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Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

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ISSN (Print): 1871-5230
ISSN (Online): 1875-614X

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Review Article

The Trinity of Matrix Metalloproteinases, Inflammation, and Cancer: A Literature Review of Recent Updates

Author(s): Erva Ozkan and Filiz Bakar-Ates*

Volume 19, Issue 3, 2020

Page: [206 - 221] Pages: 16

DOI: 10.2174/1871523018666191023141807

Abstract

The critical link between cancer and inflammation has been known for many years. This complex network was further complexed by revealing the association of the matrix metalloproteinase family members with inflammatory cytokines, which were previously known to be responsible for the development of metastasis. This article summarizes the current studies which evaluate the relationship between cancer and inflammatory microenvironment as well as the roles of MMPs on invasion and metastasis together.

Keywords: Cancer, cytokine, inflammation, matrix metalloproteinase, TIMP, inhibitors.

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Graphical Abstract

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