摘要
背景:百里香醌是一种很有前途的抗癌分子,其化学预防作用至少在体外和动物模型中是众所周知的。本文就百里香醌在肿瘤细胞中的抗炎作用作一综述。 方法:炎症、癌症和百里香醌的研究数据来自PubMed、Scopus、Web of Science和谷歌学术。我们回顾了自上世纪中叶以来发表的论文,以及近十年被引用次数最多的论文。 结果:研究表明,百里香醌除了具有化学预防作用外,还具有免疫调节活性。百里香醌可以靶向调节核因子κB (NF-κβ)、白细胞介素、肿瘤坏死因子-α(TNF-α)等炎症分子,以及某些生长因子。由于慢性炎症在肿瘤发生发展中起着重要作用,控制炎症通路是一种抗癌分子的重要机制,而调节炎症通路可能是百里香醌抗癌活性的关键机制之一。 结论:本文综述了炎症在肿瘤发生发展中的作用,以及百里醌对炎症分子的作用,并对其在体内外的研究进展进行了综述。研究百里醌在免疫治疗中的作用,并将其开发为未来的抗癌药物是十分必要的。
关键词: 癌症,百里香醌,免疫疗法,炎症调节剂,NF-κβ,不受控制的增殖。
[PMID: 17940618]
[http://dx.doi.org/10.3322/caac.21565] [PMID: 31184787]
[http://dx.doi.org/10.1038/nrc3611] [PMID: 24154716]
[http://dx.doi.org/10.1016/S0140-6736(00)04046-0] [PMID: 11229684]
[http://dx.doi.org/10.1002/ijc.23173] [PMID: 17893866]
[http://dx.doi.org/10.1038/nature01322] [PMID: 12490959]
[http://dx.doi.org/10.4161/cbt.12.2.15952] [PMID: 21623164]
[http://dx.doi.org/10.3389/fimmu.2018.00563] [PMID: 29662489]
[http://dx.doi.org/10.1021/np068054v] [PMID: 17309302]
[http://dx.doi.org/10.18632/oncotarget.17206] [PMID: 28881699]
[http://dx.doi.org/10.1016/j.biopha.2019.108783] [PMID: 31060003]
[http://dx.doi.org/10.1016/j.mrrev.2008.03.002] [PMID: 18485806]
[http://dx.doi.org/10.1007/s00423-006-0073-1] [PMID: 16909291]
[http://dx.doi.org/10.1093/carcin/bgp272] [PMID: 19955394]
[http://dx.doi.org/10.1038/nature02924] [PMID: 15329734]
[http://dx.doi.org/10.1007/s10495-009-0315-0] [PMID: 19212815]
[http://dx.doi.org/10.1074/jbc.M602097200] [PMID: 16857678]
[http://dx.doi.org/10.1042/CS20120651] [PMID: 24059588]
[http://dx.doi.org/10.1074/jbc.M300609200] [PMID: 12690099]
[http://dx.doi.org/10.1016/j.biocel.2006.03.023] [PMID: 16766221]
[http://dx.doi.org/10.1016/j.cellsig.2008.10.011] [PMID: 18992324]
[http://dx.doi.org/10.3748/wjg.15.1702] [PMID: 19360913]
[http://dx.doi.org/10.1172/JCI35073] [PMID: 18521188]
[http://dx.doi.org/10.1126/science.1156906] [PMID: 18388260]
[http://dx.doi.org/10.1038/nrc2628] [PMID: 19343034]
[http://dx.doi.org/10.1084/jem.184.4.1397] [PMID: 8879212]
[http://dx.doi.org/10.1101/gad.1549407] [PMID: 17639077]
[http://dx.doi.org/10.1016/j.tranon.2017.12.009] [PMID: 29413760]
[http://dx.doi.org/10.1074/jbc.RA118.003276] [PMID: 29853638]
[http://dx.doi.org/10.1016/S0304-3835(99)00401-2] [PMID: 10766420]
[http://dx.doi.org/10.1182/blood-2003-08-2860] [PMID: 15070705]
[PMID: 15868900]
[http://dx.doi.org/10.1186/s12885-016-2191-7] [PMID: 26915435]
[http://dx.doi.org/10.1111/j.1600-065X.2008.00706.x] [PMID: 19161426]
[http://dx.doi.org/10.1111/j.1477-2574.2009.00059.x] [PMID: 19768141]
[http://dx.doi.org/10.1158/1940-6207.CAPR-16-0209] [PMID: 27913448]
[http://dx.doi.org/10.1038/nri1184] [PMID: 12949498]
[http://dx.doi.org/10.1146/annurev.immunol.18.1.621] [PMID: 10837071]
[http://dx.doi.org/10.1084/jem.193.5.631] [PMID: 11238593]
[http://dx.doi.org/10.1016/bs.ircmb.2017.07.007] [PMID: 29305014]
[http://dx.doi.org/10.1038/ni.2060] [PMID: 21772280]
[http://dx.doi.org/10.1196/annals.1352.026] [PMID: 16387690]
[http://dx.doi.org/10.3892/ijo.18.2.257] [PMID: 11172590]
[http://dx.doi.org/10.1007/s11010-013-1930-1] [PMID: 24399465]
[http://dx.doi.org/10.3892/or.2014.3059] [PMID: 24603952]
[PMID: 22007514]
[http://dx.doi.org/10.1186/1756-9966-29-87] [PMID: 20594324]
[http://dx.doi.org/10.1007/s11010-013-1772-x] [PMID: 23943306]
[http://dx.doi.org/10.3892/or.2012.2165] [PMID: 23232982]
[http://dx.doi.org/10.1007/s10549-018-4847-2] [PMID: 29971628]
[http://dx.doi.org/10.1002/tox.22268] [PMID: 27060453]
[http://dx.doi.org/10.1007/s11010-016-2703-4] [PMID: 27084536]
[http://dx.doi.org/10.1194/jlr.R600021-JLR200] [PMID: 17202130]
[http://dx.doi.org/10.2741/3066] [PMID: 18508572]
[http://dx.doi.org/10.1158/1541-7786.MCR-07-2088] [PMID: 18567808]
[PMID: 8315568]
[http://dx.doi.org/10.1215/S1152851704001061] [PMID: 15831231]
[http://dx.doi.org/10.2174/156800908783497159] [PMID: 18288938]
[http://dx.doi.org/10.1111/bju.12452] [PMID: 24053309]
[http://dx.doi.org/10.1002/ptr.5936] [PMID: 28960541]
[http://dx.doi.org/10.1089/jir.2018.0010] [PMID: 30422744]
[http://dx.doi.org/10.1172/JCI118717] [PMID: 8647962]
[http://dx.doi.org/10.1002/cncr.10684] [PMID: 12209745]
[http://dx.doi.org/10.1038/nm0302-289] [PMID: 11875501]
[http://dx.doi.org/10.1056/NEJM200006293422603] [PMID: 10874062]
[http://dx.doi.org/10.3748/wjg.v23.i7.1171] [PMID: 28275297]
[http://dx.doi.org/10.1055/s-2005-871288] [PMID: 16142638]
[http://dx.doi.org/10.1089/jir.2005.25.733] [PMID: 16375601]
[http://dx.doi.org/10.1038/sj.onc.1203527] [PMID: 10851046]
[http://dx.doi.org/10.1038/nrc1275] [PMID: 14964307]
[http://dx.doi.org/10.1517/13543780802565791] [PMID: 19053881]
[http://dx.doi.org/10.4161/jkst.24198] [PMID: 24058801]
[http://dx.doi.org/10.3748/wjg.v22.i16.4149] [PMID: 27122665]
[http://dx.doi.org/10.1111/j.1476-5381.2010.00874.x] [PMID: 20880395]
[http://dx.doi.org/10.1016/0006-291X(89)92678-8] [PMID: 2735925]
[http://dx.doi.org/10.1016/0006-291X(92)92277-5] [PMID: 1281999]
[http://dx.doi.org/10.1084/jem.20100438] [PMID: 21098094]
[http://dx.doi.org/10.4236/pp.2013.41002]
[http://dx.doi.org/10.1016/j.bionut.2012.04.004]
[http://dx.doi.org/10.1007/s11418-015-0895-7] [PMID: 25796541]
[http://dx.doi.org/10.1080/09674845.2011.11730340] [PMID: 21950205]
[http://dx.doi.org/10.1189/jlb.0603252] [PMID: 14525967]
[http://dx.doi.org/10.3390/ijms19051355] [PMID: 29751576]
[http://dx.doi.org/10.1016/j.intimp.2011.10.013] [PMID: 22051975]
[PMID: 7515916]
[http://dx.doi.org/10.1002/jcb.22884] [PMID: 20872780]
[http://dx.doi.org/10.1016/S1567-5769(02)00139-X] [PMID: 12433061]
[http://dx.doi.org/10.1016/j.jneuroim.2018.04.018] [PMID: 29759145]
[http://dx.doi.org/10.3389/fimmu.2017.01668] [PMID: 29234325]
[http://dx.doi.org/10.7150/jca.24577] [PMID: 29805703]
[http://dx.doi.org/10.1158/1078-0432.CCR-16-0049] [PMID: 27084738]
[http://dx.doi.org/10.1016/j.canlet.2015.10.009] [PMID: 26477683]
[http://dx.doi.org/10.1056/NEJMoa1809615] [PMID: 30345906]
[http://dx.doi.org/10.3892/ol.2018.9219] [PMID: 30214551]