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Review Article

阿尔茨海默氏病靶向纳米药物递送系统

卷 21, 期 7, 2020

页: [628 - 646] 页: 19

弟呕挨: 10.2174/1389450120666191118123151

价格: $65

摘要

阿尔茨海默氏病（AD）是最常见的神经退行性疾病，并且是庞大且不断增长的医疗保健负担的一部分，该负担正在破坏全球超过5000万个人的认知功能。如今，治疗选择仅限于具有轻度症状获益的方法。开发有效药物的失败归因于但不限于具有多种潜在假说和多因素病理学的AD高度异质性。另外，用于诊断和治疗诸如AD的神经系统疾病的靶向药物递送至中枢神经系统（CNS）受到CNS周围血脑界面构成的挑战的限制，从而限制了治疗剂的生物利用度。在过去十年中进行的研究集中在开发新的策略以克服这些限制并成功地将药物输送到中枢神经系统。能够封装具有持续药物释放曲线和可调节理化特性的药物的纳米颗粒可以越过CNS周围的保护层。因此，纳米技术为AD治疗提供了新的希望，可以替代常规的药物递送机制。在这篇综述中，讨论了基于纳米颗粒的方法在阿尔茨海默氏病中的潜在应用及其在治疗中的意义。

关键词: 阿尔茨海默氏病，纳米颗粒，纳米技术，药物输送，靶向输送，理化。

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