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当代阿耳茨海默病研究

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ISSN (Print): 1567-2050
ISSN (Online): 1875-5828

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Review Article

阿尔茨海默病和视网膜变性：眼液和组织中必需微量金属的发现

卷 16, 期 12, 2019

页: [1073 - 1083] 页: 11

弟呕挨: 10.2174/1567205016666191023114015

价格: $65

摘要

背景：尽管神经退行性疾病可能会严重影响老年人的个体活动，但世界各地的预期寿命都在增加。其中，阿尔茨海默氏病（AD）是工业化国家中最具有社会成本的与年龄相关的疾病之一。迄今为止，视网膜疾病在发展中国家似乎更为普遍，并且主要是老年人。年龄相关性黄斑变性（AMD）是一种迟发性神经退行性视网膜疾病，与AD具有多种临床和病理特征，包括氧化应激，炎症和淀粉样蛋白形成等应激刺激。 方法：在两种疾病中，有害的细胞内/细胞外沉积物都有许多相似之处。衰老，高胆固醇血症，高血压，肥胖，动脉硬化和吸烟是发展这两种疾病的危险因素。细胞衰老的途径在视网膜和大脑中具有相似的细胞器和信号传导模式。寻找新的研究策略的可能性代表了向他们披露潜在的治疗方法的进步。必需的微量金属主要通过影响复杂的多因素发病机制来影响代谢过程，从而在视网膜，视神经和大脑的生理和病理状况中都起着至关重要的作用。 结论：因此，本综述针对与AD和AMD相关的一些最新调查的必需微量金属提供了当前知识。全身和眼部液体中必需金属水平的变化可能反映了AMD的早期阶段，可能揭示了与AD共享的神经退行性途径，这可能为潜在的早期发现打开了大门。

关键词: 金属示踪剂，早期诊断，阿尔茨海默氏病，与年龄有关的黄斑变性，铜，眼液

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