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Current Topics in Medicinal Chemistry

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ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

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Perspectives in Medicinal Chemistry

Perspectives on Anti-Candida Drug Development

Author(s): Ashok K. Dubey* and Rajeev K. Singla

Volume 19, Issue 26, 2019

Page: [2375 - 2376] Pages: 2

DOI: 10.2174/156802661926191114102349

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Ramos-Martínez, A.; Vicente-López, N.; Sánchez-Romero, I.; Padilla, B.; Merino-Amador, P.; Garnacho-Montero, J. Ruiz-Camps, I.; Montejo, M. Salavert, M.; Mensa, J.; Cuenca-Estrella, M.; Members of the CANDIPOP Project from GEIH-GEMICOMED (SEIMC) and REIPI. Epidemiology and prognosis of candidaemia in elderly patients. Mycoses, 2017, 60, 808-817.
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Kullberg, B.J.; Arendrup, M.C. Invasive candidiasis. N. Engl. J. Med., 2015, 373, 1445-1456.
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Tsui, C.; Kong, E.C.; Jabra-Rizk, M.A. Pathogenesis of Candida albicans biofilm. Pathog. Dis., 2016, 74ftw018
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Srivastava, V.; Singla, R.K.; Dubey, A.K. Emerging virulence, drug resistance and future anti-fungal drugs for Candida pathogens. Curr. Top. Med. Chem., 2018, 18, 759-778.
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Satoh, K.; Makimura, K.; Hasumi, Y.; Nishiyama, Y.; Uchida, K.; Yamaguchi, H. Candida auris sp. nov., a novel ascomycetous yeast isolated from the external ear canal of an inpatient in a Japanese hospital. Microbiol. Immunol., 2009, 53, 41-44.
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Hofs, S.; Magavero, S.; Hube, B. Interaction of Candida albicans with host cells: virulence factors, host defense, escape strategies, and the microbiota. J. Microbiol., 2016, 54, 149-169.
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Baixench, M.; Aoun, N.; Desnos-Ollivier, M.; Garcia-Hermoso, D.; Bretagne, S.; Ramires, S.; Piketty, C.; Dannaoui, E. Acquired resistance to echinocandins in Candida albicans: case report and review. J. Antimicrob. Chemother., 2007, 59, 1076-1083.
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Alexander, B.D.; Johnson, M.D.; Pfeiffer, C.D.; Jiménez-Ortigosa, C.; Catania, J.; Booker, R.; Castanheira, M.; Messer, S.A.; Perlin, D.S.; Pfaller, M.A. Increasing echinocandin resistance in Candida glabrata: clinical failure correlates with presence of FKS mutations and elevated minimum inhibitory concentrations. Clin. Infect. Dis., 2013, 56, 1724-1732.
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Ellis, D. Amphotericin B: spectrum and resistance. J. Antimicrob. Chemother., 2002, 49(S1), 7-10.
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Mesa-Arango, A.C.; Rueda, C.; Román, E.; Quintin, J.; Terrón, M.C.; Luque, D.; Netea, M.G.; Pla, J.; Zaragoza, O. Cell wall changes in amphotericin B-resistant strains from Candida tropicalis and relationship with the immune responses elicited by the host. Antimicrob. Agents Chemother., 2016, 60(4), 2326-2335.
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Mayer, F.L.; Wilson, D.; Hube, B. Candida albicans pathogenicity mechanisms. Virulence, 2013, 4(2), 119-128.
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Wong, S.S.W.; Samaranayake, L.P.; Seneveviratne, C.J. In pursuit of ideal anti-fungal agents for Candida infection: high-throughput screening of small molecules. Drug Discov. Today, 2014, 19(11), 1721-1730.
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Siles, S.A.; Srinivasan, A.; Pierce, C.G.; Lopez-Ribot, J.L.; Ramasubramanian, A.K. High-throughput screening of a collection of known pharmacologically active small compounds for identification of Candida albicans biofilm inhibitors. Antimicrob. Agents Chemother., 2013, 57(8), 3681-3687.
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Moraes, D.C.; Ferreira-Pereira, A. Insights on the anticandidal activity of non-antifungal drugs. J. Mycol. Med., 2019, 29(3), 253-259.
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Kim, J.H.; Chan, K.L.; Cheng, L.W.; Tell, L.A.; Byrne, B.A.; Clothier, K.; Land, K.M. High efficiency drug repurposing design for new antifungal agents. Methods Protoc., 2019, 2E31

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