摘要
结直肠癌(Colorectal cancer, CRC)是全球最常见的癌症之一。在发达国家，该病的死亡率仍然很高，但由于有效的筛查方案，该病已形成流行;然而，由于生活方式的西方化，许多其他国家的发病率有所上升。虽然CRC的治疗在过去几年有所改善，但这些方法的副作用不容忽视。最近，游离脂肪酸受体家族的成员已成为许多疾病的诱人的药理靶点，包括哮喘;研究还指出了它们在癌变中的作用。在这里，我们讨论了目前的知识和未来的发展方向在FFAR的相关CRC研究。FFAR调节的矛盾结果可能与FFAR配体的多效性、受体分布和信号转导的不同有关。因此，我们指出了进一步研究的方向，以充分利用FFARs在CRC中的潜力。
关键词: 游离脂肪酸受体，结直肠癌，脂肪酸，G蛋白偶联受体，癌症，饮食
图形摘要
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