Candida Proteases and Their Inhibition Prospects for Antifungal Therapy

Title: Candida Proteases and Their Inhibition Prospects for Antifungal Therapy

Volume: 8 Issue: 8

Author(s): K. Stewart and C. Abad-Zapatero

Affiliation:

Keywords: Candida Proteases, Antifungal Therapy, secreted acid proteases (SAP), Candida fungal species, fluconazole, echinocandin B, amphotericin, HIV PROTEASE INHIBITORS

Abstract: The rationale for inhibition of the secreted acid proteases (SAP) of Candida fungal species as a novel antifungal strategy is outlined. Enzyme structure-activity relationship data regarding the inhibitor A-70450 are described along with results from in vivo antifungal assays. Developments from protein X-ray crystallographic studies, SAP knock-out genetic studies, and the importance of these new results for drug discovery are reviewed. Finally, inhibition of the Candida SAP enzymes with HIV protease inhibitors and a proposed role in candidiasis of AIDS patients is discussed.

Cite this article as:

Stewart K. and Abad-Zapatero C., Candida Proteases and Their Inhibition Prospects for Antifungal Therapy, Current Medicinal Chemistry 2001; 8 (8) . https://dx.doi.org/10.2174/0929867013372698