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Current Green Chemistry

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ISSN (Print): 2213-3461
ISSN (Online): 2213-347X

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Mini-Review Article

Green Protocols for the Synthesis of 3,3’-spirooxindoles – 2016- mid 2019

Author(s): Ani Deepthi*, Noble V. Thomas and Vidya Sathi

Volume 6, Issue 3, 2019

Page: [210 - 225] Pages: 16

DOI: 10.2174/2213346106666191019144116

Abstract

Spirooxindoles, particularly 3,3’-spirooxindoles constitute a privileged structural scaffold owing to the intensive biological activities which they possess. Because of this over the last twenty years, a large number of methods were devised for their synthesis and some of these molecules have entered pre-clinical trials. Of late, methods for spirooxindole synthesis using green protocols have developed rapidly. Reactions based on multicomponent strategies using non-catalytic / biocatalytic pathways and those done in aqueous media have been largely employed for the synthesis of 3,3’- spirooxindoles. This review focusses on the synthesis of 3,3’-spirooxindoles via green protocols and covers the literature from 2016 onwards (2016 - mid 2019); a review on the same topic has appeared in 2016. The green methods discussed here include reactions done in aqueous media, multicomponent strategies, alternate solvents and photocatalysis.

Keywords: 3, 3'-spirooxindoles, multicomponent reactions, spiropyrans, spiropyrrolidines, catalysts, green.

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