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Review Article

SGLT-2抑制剂对高血糖症的有益血流动力学作用

卷 27, 期 39, 2020

页: [6682 - 6702] 页: 21

弟呕挨: 10.2174/0929867326666191029111713

价格: $65

摘要

2型糖尿病（DM）是一种公共卫生负担，在代谢综合征的背景下，与高血压并存已久。糖尿病和高血压都是终末期肾脏疾病，心血管事件和死亡率的主要危险因素。糖尿病患者严格控制血压与降低心血管和肾脏风险有关。近端小管中的钠-葡萄糖共转运蛋白2（SGLT-2）抑制剂是用于治疗2型DM的相对较新的一类药物。 SGLT-2协同转运蛋白的抑制作用结合了近端小管利尿剂和渗透性利尿剂的作用，从而导致葡萄糖再吸收减少以及轻度利钠和利尿剂作用。在此基础上，数项研究表明，使用SGLT-2抑制剂治疗可以有效降低高血糖症，但也可以提高血压控制并降低肾脏结局和心血管死亡率。基于这些证据，最近的2型DM治疗指南建议，对于心血管风险增加，慢性肾脏疾病或心力衰竭的患者，SGLT-2抑制剂应优先于口服药物与二甲双胍联用。这篇综述总结了来自研究的现有数据，这些研究评估了SGLT-2抑制剂对BP的作用及其对心脏和肾脏保护的潜在价值。

关键词: 血压，SGLT-2抑制剂，依帕列净，坎格列净，达格列净，糖尿病（DM）。

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