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Review Article

CD28：免疫疾病的新药物靶标

卷 21, 期 6, 2020

页: [589 - 598] 页: 10

弟呕挨: 10.2174/1389450120666191114102830

价格: $65

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摘要

背景：CD28是一种细胞表面糖蛋白受体，主要在活化的T细胞上表达，属于Ig超家族，提供重要的共刺激信号。 CTLA-4与CD28具有序列同源性，并在激活后在T细胞上表达。它提供与CD28协同调节T细胞活化的抑制信号。它们两者均调节T细胞增殖和分化，并且在体内免疫应答途径中起重要作用。 目的：我们研究了CD28不同结构位点在产生共刺激信号中的特殊作用。 方法：我们回顾了相关文献，主要涉及CD28的结构以阐明其生物学功能及其在免疫应答中的作用。 结果：近年来，人们越来越重视CD28，CD28被认为是许多现代疾病（尤其是某些免疫性疾病）的主要治疗靶标。 结论：本文主要介绍CD28的结构及其相关的生物学功能，以及靶向CD28的共刺激途径在疾病治疗中的应用。

关键词: CD28，CTLA-4，T细胞活化，配体，免疫应答，共刺激，人类疾病。

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