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Medicinal Chemistry

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General Review Article

NMR: From Molecular Mechanism to its Application in Medical Care

Author(s): Zhenhong Zhang, Xiaohong Meng, Wei Cui, Syed S. Ahmad, Mohammad A. Kamal and Jinguo Zhang*

Volume 16, Issue 8, 2020

Page: [1089 - 1098] Pages: 10

DOI: 10.2174/1573406415666191111141630

Price: $65

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Abstract

Background: Nuclear Magnetic Resonance (NMR) spectroscopy is a systematic science strategy utilized in pharmaceutical research, development, quality control, and research to decide the content and purity of a sample as well as its sub-atomic structure. There are several parameters working for better execution of NMR which can include chemical shifts, spin multiplicity, pH dependence, heteronuclear and homonuclear covalent network, and the atomic overhauser impact. NMR imaging offers an extensive scope of potential outcomes for the portrayal of skeletal muscle structure, function and metabolism. 1H additionally has the most noteworthy NMR affectability of any nucleus. The principle of NMR depends on the spins of atomic nuclei. The magnetic estimations rely on an unpaired electron, while NMR estimates attractive impact brought about by the turn of protons and neutrons. The nucleons have intrinsic angular momenta or spins, which is considered as basic magnet.

Conclusion: The presence of atomic attraction was uncovered in the hyperfine structure of spectral lines. If the nucleus magnetic moment is put in the magnetic field, the phenomenon of space quantization can be observed and each allowed direction will have a marginally unique energy level. Invitro, high-resolution NMR spectroscopy helps to assess tumor metabolism by the investigation of body liquids like urine, blood and removed tissue specimens. In-cell NMR is a powerful technique to assess strong compounds in medication improvement to spare exploratory expenses.

Keywords: NMR, chemical-shift, MRI, MRS, magnetic field, electrons.

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