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Current Organic Chemistry

Editor-in-Chief

ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

General Review Article

Synthesis of Pyrimidine-Annulated Five-Membered Heterocycles: An Overview

Author(s): Pradip Kumar Maji*

Volume 23, Issue 20, 2019

Page: [2204 - 2269] Pages: 66

DOI: 10.2174/1385272823666191019111627

Price: $65

Abstract

This review describes the non-exhaustive scenery of the synthesis of various biologically interesting pyrimidine annulated five-membered heterocyclic ring systems that have been appeared in the literature during the last two decades. During this period, different synthetic routes and various methodologies have been developed for the functionalization of pyrimidine ring towards the construction of five-membered heterocyclic rings. The aim of this review is to give an overview of the assorted methodologies that have been reported about the chemistry of construction of pyrimidines annulated nitrogen, oxygen and sulphur containing five-membered heterocycles.

Keywords: Pyrimidine annulated heterocycles, furopyrimidine, thienopyrimidine, pyrrolopyrimidine, imidazopyrimidine, indolopyrimidine, pyrazolopyrimidine, triazolopyrimidine.

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