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Endocrine, Metabolic & Immune Disorders - Drug Targets

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ISSN (Print): 1871-5303
ISSN (Online): 2212-3873

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Research Article

The Association of Potassium Status with Parameters of Glucose Metabolism is influenced by Age in Adults

Author(s): Ibrahim Elmadfa, Alexa L. Meyer, Verena Hasenegger, Thomas Moeslinger and Cem Ekmekcioglu*

Volume 20, Issue 5, 2020

Page: [788 - 796] Pages: 9

DOI: 10.2174/1871530319666191028100109

Price: $65

Abstract

Background: Potassium status has been found to affect glucose homeostasis.

Objective: This study therefore aimed at investigating relationships between potassium status or dietary intake and fasting plasma glucose (FPG) or glycated haemoglobin (HbA1c) in a sample of Austrian adults (18-80 years, n = 421, 61% women) from the Austrian Study on Nutritional Status 2012.

Methods: Dietary potassium intake was obtained by two 24 h recalls. FPG, plasma K+, and urinary K+ were determined photometrically, HbA1c by HPLC. Associations between the parameters were studied using multiple regression analysis after controlling for confounders and after age stratification of the sample (18-64 y vs. 65-80 y).

Results: Most of the participants had a potassium intake of less than the estimated adequate daily intake of 4000 mg/d. In the multiple regression analyses in the whole sample plasma K+ had a statistically significant positive effect on FPG only in the crude model (ß = 0.128, p < 0.01) and on HbA1c also in the fully adjusted model (ß = 0.129, p < 0.05). The small effects on HbA1c were also detected in the younger age group but were absent in the older population. However, in this latter, a reverse association of urinary K+ on HbA1c was observed as well as of dietary potassium intake on FPG with no effects in the younger sample.

Conclusion: We suggest that age dependent differences in the association between parameters of potassium status and blood glucose regulation should also be taken into account.

Keywords: Potassium, biochemical status, intake, fasting plasma glucose, HbA1c, age.

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