. de Souza, Ricardo J. Nunes, Susana Johann, David L. Palomino-Salcedo, Leonardo L.G. Ferreira and Adriano D. Andricopulo

Volume 20, Issue 3, 2020

Page: [173 - 181] Pages: 9

DOI: 10.2174/1568026619666191127144336

Price: $65

Abstract

Background: Bacterial resistance to antibiotics is a growing problem in all countries and has been discussed worldwide. In this sense, the development of new drugs with antibiotic properties is highly desirable in the context of medicinal chemistry.

Methodology: In this paper we investigate the antioxidant and antibacterial potential of sulfonamides derived from carvacrol, a small molecule with drug-like properties. Most sulfonamides had antioxidant and antibacterial potential, especially compound S-6, derived from beta-naphthylamine.

Results: To understand the possible mechanisms of action involved in biological activity, the experimental results were compared with molecular docking data.

Conclusion: This research allows appropriate discussion on the identified structure activity relationships.

Keywords: Carvacrol, Sulfonamides, Bacterial resistance, S. aureus, E. coli, Antioxidant.

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