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Current Organic Synthesis

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ISSN (Print): 1570-1794
ISSN (Online): 1875-6271

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Research Article

Solvent-mediated Highly Efficient Synthesis of [1,2,4]triazolo/benzimidazoloquinazolinone Derivatives

Author(s): Fatemeh Malamiri, Samad Khaksar*, Rashid Badri and Elham Tahanpesar

Volume 16, Issue 8, 2019

Page: [1185 - 1190] Pages: 6

DOI: 10.2174/1570179416666191018145142

Price: $65

Abstract

Objective: An efficient and catalyst-free procedure for the synthesis of [1,2,4]triazolo/benzimidazolo quinazolinones has been developed in 2,2,2-trifluoroethanol or deep eutectic solvent(DESs) as a clean reaction media.

Methods: All of the obtained products are known compounds and identified by IR, 1HNMR,13CNMR, and melting points.

Result: Various products were obtained in good to excellent yields under reaction conditions.

Conclusion: We have efficiently developed a practical and catalyst-free approach for the synthesis of [1,2,4]triazolo/benzimidazolo quinazolinones employing TFE as a clean and reusable media.

Keywords: Fluorinated alcohols, green chemistry, triazole, multicomponent, heterocyclic, anticancer.

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