Drug Target Discovery by Gene Expression Analysis Cell Cycle Genes

Title: Drug Target Discovery by Gene Expression Analysis Cell Cycle Genes

Volume: 1 Issue: 1

Author(s): M. G. Walker

Affiliation:

Keywords: Gene Expression Analysis, hepatitis B viral protein, Fisher Exact test, Bonferroni, papillomavirus, hypothetical genes

Abstract: Gene expression microarrays and gene expression databases provide new opportunities for the discovery of drug targets and for determination of a drugs mode of action. We review gene expression analysis methods and describe studies that have identified cell cycle genes using differential expression analysis and co-expression analysis. We present an example of the identification of previously-unrecognized human cell cycle genes, CDCA1 through CDCA8, that are co-expressed with known cell cycle genes including CDC2, CDC7, CDC23, cyclin, MCAK, mki67a, topoisomerase II, and others.

Cite this article as:

Walker G. M., Drug Target Discovery by Gene Expression Analysis Cell Cycle Genes, Current Cancer Drug Targets 2001; 1 (1) . https://dx.doi.org/10.2174/1568009013334241