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当代阿耳茨海默病研究

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ISSN (Print): 1567-2050
ISSN (Online): 1875-5828

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Research Article

血糖控制与中国农村老年人2型糖尿病的认知功能障碍有关。

卷 16, 期 10, 2019

页: [950 - 962] 页: 13

弟呕挨: 10.2174/1567205016666191023110712

价格: $65

摘要

背景：对2型糖尿病（T2DM）患者的认知障碍（CI）的兴趣日益增加，但有关CI与血糖控制之间的关联的证据却相互矛盾。目的：本研究旨在评估中国北方农村地区T2DM患者的CI患病率，以确定认知功能障碍是否与血糖控制有关。 方法：首先，我们进行了横断面设计研究。我们对居住在中国农村的60岁以上的1848名居民进行了整群随机抽样。对所有有或没有T2DM的合格参与者进行了访谈，并筛选了其认知功能状态。痴呆症和无认知障碍痴呆症（CIND）的诊断基于标准标准。其次，根据横断面调查的结果，我们进行了病例对照研究。在T2DM组中，我们确定了具有认知障碍的T2DM病例（T2DM-CI）和具有正常认知的T2DM病例（T2DM-NC）作为对照。检查了特定糖尿病相关变量的影响。在对T2DM-CI和T2DM-NC组中的性别，年龄和教育水平进行匹配后，进行了多因素Logistic回归分析以评估T2DM-CI的危险因素。 结果：在横断面研究中，伴有CIND和痴呆的T2DM患病率分别为28.3％（95％CI：23.5-33.2）和9.5％（95％CI：6.3-12.6）。与没有DM的受试者相比，在几乎每个年龄组中，T2DM患者的CI患病率都比普通人群中CI患病率高。在病例对照研究中，多因素logistic回归分析表明，变量（包括糖尿病发作的持续时间，糖化血红蛋白A1c水平（HbA1c）和严重的低血糖病史）与T2DM患者CI风险增加显着相关（几率比[OR] [95％CI]：1.67 [1.03-2.70]，1.40 [1.15-1.72]和2.72 [1.02-7.21] [P <0.05]）。 结论：本研究表明，在中国农村的老年人口中，T2DM患者的CI发生率很高。血糖控制（包括HbA1c和暴露于严重的低血糖症）会影响T2DM患者的认知功能。

关键词: 认知障碍，痴呆，HbA1c，低血糖，2型糖尿病（T2DM），中国农村。

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