Abstract
Background: Aspergillus Versicolor is a marine-derived fungus isolated from Hyrtios Erectus Red Sea sponge.
Methods: The aim of this study was to carry out a pharmacological screening and investigation for the in vitro biological activity (antioxidant, cholinergic, antidiabetic and anticancer) of Aspergillus Versicolor crude extract’s active compounds by using different qualitative and quantitative methods.
Results: The present study results showed that Aspergillus Versicolor crude extracts contain 0.6 mg total phenolic/mg crude extract. Aspergillus Versicolor also showed a potent antioxidative capacity by decreasing the oxidation of ABTS. The anticancer and inhibitory effects of Aspergillus Versicolor crude extracts on PTK and SHKI were found to be 75.29 % and 80.76%; respectively. The AChE inhibitory assay revealed that Aspergillus Versicolor extracts had an inhibitory percentage of 86.67%. Furthermore, the anti-inflammatory activity using COX1, COX2, TNF, and IL6 was 77.32, 85.21 %, 59.83%, and 56.15%; respectively. Additionally, the anti-viral effect using reverse transcriptase enzyme showed high antiviral activity with 92.10 %.
Conclusion: The current study confirmed that the Aspergillus versicolor crude extract and its active constituents showed strong effects on diminishing the oxidative stress, neurodegenerative damage, antiinflammatory, anti-cancer and anti-viral, suggesting their beneficial role as a promising fermented product in the treatment of cancer, oxidative stress, Alzheimer's, anti-inflammatory and anti-viral diseases.
Keywords: Hyrtios erectus red sea sponge, Aspergillus versicolor extracts, anti-oxidant, anti-cancer, anti-inflammatory, antiviral activities.
Graphical Abstract
[http://dx.doi.org/10.1039/C4NP00144C]
[http://dx.doi.org/10.4236/abb.2017.81003]
[http://dx.doi.org/10.22207/JPAM.11.3.10]
[http://dx.doi.org/10.1007/s11356-017-9805-8]
[http://dx.doi.org/10.22207/JPAM.11.3.10]
[http://dx.doi.org/10.1080/13102818.2018.1441747]
[http://dx.doi.org/10.4172/2325-9655.1000143]
[http://dx.doi.org/10.1007/s10068-018-0323-3]
[http://dx.doi.org/10.1371]
[http://dx.doi.org/10.1016/j.bmc.2011.07.017]
[http://dx.doi.org/10.2174/1871520611313040010]
[http://dx.doi.org/10.1080/14786419.2015.1046871]
[http://dx.doi.org/10.1080/14786419.2015.1055266]
[http://dx.doi.org/10.1023/B:WATE.0000019938.57041.21]
[http://dx.doi.org/10.1080/02757540512331323953]
[http://dx.doi.org/10.4236/jep.2016.712145]
[http://dx.doi.org/10.2174/1389201020666190619092502]
[http://dx.doi.org/10.3184/095422910X12894975123773]
[http://dx.doi.org/10.4236/abb.2012.37101]
[http://dx.doi.org/10.1016/j.ejmech.2010.01.065]
[http://dx.doi.org/10.1016/0006-2952(61)90145-9]
[http://dx.doi.org/10.1186/1756-0500-3-348]
[http://dx.doi.org/10.1016/j.jinorgbio.2011.05.011]
[http://dx.doi.org/10.1016/j.foodchem.2005.11.031]
[http://dx.doi.org/10.3844/ajidsp.2009.135.141]
[http://dx.doi.org/10.3390/molecules20011118]
[http://dx.doi.org/10.1055/s-2002-20058]
[http://dx.doi.org/10.1016/j.lfs.2014.09.031]
[http://dx.doi.org/10.3390/nu6115184]
[http://dx.doi.org/10.1016/j.carres.2018.02.011]
[http://dx.doi.org/10.1186/1476-511X-12-115]
[http://dx.doi.org/10.1016/j.nutres.2010.08.008]
[http://dx.doi.org/10.1590/S0102-695X2013005000025]
[http://dx.doi.org/10.1016/j.leukres.2008.07.025]
[http://dx.doi.org/10.1038/nrc1588]
[http://dx.doi.org/10.1016/j.bcp.2008.07.031]
[http://dx.doi.org/10.1215/15228517-2008-085]
[http://dx.doi.org/10.1016/S0300-483X(96)03412-9]
[http://dx.doi.org/10.1021/bi300531c]
[http://dx.doi.org/10.1017/S000711450765795X]
[http://dx.doi.org/10.1111/j.1753-4887.2010.00287.x]
[http://dx.doi.org/10.1079/PNS2002166]
[http://dx.doi.org/10.1079/BJN20051626]
[http://dx.doi.org/10.1089/jmf.2006.092]
[http://dx.doi.org/10.1080/01635580701365068]
[http://dx.doi.org/10.3390/ijms19113285]