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Review Article

强啡肽在疾病和发展中的作用：对心血管疾病的影响

卷 20, 期 4, 2020

页: [259 - 274] 页: 16

弟呕挨: 10.2174/1566524019666191028122559

价格: $65

摘要

众所周知，心血管疾病继续代表着日益严重的健康问题，并且已经做出了巨大努力来阐明其潜在机制。在这篇综述中，我们报告了内分泌网络信号传导领域过去和最近的高影响力出版物，特别关注阿片类药物及其与心血管系统关键调节剂和相关疾病发作的相互关系。我们对研究进行了概述，概述了受阿片类药物影响的心血管和脑血管过程的范围，包括心脏功能，局部缺血，再灌注和血流。特别强调强啡肽分子在脑血管和心血管调节中的重要性。有证据表明强啡肽的过量或不足可能对心血管生理起重要作用，然而，许多矛盾的观察经常阻碍对强啡肽作用的清楚理解。因此，我们认为不应将强啡肽介导的信号事件直接调节作用引起争议，因为它们可能在与其他信号网络的串扰中发挥作用。最后，我们考虑了强啡肽在心血管相关炎症中的作用以及κ-阿片受体（一种主要强啡肽A受体）的内源性和外源性抑制剂限制或预防心血管疾病及其相关后遗症的潜在价值。

关键词: 强啡肽，信号传导，心血管，I / R损伤，内分泌网络信号传导，阿片类药物。

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