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Review Article

来自日本海洋生物的药物先导物

卷 28, 期 1, 2021

发表于: 22 October, 2019

页: [196 - 210] 页: 15

弟呕挨: 10.2174/0929867326666191022125851

价格: $65

摘要

从海洋生物中获得了许多具有非凡化学结构和卓越生物活性的天然产物。我们通过对这些生物活性分子的研究，探索了有机化学和生物科学的新前沿，例如强大的海洋毒素水螅毒素A和抗癌药物HalavenR的抗肿瘤分子大田软海绵素B。我们在传统学科内工作，试图获得对生物现象的更深入的理解。我们在这里介绍我们的主要工作以及最新的主题。我们从海洋蓝藻中分离出水螅毒素A，并完成了克级合成。水螅毒素 A是一种新型聚酮，可抑制3T3-L1细胞向脂肪细胞分化，但细胞毒性不显著。具体的作用机制将通过进一步的体外和体内实验来阐明。在本研究中，我们探索冈田酸和大田软骨素B的真正生产者，通过免疫染色冈田软骨素抗体制备这些天然产物作为抗原。我们将分析分离的共生体并揭示生物合成途径。

关键词: 天然产物，大田软海绵素B

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