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Current Stem Cell Research & Therapy

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ISSN (Print): 1574-888X
ISSN (Online): 2212-3946

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General Review Article

Stem Cells from Human Exfoliated Deciduous Teeth: A Concise Review

Author(s): Chih-Sheng Ko, Jen-Hao Chen and Wen-Ta Su*

Volume 15, Issue 1, 2020

Page: [61 - 76] Pages: 16

DOI: 10.2174/1574888X14666191018122109

Price: $65

Abstract

Stem Cells from Human Exfoliated Deciduous Teeth (SHED) originate from the embryonic neural crest as ectodermal mesenchymal stem cells and are isolated from human deciduous teeth. SHED expresses the same cell markers as Embryonic Stem Cells (ESCs), such as OCT4 and NANOG, which make SHED to have a significant impact on clinical applications. SHED possess higher rates of proliferation, higher telomerase activity, increased cell population doubling, form sphere-like clusters, and possess immature and multi-differentiation capacity; such high plasticity makes SHED one of the most popular sources of stem cells for biomedical engineering. In this review, we describe the isolation and banking method, the current development of SHED in regenerative medicine and tissue engineering in vitro and in vivo.

Keywords: Stem cells from human exfoliated deciduous teeth, dental stem cells, isolation, banking, ESCs, HSCs.

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