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Current Bioactive Compounds

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Review Article

Bioactive Compounds and Distinctive Pharmacological Activity Guided Review of Aegle marmelos: A Miraculous Plant of Indigenous Medicine System

Author(s): Sourav Ghosh*, Arvind Kumar, Neetu Sachan and Phool Chandra

Volume 16, Issue 7, 2020

Page: [965 - 977] Pages: 13

DOI: 10.2174/1573407215666191101091412

Price: $65

Abstract

Background: It is always thought that traditional herbal drugs are safe, effective and economical and are used worldwide for healing purposes. Aegle marmelos, belonging to family Rutaceae, is an important medicinal plant of the indigenous medicine system in India. Despite the study on ethnobotanical uses and the presence of bioactive compounds, there was only a handful of research on A. marmelos. The therapeutic use of bioactive compounds is not explored properly.

Objective: The objective of this study is to provide comprehensive data on the botanical description, ethnobotany, isolated bioactive compounds and their therapeutic effects according to the pharmacology of A. marmelos and its future prospects for further scientific investigation for the development of effective bioactive compounds.

Methods: Literature searches were performed in various databases, such as PubMed, SciFinder and Google Scholar, for peer-reviewed research literature pertaining to the bioactive compounds present and distinctive pharmacological activities of A. marmelos.

Results: The literature review indicates that different parts of A. marmelos possess various ethnobotanical uses. A large number of bioactive compounds isolated from different parts of the plant were reviewed which mainly belong to alkaloids, terpenoids, steroids, coumarins, flavonoids and carbohydrate in nature. The plant also possesses a wide range of pharmacological activities, such as antidiarrheal, antimicrobial, anticancer, hepatoprotective, antifertility, anti-inflammatory, wound healing, radioprotective, hypoglycemic and cardioprotective activity.

Conclusion: It is clearly proven that different parts of A. marmelos possess numerous therapeutic effects for treating various ailments of human beings. As the scientists anticipated to develop new drugs from natural sources, investigation of modern drugs from A. marmelos should be emphasized. Still, extensive research studies are required on A. marmelos as it is the most important plant of the indigenous medicine system in India. Therefore, this review could be used as a good source of information for researchers who wish to proceed their exploration of A. marmelos.

Keywords: Aegle marmelos, bioactive compounds, therapeutic use, ethnobotany, phytochemistry, pharmacological activity.

Graphical Abstract

[1]
Vickers, A.; Zollman, C.; Lee, R. Herbal medicine. West. J. Med., 2001, 175(2), 125-128.
[http://dx.doi.org/10.1136/ewjm.175.2.125 ] [PMID: 11483560]
[2]
Beidokhti, M.N.; Prakash, D. Antioxidant and anti-inflammatory potential of selected medicinal plants of Lamiaceae family. Int. J. Pharm. Pharm. Sci., 2013, 5(Suppl. 1), 100-104.
[3]
Chopra, R. Indigenous drugs of India; Academic publishers: Calcutta, 1982.
[4]
Baliga, M.S.; Harshith, P.; Bhat, H.P.; Josepha, N.; Fazala, F. Phytochemistry and medicinal uses of the bael fruit (Aegle marmelos Correa): A concise review. Food Res. Int., 2011, 44(7), 1768-1775.
[http://dx.doi.org/10.1016/j.foodres.2011.02.008]
[5]
Mahapatra, D.K.; Patil, S.; Patil, A.G. The progressive journey of phytosomes in herbal based pharmacotherapeutics. Curr. Bioact. Compd., 2019, 15, 1.
[http://dx.doi.org/10.2174/1573407215666190417121237]
[6]
Bhar, K.; Mondal, S.; Suresh, P. An eye-catching review of Aegle marmelos L. (Golden Apple). Pharmacogn. J., 2019, 11(2), 207-224.
[http://dx.doi.org/10.5530/pj.2019.11.34]
[7]
Orwa, C.; Mutua, A.; Kindt, R.; Jamnadass, R.; Anthony, S. Agroforestry Database: A tree reference and selection guide version 4.0; World Agroforestry Centre: Kenya, 2009.
[8]
Krishnan Nambiar, V.; Jayanthi, P.; Samu, T.K. Pharmacognostical studies on vilva-Aegle marmelos (Linn.) Corr. E Journal of Indian Medicine, 2000, 13(2), 73-96.
[9]
Marg, K.S.K. The Wealth of India: Raw Materials Series; Publications and Information Directorate: New Delhi, 1989.
[10]
Dhankhar, S.; Ruhil, S.; Balhara, M.; Dhankhar, S.; Chhillar, A.K. Aegle marmelos. Linn (correa): A potential source of phytomedicine. J. Med. Plants Res., 2011, 5(9), 1497-1507.
[11]
Rawat, R.B.S.; Uniyal, R.C. National medicinal plant board committed for overall development of the sector. Agro. Bios. Med. Plant, 2003, 1, 12-16.
[12]
Parmar, C.; Kaushal, M.K. Aegle marmelos: Wild Fruits; Kalyani Publishers: New Delhi, 1982.
[13]
Tomar, J.B.; Bishnoi, S.K.; Saini, K.K. Healing the tribal way: Ethno-medicinal formulations used by the tribes of Jharkhand, India. Int. J. Med. Arom. Plants, 2012, 2(1), 97-105.
[14]
Smita, K.; Pandey, R. Studies on sacred groves of Ranchi district: traditional Way of conserving plants. Socioscan, 2010, 2(3), 19-22.
[15]
Kala, C.P. Traditional Ecological Knowledge, Sacred Groves and Conservation of Biodiversity in the Pachmarhi Biosphere Reserve of India. J. Environ. Prot. (Irvine Calif.), 2011, 2(7), 967-973.
[http://dx.doi.org/10.4236/jep.2011.27111]
[16]
Parvath, S.; Brindha, R. Ethnobotanical medicines of Animalai union. Anc. Sci. Life, 2003, 22(4), 166-168.
[PMID: 22557105]
[17]
Dutta, A.; Lal, N.; Naaz, M.; Ghosh, A.; Verma, R. Ethnological and ethno-medicinal importance of Aegle marmelos (L.) Corr (Bael) among indigenous people of India. Am. J. Ethnomed., 2014, 1(5), 290-312.
[18]
Ariharan, V.N.; Nagendra, P.P. Mahavilva - A sacred tree with immense medicinal secrets: A mini review. Rasayan J. Chem., 2013, 6(4), 342-352.
[19]
Basu, D.; Sen, R. Alkaloids and Coumarins from root bark of Aegle marmelos. Phytochemistry, 1974, 13(10), 2329-2330.
[http://dx.doi.org/10.1016/0031-9422(74)85057-0]
[20]
Balunas, M.J.; Kinghorn, A.D. Drug discovery from medicinal plants. Life Sci., 2005, 78(5), 431-441.
[http://dx.doi.org/10.1016/j.lfs.2005.09.012 ] [PMID: 16198377]
[21]
George, K.V.; Mohanan, N.; Nair, S.S. Ethnobotanical investigations of Aegle marmelos (Linn.) Corr. Ethnbot. Med. Plants India and Nepal; Scientific Publishers: Jodhpur, 2003.
[22]
Rahman, A.; Said, H.M.; Ahmad, V.U. Pakistan encyclopaediaplantamedica; Hamdard foundation press: Karachi , 1986.
[23]
Veerappan, A.K.S.; Renganathan, D. In: Cardiotonic effect of Aegle marmelos Corr. On amphibian heart in situ preparation, Proceedings of the 6th Internet World Congress for Biomed. Sci, 2000.
[24]
Trivedi, V.P.; Nesamany, S.; Sharma, V.K. Ayurvedic herbs: A clinical guide to the healing plants of traditional medicine. J. Res. Ind. Med. Yoga Homeopath, 1978, 28, 13.
[25]
Vyas, D.S.; Sharma, V.N.; Sharma, H.K.; Khanua, N.K. Effect of labetalol, an alpha- & beta-adrenoceptor blocking agent on gastric acid secretion & gastric ulcers in pylorus- ligated rats J. Res. Indian med. Yoga homeopath , 1979, 14, 63.
[26]
Banerji, N.; Kumar, R. Study of endophytic fungal community from different parts of Aegle marmelos Correae (Rutaceae) from Varanasi (India). J. Inst. Chem. Soc., 1949, 71, 606.
[27]
Jain, N.K. Antifungal activity and kinetics of inhibition by essential oil isolated from leaves of Aegle marmelos. Indian Drugs Pharma., 1977, 12, 55.
[28]
Gupta, R. A sacred plant in Hindus. Int. J. Herb. Med., 2016, 4(4), 114-115.
[29]
Joshi, P. Fish stupefying plants employed by tribals of southern Rajasthan- A Probe. Curr. Sci., 1986, 55(14), 647-650.
[30]
Bhattacharjee, S.; Tiwari, K.C.; Majumdar, R.; Misra, A.K. Folklore medicine from district Kamrup (Assam). Bull. Medico-ethnobot Res, 1980, 1, 447-460.
[31]
Bhalla, N.P.; Sahu, T.R.; Mishra, G.P.; Dakwale, R.N. Traditional plant medicines of SagarDistt. Madhya Pradesh, India. J. Econ. Taxon. Bot., 1982, 3(1), 23-32.
[32]
Maity, P.; Hansda, D.; Bandyopadhyay, U.; Mishra, D.K. Biological activities of crude extracts and chemical constituents of Bael, Aegle marmelos (L.). Corr. Indian J. Exp. Biol., 2009, 47(11), 849-861.
[PMID: 20099458]
[33]
Manandhar, M.D.; Shoeb, A.; Kapil, R.S.; Popli, S.P. New alkaloids from Aegle marmelos. Phytochemistry, 1978, 17(1), 1814-1815.
[http://dx.doi.org/10.1016/S0031-9422(00)88714-2]
[34]
Nandkarni, A.K. Indian MateriaMedica, 3rd ed; Popular Prakashan: Bombay, 1976.
[35]
Sharma, B.R.; Rattan, R.K.; Sharma, P. Constituents of Aegle marmelos. Indian J. Chem., 1980, 19, 162.
[36]
Arul, V.; Miyazaki, S.; Dhananjayan, R. Mechanisms of the contractile effect of the alcoholic extract of Aegle marmelos Corr. on isolated guinea pig ileum and tracheal chain. Phytomedicine, 2004, 11(7-8), 679-683.
[http://dx.doi.org/10.1016/j.phymed.2002.12.001 ] [PMID: 15636185]
[37]
Murugesan, K.; Ezhilarasu, A.; Gajendiran, K. Phytochemical screening, antioxidant and antimicrobial activity of aeglemarmelas from kolli hills. Int. J. Interdisci Res. Revs., 2013, 1(5), 10-15.
[38]
Farooq, S. Medicinal plants- Field and laboratory manual; International Book Distributers: Dehradun, 2005.
[39]
Verma, R.S.; Padalia, R.C.; Chauhan, A. Essential oil composition of Aegle marmelos (L.) Correa: Chemotypic and seasonal variations. J. Sci. Food Agric., 2014, 94(9), 1904-1913.
[http://dx.doi.org/10.1002/jsfa.6510 ] [PMID: 24323871]
[40]
Barthakur, N.N.; Arnold, N.P. Cetrain organic and inorganic constituents in bael (Aegle marmelos) fruit. Trop. Agric., 1989, 66, 65-68.
[41]
Badam, L.; Bedekar, S.S.; Sonawane, K.B.; Joshi, S.P.; Joshi, S.P. In vitro antiviral activity of bael (Aegle marmelos Corr) upon human coxsackieviruses B1-B6. J. Commun. Dis., 2002, 34(2), 88-99.
[PMID: 14768825]
[42]
Chakthong, S.; Weaaryee, P.; Puangphet, P.; Mahabusarakam, W.; Plodpai, P.; Voravuthikunchai, S.P.; Kanjana-Opas, A. Alkaloid and coumarins from the green fruits of Aegle marmelos. Phytochemistry, 2012, 75, 108-113.
[http://dx.doi.org/10.1016/j.phytochem.2011.11.018 ] [PMID: 22196941]
[43]
Chatterjee, A.; Mitra, S.S. On the constitution of the active principles isolated from the mature bark of Aegle marmelos, Correâ. J. Am. Chem. Soc., 1949, 71(2), 606-609.
[http://dx.doi.org/10.1021/ja01170a062 ] [PMID: 18112067]
[44]
Mishra, A.; Bhatti, R.; Singh, A.; Singh Ishar, M.P. Ameliorative effect of the cinnamon oil from Cinnamomum zeylanicum upon early stage diabetic nephropathy. Planta Med., 2010, 76(5), 412-417.
[http://dx.doi.org/10.1055/s-0029-1186237 ] [PMID: 19876811]
[45]
Singh, Z.; Malik, A.U. The Bael.West Australian Nut and Tree Crops Association Yearbook; , 2000, 24, pp. 12-17.
[46]
Shoeb, A.; Randhir, S.K.; Popli, S. Coumarins and alkaloids of Aegle marmelos. Phytochemistry, 1973, 12, 2071-2072.
[http://dx.doi.org/10.1016/S0031-9422(00)91550-4]
[47]
Riyanto, S.; Sukari, M.A.; Rahmani, M. Alkaloids from A. marmelos (Rutaceae). Malays. J. Anal. Sci., 2001, 7(2), 463465.
[48]
Lone, R.; Shuab, R.; Kou, K.K. Role of cinnamate and cinnamate derivatives in pharmacology. Glob. J. Pharmacol., 2014, 8(3), 328-335.
[49]
Saravanan, M.; Pandikumar, P.; Saravanan, S.; Toppo, E.; Pazhanivel, N.; Ignacimuthu, S. Lipolytic and antiadipogenic effects of (3,3-dimethylallyl) halfordinol on 3T3-L1 adipocytes and high fat and fructose diet induced obese C57/BL6J mice. Eur. J. Pharmacol., 2014, 740, 714-721.
[http://dx.doi.org/10.1016/j.ejphar.2014.06.004 ] [PMID: 24952133]
[50]
Ratheesh, M.; Sindhu, G.; Helen, A. Anti-inflammatory effect of quinoline alkaloid skimmianine isolated from Ruta graveolens L. Inflamm. Res., 2013, 62(4), 367-376.
[http://dx.doi.org/10.1007/s00011-013-0588-1 ] [PMID: 23344232]
[51]
Judit, M.; Imre, O.; Laszlo, P.; Tannaz, G.; Judit, H.; István, Z. Investigation of the antiproliferative action of the quinoline alkaloids kokusaginine and skimmianine on human cell lines. Curr. Signal Transduct. Ther., 2013, 8(2), 148-155.
[http://dx.doi.org/10.2174/15743624113086660006]
[52]
Phuwapraisirisan, P.; Puksasook, T.; Jong-Aramruang, J.; Kokpol, U. Phenylethyl cinnamides: A new series of alpha-glucosidase inhibitors from the leaves of Aegle marmelos. Bioorg. Med. Chem. Lett., 2008, 18(18), 4956-4958.
[http://dx.doi.org/10.1016/j.bmcl.2008.08.024 ] [PMID: 18760601]
[53]
Pynam, H.; Dharmesh, S.M. Antioxidant and anti-inflammatory properties of marmelosin from Bael (Aegle marmelos L.); Inhibition of TNF-α mediated inflammatory/tumor markers. Biomed. Pharmacother., 2018, 106, 98-108.
[http://dx.doi.org/10.1016/j.biopha.2018.06.053 ] [PMID: 29957472]
[54]
Kim, J.H.; Kim, J.K.; Ahn, E.K.; Ko, H.J.; Cho, Y.R.; Lee, C.H.; Kim, Y.K.; Bae, G.U.; Oh, J.S.; Seo, D.W. Marmesin is a novel angiogenesis inhibitor: Regulatory effect and molecular mechanism on endothelial cell fate and angiogenesis. Cancer Lett., 2015, 369(2), 323-330.
[http://dx.doi.org/10.1016/j.canlet.2015.09.021 ] [PMID: 26455771]
[55]
He, W.; Chen, W.; Zhou, Y.; Tian, Y.; Liao, F. Xanthotoxol exerts neuroprotective effects via suppression of the inflammatory response in a rat model of focal cerebral ischemia. Cell. Mol. Neurobiol., 2013, 33(5), 715-722.
[http://dx.doi.org/10.1007/s10571-013-9939-2 ] [PMID: 23619720]
[56]
Kozioł, E.; Skalicka-Woźniak, K. Imperatorin-pharmacological meaning and analytical clues: Profound investigation. Phytochem. Rev., 2016, 15, 627-649.
[http://dx.doi.org/10.1007/s11101-016-9456-2 ] [PMID: 27453708]
[57]
Capra, J.C.; Cunha, M.P.; Machado, D.G.; Zomkowski, A.D.; Mendes, B.G.; Santos, A.R.; Pizzolatti, M.G.; Rodrigues, A.L. Antidepressant-like effect of scopoletin, a coumarin isolated from Polygala sabulosa (Polygalaceae) in mice: Evidence for the involvement of monoaminergic systems. Eur. J. Pharmacol., 2010, 643(2-3), 232-238.
[http://dx.doi.org/10.1016/j.ejphar.2010.06.043 ] [PMID: 20599906]
[58]
Panno, M.L.; Giordano, F. Effects of psoralens as anti-tumoral agents in breast cancer cells. World J. Clin. Oncol., 2014, 5(3), 348-358.
[http://dx.doi.org/10.5306/wjco.v5.i3.348 ] [PMID: 25114850]
[59]
Mazimba, O. Umbelliferone: Sources, chemistry and bioactivities review. Bull. Fac. Pharm. Cairo Univ., 2017, 55(2), 223-23.
[60]
Nugroho, A.; Riyanto, S.; Sukari, M.A.; Maeyama, K. Anti-allergic effects of Marmin, a coumarine isolated from Aegle marmelos Correa: In vitro study. Int. J. Phytomed., 2011, 3, 84-97.
[61]
Nirmal, S.A.; Pal, S.C.; Mandal, S.C.; Patil, A.N. Analgesic and anti-inflammatory activity of β-sitosterol isolated from Nyctanthes arbortristis leaves. Inflammopharmacology, 2012, 20(4), 219-224.
[http://dx.doi.org/10.1007/s10787-011-0110-8 ] [PMID: 22207496]
[62]
Plat, J.; Mensink, R.P. Effects of plant sterols and stanols on lipid metabolism and cardiovascular risk. Nutr. Metab. Cardiovasc. Dis., 2001, 11(1), 31-40.
[PMID: 11383323]
[63]
Panda, S.; Jafri, M.; Kar, A.; Meheta, B.K. Thyroid inhibitory, antiperoxidative and hypoglycemic effects of stigmasterol isolated from Butea monosperma. Fitoterapia, 2009, 80(2), 123-126.
[http://dx.doi.org/10.1016/j.fitote.2008.12.002 ] [PMID: 19105977]
[64]
Lim, J.C.; Park, J.H.; Budesinsky, M.; Kasal, A.; Han, Y.H.; Koo, B.S.; Lee, S.I.; Lee, D.U. Antimutagenic constituents from the thorns of Gleditsia sinensis. Chem. Pharm. Bull. (Tokyo), 2005, 53(5), 561-564.
[http://dx.doi.org/10.1248/cpb.53.561] [PMID: 15863930]
[65]
Navarro, A.; De las Heras, B.; Villar, A. Anti-inflammatory and immunomodulating properties of a sterol fraction from Sideritis foetens Clem. Biol. Pharm. Bull., 2001, 24(5), 470-473.
[http://dx.doi.org/10.1248/bpb.24.470 ] [PMID: 11379762]
[66]
Pal, D.K.; Nandi, M. CNS activities of Celesia coromandeliane Vahl. in mice. Acta Pol. Pharm., 2005, 62(5), 355-361.
[67]
Bayala, B.; Bassole, I.H.; Gnoula, C.; Nebie, R.; Yonli, A.; Morel, L.; Figueredo, G.; Nikiema, J.B.; Lobaccaro, J.M.; Simpore, J. Chemical composition, antioxidant, anti-inflammatory and anti-proliferative activities of essential oils of plants from Burkina Faso. PLoS One, 2014, 9(3), e92122.
[http://dx.doi.org/10.1371/journal.pone.0092122 ] [PMID: 24662935]
[68]
Basholli-Salihu, M.; Schuster, R.; Hajdari, A.; Mulla, D.; Viernstein, H.; Mustafa, B.; Mueller, M. Phytochemical composition, anti-inflammatory activity and cytotoxic effects of essential oils from three Pinus spp. Pharm. Biol., 2017, 55(1), 1553-1560.
[http://dx.doi.org/10.1080/13880209.2017.1309555 ] [PMID: 28385055]
[69]
Mohammadhosseini, M.; Venditti, A.; Sarker, S.; Nahar, L.; Akbarzadeh, A. The genus Ferula: Ethnobotany, phytochemistry and bioactivities - A review. Ind. Crops Prod., 2019, 129, 350-394.
[http://dx.doi.org/10.1016/j.indcrop.2018.12.012]
[70]
Jamshidi, A.; Khanzadi, S.; Azizi, M.; Azizzadeh, M.; Hashemi, M. Modeling the growth of Staphylococcus aureus as affected by black zira (Bunium persicum) essential oil, temperature, pH and inoculum levels. Vet. Res. Forum, 2014, 5(2), 107-114.
[PMID: 25568703]
[71]
Panche, A.N.; Diwan, A.D.; Chandra, S.R. Flavonoids: An overview. J. Nutr. Sci., 2016., 5e47
[http://dx.doi.org/10.1017/jns.2016.41] [PMID: 28620474]
[72]
Kilcoyne, M.; Joshi, L. Carbohydrates in therapeutics. Cardiovasc. Hematol. Agents Med. Chem., 2007, 5(3), 186-197.
[http://dx.doi.org/10.2174/187152507781058663 ] [PMID: 17630944]
[73]
Kumar, K.P.S.; Umadevi, M.; Bhowmik, D.; Singh, D.M.; Dutta, A.S. Recent trends in medicinal uses and health benefits of Indian traditional herbs Aegle marmelos. Pharma Innovation, 2012, 1(4), 5765.
[74]
Bramhachari, P.V.; Reddy, Y.K. Phytochemical examination, Antioxidant and radical scavenging activity of A. marmelos (L.) Correa extracts. J. Pharm. Res., 2010, 3(12) 30233025
[75]
Patkar, A.N.; Desai, N.V.; Ranage, A.A.; Kalekar, K.S. A Review on Aegle marmelos: A potential medicinal tree. Int. Res. J. Pharm., 2012, 3(8), 8691.
[76]
Sivraj, R.; Balakrishnan, A. Preliminary phytochemical analysis of Aegle marmelos. Int. J. Pharm. Sci. Res., 2011, 2(1), 146150.
[77]
Daniel, M. Medicinal plants chemistry and properties of medicinal plant; IBH publication: Florida, 2006.
[78]
Lambole, V.B.; Murti, K.; Kumar, U.; Bhatt, S.P.; Gajera, V. Phytopharmacological properties of Aegle marmelos as a potential medicinal tree: An overview. Int. J. Pharm. Sci. Rev. Res., 2010, 5(2), 67-72.
[79]
Harijagannadha, R.G. Lakshmi, P. Evaluation of Antidiarrhoeal activity of extract from leaves of Aegle marmelos. J. Appl. Pharm. Sci., 2012, 2(2), 75-78.
[80]
Mazumder, R.; Bhattacharya, S.; Mazumder, A.; Pattnaik, A.K.; Tiwary, P.M.; Chaudhary, S. Antidiarrhoeal evaluation of Aegle Marmelos (Correa) Linn. root extract. Phytother. Res., 2006, 20(1), 82-84.
[http://dx.doi.org/10.1002/ptr.1804 ] [PMID: 16397850]
[81]
Brijesh, S.; Daswani, P.; Tetali, P.; Antia, N.; Birdi, T. Studies on the antidiarrhoeal activity of Aegle marmelos unripe fruit: Validating its traditional usage. BMC Complement. Altern. Med., 2009, 9, 47.
[http://dx.doi.org/10.1186/1472-6882-9-47 ] [PMID: 19930633]
[82]
Thangavel, K.; Sasikala, M.; Maridass, M. In vitro antibacterial potential of Aegle marmelos (L.) callus extract. Pharmacologyonline, 2008, 3, 190-196.
[83]
Faizi, S.; Farooqi, F.; Zikr-Ur-Rehman, S.; Naz, A.; Noor, F.; Ansari, F.; Ahmad, A.; Khan, S.A. Shahidine, a novel and highly labile oxazoline from Aegle marmelos: The parent compound of aegeline and related amides. Tetrahedron, 2009, 65(5), 998-1004.
[http://dx.doi.org/10.1016/j.tet.2008.11.088]
[84]
Chattopadhyay, R.R.; Bhattacharyya, S.K.; Medda, C.; Chanda, S.; Bag, A. A comparative evaluation of antibacterial potential of some plants used in Indian traditional medicine for the treatment of microbial infections. Braz. Arch. Biol. Technol., 2009, 52(5), 1123-1128.
[http://dx.doi.org/10.1590/S1516-89132009000500009]
[85]
Kothari, S.; Mishra, V.; Bharat, S.; Tonpay, S.D. Antimicrobial activity and phytochemical screening of serial extracts from leaves of Aegle marmelos (Linn.). Acta Pol. Pharm., 2011, 68(5), 687-692.
[PMID: 21928713]
[86]
Saradha, K.J.; Subba, B.R. Antibacterial activity of extracts from Aegle marmelos against standard pathogenic bacterial strains. Int. J. Pharm. Tech. Res., 2010, 2(3), 1824-1826.
[87]
Rasi, R.P.M.; Daniel, T.A. Study on the antibacterial activity of certain plant extracts. Biosci. Biotechnol. Res. Asia, 2011, 8(1), 353-355.
[http://dx.doi.org/10.13005/bbra/872]
[88]
Bilkis, Z.; Jamal, M.A.H.M.; Alam, K.; Islam, R. Assessment of the antimicrobial activities of Wood Apple (Aegle marmelos L.) seed extracts against selected fungal and bacterial strains. Antiinfect. Agents, 2017, 15, 33.
[http://dx.doi.org/10.2174/2211352515666170213100820]
[89]
Venkatesan, D.; Karunakaran, M.; Kumar, S.S.; Palaniswamy, P.; Ramesh, G. Antimicrobial activity of Aegle marmelos against pathogenic organism compared with control drug. Ethnobotanical Leaflets, 2009, 13, 968-974.
[90]
Rath, S.; Dubey, D.; Sahu, M.C.; Debata, N.K.; Padhy, R.N. Surveillance of multidrug resistance of 6 uropathogens in a teaching hospital and in vitro control by 25 ethnomedicinal plants used by an aborigine of India. Asian Pac. J. Trop. Biomed., 2012, 2(2), 818-829.
[http://dx.doi.org/10.1016/S2221-1691(12)60319-0]
[91]
Chockalingam, V.; Kadali, S.S.; Gnanasambantham, P. Antiproliferative and antioxidant activity of Aegle marmelos (Linn.) leaves in Dalton’s lymphoma ascites transplanted mice. Indian J. Pharmacol., 2012, 44(2), 225-229.
[http://dx.doi.org/10.4103/0253-7613.93854 ] [PMID: 22529480]
[92]
Lambertini, E.; Piva, R.; Khan, M.T.; Lampronti, I.; Bianchi, N.; Borgatti, M.; Gambari, R. Effects of extracts from Bangladeshi medicinal plants on in vitro proliferation of human breast cancer cell lines and expression of estrogen receptor alpha gene. Int. J. Oncol., 2004, 24(2), 419-423.
[http://dx.doi.org/10.3892/ijo.24.2.419 ] [PMID: 14719119]
[93]
Gupta, N.; Agrawal, R.C.; Shrivastava, V.; Roy, A.; Prasad, P. Aegle marmelos fruit extract prevents cyclophosphamide induced micronucleus formation in mice. Res. J. Pharm. Technol., 2011, 4(11), 1666-1668.
[94]
Jagetia, G.C.; Venkatesh, P.; Baliga, M.S. Aegle marmelos (L.) Correa inhibits the proliferation of transplanted Ehrlich ascites carcinoma in mice. Biol. Pharm. Bull., 2005, 28(1), 58-64.
[http://dx.doi.org/10.1248/bpb.28.58 ] [PMID: 15635164]
[95]
Pae, H.O.; Oh, H.; Yun, Y.G.; Oh, G.S.; Jang, S.I.; Hwang, K.M.; Kwon, T.O.; Lee, H.S.; Chung, H.T. Imperatorin, a furanocoumarin from Angelica dahurica (Umbelliferae), induces cytochrome c-dependent apoptosis in human promyelocytic leukaemia, HL-60 Cells. Pharmacol. Toxicol., 2002, 91(1), 40-48.
[http://dx.doi.org/10.1034/j.1600-0773.2002.910107.x ] [PMID: 12193260]
[96]
Lampronti, I.; Khan, M.T.H.; Bianchi, N.; Lambertini, E.; Piva, R.; Borgatti, M.; Gambari, R. Plants with antitumor properties: From biologically active molecules to drugs. Advances in Phytomedicine, 2006, 2, 45-63.
[http://dx.doi.org/10.1016/S1572-557X(05)02004-0]
[97]
Modi, H.; Patel, V.; Patel, K. Hepatoprotective activity of AegleMarrmelos against ethanol induced hepatotoxicity in rats. Asian J. Pharm. Clin. Res., 2012, 5, 164-167.
[98]
Jayachandra, K.; Sivaraman, T. Hepatoprotective effect of Aegle Marmelos (L.) corr. leaf powder (crude) against carbon tetrachloride-induced hepatic damage in albino rats. Int. J. Pharm. Sci. Rev. Res., 2011, 3(7), 1360-1363.
[99]
Sastry, A.V.S. GirijaSastry, V.; Naga Sandhya, G.; Srinivas, K. Phytochemical investigations and hepatoprotective effects of aqueous fruit extract of Aegle marmelos Corr. Int. J. Chem. Sci., 2011, 9(2), 900-910.
[100]
Agrawal, S.S.; Kumar, A.; Gullaiya, S.; Dubey, V.; Nagar, A.; Tiwari, P.; Dhar, P.; Singh, V. Antifertility activity of methanolic bark extract of Aegle marmelos (L.) in male wistar rats. Daru, 2012, 20(1), 94.
[http://dx.doi.org/10.1186/2008-2231-20-94 ] [PMID: 23351957]
[101]
Chauhan, A.; Agarwal, M. Reversible changes in the antifertility induced by Aegle marmelos in male albino rats. Syst Biol Reprod Med, 2008, 54(6), 240-246.
[http://dx.doi.org/10.1080/19396360802516856 ] [PMID: 19052962]
[102]
Chauhan, A.; Agarwal, M.; Kushwaha, S.; Mutreja, A. Suppression of fertility in male albino rats following the administration of 50% ethanolic extract of Aegle marmelos. Contraception, 2007, 76(6), 474-481.
[http://dx.doi.org/10.1016/j.contraception.2007.08.002 ] [PMID: 18061707]
[103]
Chauhan, A.; Agarwal, M. Assessment of the contraceptive efficacy of the aqueous extract of Aegle marmelos Corr. leaves in male albino rats. Hum. Fertil. (Camb.), 2009, 12(2), 107-118.
[http://dx.doi.org/10.1080/14647270802657402 ] [PMID: 19802961]
[104]
Sekar, D.K.; Kumar, G.; Karthik, L.; Bhaskara Rao, K.V. A review on pharmacological and phytochemical properties of Aegle marmelos (L.) Corr. Serr. (Rutaceae). Asian J. Plant Sci., 2011, 1(2), 8-17.
[105]
Bhalla, S.; Verma, M.; Rawal, S. Invitro antioxidant activity of the methanolic extract of Aegle marmelos Leaf. Int. J. Nat. Prod. Sci., 2012, 1(Sppl.), 185.
[106]
Siddique, N.A.; Mujeeb, M. Development of quality standards of Aegle marmelos leaves. J. Phytol., 2010, 2(2), 36-43.
[107]
George, M.; Joseph, L.; Sreelakshmi, R. Phytochemical and pharmacological screening of in vivo anti-inflammatory activity of Aegle marmelos (L.). Corr. Serr. J. Chem. Pharm. Res., 2016, 8(2), 330-334.
[108]
Kothari, S.; Minda, M.; Tonpay, S.D. Anxiolytic and antidepressant activities of methanol extract of Aegle marmelos leaves in mice. Indian J. Physiol. Pharmacol., 2010, 54(4), 318-328.
[PMID: 21675029]
[109]
George, M.; Joseph, L.; Sreelakshmi, R. Evaluation of antidepressant and antianxiety activity of ethanolic leaf extract of Aegle marmelos. Int. Res. J. Pharm. Appl. Sci., 2016, 6(1), 12-14.
[110]
Jaswant, A.; Loganathan, V.; Manimaran, S. Wound healing activity of Aegle marmelos. Indian J. Pharm. Sci., 2001, 63(1), 41-44.
[111]
Jagetia, G.C.; Venkatesh, P.; Baliga, M.S. Evaluation of the radioprotective effect of bael leaf (Aegle marmelos) extract in mice. Int. J. Radiat. Biol., 2004, 80(4), 281-290.
[http://dx.doi.org/10.1080/09553000410001679776 ] [PMID: 15204705]
[112]
Sharma, A.K.; Bharti, S.; Goyal, S.; Arora, S.; Nepal, S.; Kishore, K.; Joshi, S.; Kumari, S.; Arya, D.S. Upregulation of PPARγ by Aegle marmelos ameliorates insulin resistance and β-cell dysfunction in high fat diet fed-streptozotocin induced type 2 diabetic rats. Phytother. Res., 2011, 25(10), 1457-1465.
[http://dx.doi.org/10.1002/ptr.3442 ] [PMID: 21351301]
[113]
Babbar, O.P.; Joshi, M.N.; Madan, A.R. Evaluation of plants for antiviral activity. Indian J. Med. Res., 1982, 76(Suppl.), 54-65.
[PMID: 6193062]
[114]
Dhar, M.L.; Dhar, M.M.; Dhawan, B.N.; Mehrotra, B.N.; Ray, C. Screening of Indian plants for biological activity: I. Indian J. Exp. Biol., 1968, 6(4), 232-247.
[PMID: 5720682]
[115]
Behera, J.P.; Mohanty, B.; Ramani, Y.R.; Rath, B.; Pradhan, S. Effect of aqueous extract of Aegle marmelos unripe fruit on inflammatory bowel disease. Indian J. Pharmacol., 2012, 44(5), 614-618.
[http://dx.doi.org/10.4103/0253-7613.100389 ] [PMID: 23112424]
[116]
Rao, V.V.; Dwivedi, S.K.; Swarup, D.; Sharma, S.R. Hypoglycemic and antihyperglycemic effects of Aegle marmelos leaves in rabbits. Curr. Sci., 1995, 69(11), 932-933.
[117]
Chakarbarty, B.; Mallick, C.; Bhattacharya, S. Studies on the green leaves of Aegle marmelos and Piper nigrum on the glucose and cholesterol levels of blood in diabetes mellitus.Indian Medical Forum; , 1960, 9, pp. 285-286.
[118]
Sabu, M.C.; Kuttan, R. Antidiabetic activity of Aegle marmelos and its relationship with its antioxidant properties. Indian J. Physiol. Pharmacol., 2004, 48(1), 81-88.
[PMID: 15270373]
[119]
Karunanayake, E.H.; Welihinda, J.; Sirimanne, S.R.; Sinnadorai, G. Oral hypoglycaemic activity of some medicinal plants of Sri Lanka. J. Ethnopharmacol., 1984, 11(2), 223-231.
[http://dx.doi.org/10.1016/0378-8741(84)90040-0 ] [PMID: 6492834]
[120]
Upadhya, S.; Shanbhag, K.K.; Suneetha, G.; Balachandra Naidu, M.; Upadhya, S. A study of hypoglycemic and antioxidant activity of Aegle marmelos in alloxan induced diabetic rats. Indian J. Physiol. Pharmacol., 2004, 48(4), 476-480.
[PMID: 15907058]
[121]
Sachdewa, A.; Raina, D.; Srivastava, A.K.; Khemani, L.D. Effect of Aegle marmelos and Hibiscus rosa sinensis leaf extract on glucose tolerance in glucose induced hyperglycemic rats (Charles foster). J. Environ. Biol., 2001, 22(1), 53-57.
[PMID: 11480352]
[122]
Kar, A.; Choudhary, B.K.; Bandyopadhyay, N.G. Comparative evaluation of hypoglycaemic activity of some Indian medicinal plants in alloxan diabetic rats. J. Ethnopharmacol., 2003, 84(1), 105-108.
[http://dx.doi.org/10.1016/S0378-8741(02)00144-7 ] [PMID: 12499084]
[123]
Sharma, S.R.; Dwivedi, S.K.; Swarup, D. Antihyperglycemic and insulin release effects of Aegle marmelos leaves in streptozotocin diabetic rats. Phytother. Res., 1996, 10(5), 426-428.
[http://dx.doi.org/10.1002/(SICI)1099-1573(199608)10:5<426::AID-PTR861>3.0.CO;2-E]
[124]
Anandharajan, R.; Jaiganesh, S.; Shankernarayanan, N.P.; Viswakarma, R.A.; Balakrishnan, A. In vitro glucose uptake activity of Aegles marmelos and Syzygium cumini by activation of Glut-4, PI3 kinase and PPARgamma in L6 myotubes. Phytomedicine, 2006, 13(6), 434-441.
[http://dx.doi.org/10.1016/j.phymed.2005.03.008 ] [PMID: 16716914]
[125]
Gireesh, G.; Reas, S.K.; Jobin, M.; Paulose, C.S. Decreased muscarinic M1 receptor gene expression in the cerebral cortex of streptozotocin-induced diabetic rats and Aegle marmelose leaf extract’s therapeutic function. J. Ethnopharmacol., 2008, 116(2), 296-304.
[http://dx.doi.org/10.1016/j.jep.2007.11.036 ] [PMID: 18201849]
[126]
Haravey, S.K. A preliminary communication of the action of Aegle marmelos (Bael) on heart. Indian J. Med. Res., 1968, 56(3), 327-331.
[PMID: 5658493]
[127]
Kakiuchi, N.; Senaratne, L.R.E.; Huang, S.L.; Yang, X.W.; Hattori, M.; Pilapitiya, U.; Namba, T. Effects of constituents of Beli (Aegle marmelos) on spontaneous beating and calcium-paradox of myocardial cells. Planta Med., 1991, 57(1), 43-46.
[http://dx.doi.org/10.1055/s-2006-960014 ] [PMID: 2062957]
[128]
Prince, P.S.M.; Rajadurai, M. Preventive effect of Aegle marmelos leaf extract on isoprenaline-induced myocardial infarction in rats: Biochemical evidence. J. Pharm. Pharmacol., 2005, 57(10), 1353-1357.
[http://dx.doi.org/10.1211/jpp.57.10.0015 ] [PMID: 16259765]
[129]
Juvekar, A.R.; Bandawane, D.D. Antihyperglycaemic and antihyperlipidemic activity of Aegle marmelos Linn leaf extract in streptozotocin-induced diabetes rats. Indian Drugs, 2009, 46(7), 43-49.
[130]
Murugaiah, K.; Venkatachalam, R. Antispasmolytic and antihelminthiasis activity of aegeline isolated from Aegle marmelos leaves. J. Global BioSci., 2015, 4(1), 1235-1238.
[131]
Shankarananth, V.; Balakrishnan, N.; Suresh, D.; Sureshpandian, G.; Edwin, E.; Sheeja, E. Analgesic activity of methanol extract of Aegle marmelos leaves. Fitoterapia, 2007, 78(3), 258-259.
[http://dx.doi.org/10.1016/j.fitote.2006.12.004 ] [PMID: 17335994]

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