In Silico Drug Repositioning for Chagas Disease

doi:10.2174/0929867326666191016114839
摘要

恰加斯病是一种传染性热带病，属于一种被忽视的热带病。尽管从历史上讲是拉丁美洲的地方病，但由于人类的迁徙，它最近已传播到高收入国家。目前，只有两种可用药物尼古丁酮和苯硝唑被批准用于这种治疗，它们都具有相当大的副作用（通常会导致治疗中断），并且在成人慢性疾病中疗效有限。药物重新定位涉及发现已知药物的新治疗适应症，包括已批准，撤销，放弃和研究用药物。由于适应症的转移是建立在现有安全性，ADME和制造信息的基础上的，因此今天它已成为开发创新药物的一种广泛应用的方法，从而大大缩短了开发时间。药物重新定位已成为一种特别有趣的策略，用于寻找被忽视和罕见疾病的新治疗方案，传统上，这种解决方案的商业兴趣有限，并且大多由公共部门以及非营利性计划和组织提供。在这里，我们回顾了计算机辅助技术在查加斯病领域中作为药物重新定位的系统方法的应用。计算机筛选是最受探索的方法，而其他合理方法（例如基于网络和基于签名的近似方法）尚未应用。
关键词: 药物再利用，药物重新定位，计算机筛查，虚拟筛查，恰加斯病，克鲁斯锥虫。
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DOI https://dx.doi.org/10.2174/0929867326666191016114839	Print ISSN 0929-8673
Publisher Name Bentham Science Publisher	Online ISSN 1875-533X
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