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Current Pharmaceutical Design

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ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

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Research Article

Preparation and Characterization of Agar Based Magnetic Nanocomposite for Potential Biomedical Applications

Author(s): Nasrullah Shah*, Tahir Zaman, Touseef Rehan, Salman Khan, Waliullah Khan, Abbas Khan and Mazhar Ul-Islam*

Volume 25, Issue 34, 2019

Page: [3672 - 3680] Pages: 9

DOI: 10.2174/1381612825666191011113109

Price: $65

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Abstract

Purpose: The purpose of the present study was to make a biocompatible agar based composite material via incorporation of appropriate additives within the agar matrix for potential applications in drug delivery and biomedical fields.

Methodology: Agar based composites were prepared by the incorporation of magnetic iron oxide nano particles, graphite and sodium aluminum as additives in different proportions within the agar matrix by a simple thermophysico- mechanical method. The as prepared agar based composites were then characterized by different techniques i.e. FTIR, SEM, TGA, XRD and EDX analyses. The FTIR peaks confirmed the presence of each component in the agar composite. SEM images showed the uniform distribution of each component in the agar composite. TGA study showed the thermal stability range of different composite sheets. XRD pattern revealed the crystallinity and EDX analysis confirmed the elemental composition of the prepared composites. The prepared agar based composites were evaluated for antimicrobial activities against three pathogenic bacterial strains Escherichia coli, Staphylococcus aureus and Klebsiella pneumonia and the result indicated efficient antimicrobial activities for all composites.

Conclusion: From the overall study, it was concluded that due to the non-toxic nature, thermal stability and excellent antibacterial properties, the prepared agar based composites can receive potential biomedical applications.

Keywords: Magnetic nanocomposite, agar, graphite, iron oxide, sodium aluminate, biomedical applications.

« Previous Next »
[1]
Abdelaziz M, Algahtani A. Processing Of Al2O3. Polym Compos 2017.
[2]
Shah N, Ul-Islam M, Khattak WA, Park JK. Overview of bacterial cellulose composites: a multipurpose advanced material. Carbohydr Polym 2013; 98(2): 1585-98.
[http://dx.doi.org/10.1016/j.carbpol.2013.08.018] [PMID: 24053844]
[3]
Park JB, Lakes RS. Composites as Biomaterials. Biomaterials 2007; 207-24.
[4]
Ahmad I, Kamal T, Khan SB, Asiri AM. An efficient and easily retrievable dip catalyst based on silver nanoparticles/chitosan-coated cellulose filter paper. Cellulose 2016; 23: 3577-88.
[http://dx.doi.org/10.1007/s10570-016-1053-4]
[5]
Ali F, Khan SB, Kamal T, Alamry KA, Asiri AM. Chitosan-titanium oxide fibers supported zero-valent nanoparticles: Highly efficient and easily retrievable catalyst for the removal of organic pollutants. Sci Rep 2018; 8(1): 6260.
[http://dx.doi.org/10.1038/s41598-018-24311-4] [PMID: 29674721]
[6]
Ali F, Khan SB, Kamal T, Alamry KA, Asiri AM, Sobahi TRA. Chitosan coated cotton cloth supported zero-valent nanoparticles: simple but economically viable, efficient and easily retrievable catalysts. Sci Rep 2017; 7(1): 16957.
[http://dx.doi.org/10.1038/s41598-017-16815-2] [PMID: 29209040]
[7]
Ali F, Khan SB, Kamal T, et al. Synthesis and characterization of metal nanoparticles templated chitosan-SiO2 catalyst for the reduction of nitrophenols and dyes. Carbohydr Polym 2018; 192: 217-30.
[http://dx.doi.org/10.1016/j.carbpol.2018.03.029] [PMID: 29691016]
[8]
Ali F, Khan SB, Kamal T, Anwar Y, Alamry KA, Asiri AM. Anti-bacterial chitosan/zinc phthalocyanine fibers supported metallic and bimetallic nanoparticles for the removal of organic pollutants. Carbohydr Polym 2017; 173: 676-89.
[http://dx.doi.org/10.1016/j.carbpol.2017.05.074] [PMID: 28732913]
[9]
Ali N. Awais, Kamal T, et al. Chitosan-coated cotton cloth supported copper nanoparticles for toxic dye reduction. Int J Biol Macromol 2018; 111: 832-8.
[http://dx.doi.org/10.1016/j.ijbiomac.2018.01.092] [PMID: 29355628]
[10]
Haider S, Kamal T, Khan SB, et al. Natural polymers supported copper nanoparticles for pollutants degradation. Appl Surf Sci 2016; 387: 1154-61.
[http://dx.doi.org/10.1016/j.apsusc.2016.06.133]
[11]
Kamal T, Ahmad I, Khan SB, Asiri AM. Agar hydrogel supported metal nanoparticles catalyst for pollutants degradation in water. Desalination Water Treat 2018; 136: 290-8.
[http://dx.doi.org/10.5004/dwt.2018.23230]
[12]
Kamal T, Ali N, Naseem AA, Khan SB, Asiri AM. Polymer nanocomposite membranes for antifouling nanofiltration. Recent Pat Nanotechnol 2016; 10(3): 189-201.
[http://dx.doi.org/10.2174/1872210510666160429145704] [PMID: 27136927]
[13]
Kamal T, Anwar Y, Khan SB, Chani MTS, Asiri AM. Dye adsorption and bactericidal properties of TiO2/chitosan coating layer. Carbohydr Polym 2016; 148: 153-60.
[http://dx.doi.org/10.1016/j.carbpol.2016.04.042] [PMID: 27185126]
[14]
Kamal T, Khan SB, Asiri AM. Synthesis of zero-valent Cu nanoparticles in the chitosan coating layer on cellulose microfibers: evaluation of azo dyes catalytic reduction. Cellulose 2016; 23: 1911-23.
[http://dx.doi.org/10.1007/s10570-016-0919-9]
[15]
Kamal T, Khan SB, Asiri AM. Nickel nanoparticles-chitosan composite coated cellulose filter paper: an efficient and easily recoverable dip-catalyst for pollutants degradation. Environ Pollut 2016; 218: 625-33.
[http://dx.doi.org/10.1016/j.envpol.2016.07.046] [PMID: 27481647]
[16]
Khan MSJ, Kamal T, Ali F, Asiri AM, Khan SB. Chitosan-coated polyurethane sponge supported metal nanoparticles for catalytic reduction of organic pollutants. Int J Biol Macromol 2019; 132: 772-83.
[http://dx.doi.org/10.1016/j.ijbiomac.2019.03.205] [PMID: 30928377]
[17]
Khan SA, Khan SB, Kamal T, Asiri AM, Akhtar K. Recent development of chitosan nanocomposites for environmental applications. Recent Pat Nanotechnol 2016; 10(3): 181-8.
[http://dx.doi.org/10.2174/1872210510666160429145339] [PMID: 27136929]
[18]
Khan SA, Khan SB, Kamal T, Yasir M, Asiri AM. Antibacterial nanocomposites based on chitosan/Co-MCM as a selective and efficient adsorbent for organic dyes. Int J Biol Macromol 2016; 91: 744-51.
[http://dx.doi.org/10.1016/j.ijbiomac.2016.06.018] [PMID: 27287771]
[19]
Khan SB, Ali F, Kamal T, Anwar Y, Asiri AM, Seo J. CuO embedded chitosan spheres as antibacterial adsorbent for dyes. Int J Biol Macromol 2016; 88: 113-9.
[http://dx.doi.org/10.1016/j.ijbiomac.2016.03.026] [PMID: 26993528]
[20]
Khan SB, Khan SA, Marwani HM, et al. Anti-bacterial PES-cellulose composite spheres: dual character toward extraction and catalytic reduction of nitrophenol. RSC Advances 2016; 6: 110077-90.
[http://dx.doi.org/10.1039/C6RA21626A]
[21]
Shah N, Claessyns F, Rimmer S, et al. Effective role of magnetic core-shell nanocomposites in removing organic and inorganic wastes from water. Recent Pat Nanotechnol 2016; 10(3): 202-12.
[http://dx.doi.org/10.2174/1872210510666160429145524] [PMID: 27784257]
[22]
AL-Oqla FM, Alothman OY, Jawaid M, Sapuan S, Es-Saheb M. Processing and properties of date palm fibers and its composites. In: eds., Biomass and bioenergy. Springer 2014; pp. 1-25.
[23]
Meng F, Zhang Y, Xiong Z, Wang G, Li F, Zhang L. Mechanical, hydrophobic and thermal properties of an organic-inorganic hybrid carrageenan-polyvinyl alcohol composite film. Compos, Part B Eng 2018; 143: 1-8.
[http://dx.doi.org/10.1016/j.compositesb.2017.12.009]
[24]
Younes HM. Photopolymerization of polymeric composites in drug delivery, tissue engineering, and other biomedical applications. In: eds., Polymer Nanocomposites in Biomedical Engineering. Springer 2019; pp. 271-97.
[25]
Yang J, Guo JL, Mikos AG, He C, Cheng G. Material processing and design of biodegradable metal matrix composites for biomedical applications. Ann Biomed Eng 2018; 46(9): 1229-40.
[http://dx.doi.org/10.1007/s10439-018-2058-y] [PMID: 29869105]
[26]
Berceli SA, Phaneuf MD, LoGerfo FW. Evaluation of a novel hirudin-coated polyester graft to physiologic flow conditions: hirudin bioavailability and thrombin uptake. J Vasc Surg 1998; 27(6): 1117-27.
[http://dx.doi.org/10.1016/S0741-5214(98)70014-X] [PMID: 9652474]
[27]
Ahmed S, Ikram S, Kanchi S, Bisetty K. Bionanocomposite materials: concept, applications, and recent advancements. In: eds., Biocomposites. Pan Stanford 2018; pp. 219-236.
[28]
Tathe A, Ghodke M, Nikalje AP. A brief review: biomaterials and their application. Int J Pharm Pharm Sci 2010; 2: 19-23.
[29]
Belay M, Nagarale RK, Verma V. Preparation and characterization of graphene-agar and graphene oxide-agar composites. J Appl Polym Sci 2017; 134: 45085.
[http://dx.doi.org/10.1002/app.45085]
[30]
Shah N, Ha JH, Park JK. Effect of reactor surface on production of bacterial cellulose and water soluble oligosaccharides by Gluconacetobacter hansenii PJK. Biotechnol Bioprocess Eng; BBE 2010; 15: 110-8.
[http://dx.doi.org/10.1007/s12257-009-3064-6]
[31]
Mir M, Ali MN, Barakullah A, et al. Synthetic polymeric biomaterials for wound healing: a review. Prog Biomater 2018; 7(1): 1-21.
[http://dx.doi.org/10.1007/s40204-018-0083-4] [PMID: 29446015]
[32]
Jumaidin R, Sapuan SM, Jawaid M, Ishak MR, Sahari J. Thermal, mechanical, and physical properties of seaweed/sugar palm fibre reinforced thermoplastic sugar palm Starch/Agar hybrid composites. Int J Biol Macromol 2017; 97: 606-15.
[http://dx.doi.org/10.1016/j.ijbiomac.2017.01.079] [PMID: 28109810]
[33]
Liu S, Zeng TH, Hofmann M, et al. Antibacterial activity of graphite, graphite oxide, graphene oxide, and reduced graphene oxide: membrane and oxidative stress. ACS Nano 2011; 5(9): 6971-80.
[http://dx.doi.org/10.1021/nn202451x] [PMID: 21851105]
[34]
Reddappa H, Suresh K, Niranjan H, Satyanarayana K. Dry sliding friction and wear behavior of Aluminum/Beryl composites. Int J Appl Eng Res 2011; 2: 502-11.
[35]
Bojić A, Purenović M, Kocić B, Perović J, Ursić-Janković J, Bojić D. The inactivation of Escherichia coli by microalloyed aluminium based composite. Facta universitatis-series: Physics. Chemistry and Technology 2001; 2: 115-24.
[36]
Gilchrist RK, Medal R, Shorey WD, Hanselman RC, Parrott JC, Taylor CB. Selective inductive heating of lymph nodes. Ann Surg 1957; 146(4): 596-606.
[http://dx.doi.org/10.1097/00000658-195710000-00007] [PMID: 13470751]
[37]
Majewski P, Thierry B. Functionalized magnetite nanoparticles-synthesis, properties, and bio-applications. Crit Rev Solid State Mater Sci 2007; 32: 203-15.
[http://dx.doi.org/10.1080/10408430701776680]
[38]
Gul S, Shah N, Arain MB, et al. Fabrication of magnetic core shell particles coated with phenylalanine imprinted polymer. Polym Test 2019; 75: 262-9.
[http://dx.doi.org/10.1016/j.polymertesting.2019.02.023]
[39]
Ul-Islam M, Ullah MW, Khan S, et al. Current advancements of magnetic nanoparticles in adsorption and degradation of organic pollutants. Environ Sci Pollut Res Int 2017; 24(14): 12713-22.
[http://dx.doi.org/10.1007/s11356-017-8765-3] [PMID: 28378308]
[40]
Alegret N, Criado A, Prato M. Recent advances of graphene-based hybrids with magnetic nanoparticles for biomedical applications. Curr Med Chem 2017; 24(5): 529-36.
[http://dx.doi.org/10.2174/0929867323666161216144218] [PMID: 27993110]
[41]
Lim JY, Yoon J, Hovde CJ. A brief overview of Escherichia coli O157:H7 and its plasmid O157. J Microbiol Biotechnol 2010; 20(1): 5-14.
[PMID: 20134227]
[42]
Kaper JB, Nataro JP, Mobley HL. Pathogenic Escherichia coli. Nat Rev Microbiol 2004; 2(2): 123-40.
[http://dx.doi.org/10.1038/nrmicro818] [PMID: 15040260]
[43]
Tong SY, Davis JS, Eichenberger E, Holland TL, Fowler VG Jr. Staphylococcus aureus infections: epidemiology, pathophysiology, clinical manifestations, and management. Clin Microbiol Rev 2015; 28(3): 603-61.
[http://dx.doi.org/10.1128/CMR.00134-14] [PMID: 26016486]
[44]
Zago CE, Silva S, Sanitá PV, et al. Dynamics of biofilm formation and the interaction between Candida albicans and methicillin-susceptible (MSSA) and -resistant Staphylococcus aureus (MRSA). PLoS One 2015; 10(4)e0123206
[http://dx.doi.org/10.1371/journal.pone.0123206] [PMID: 25875834]
[45]
Rashid T, Ebringer A. Ankylosing spondylitis is linked to Klebsiella--the evidence. Clin Rheumatol 2007; 26(6): 858-64.
[http://dx.doi.org/10.1007/s10067-006-0488-7] [PMID: 17186116]
[46]
García de la Torre M, Romero-Vivas J, Martínez-Beltrán J, Guerrero A, Meseguer M, Bouza E. Klebsiella bacteremia: an analysis of 100 episodes. Rev Infect Dis 1985; 7(2): 143-50.
[http://dx.doi.org/10.1093/clinids/7.2.143] [PMID: 3890094]
[47]
Fluit AC, Schmitz F-J, Verhoef J. Frequency of isolation of pathogens from bloodstream, nosocomial pneumonia, skin and soft tissue, and urinary tract infections occurring in European patients. Eur J Clin Microbiol Infect Dis 2001; 20(3): 188-91.
[http://dx.doi.org/10.1007/s100960100455] [PMID: 11347669]
[48]
Yuanbi Z, Zumin Q, Huang J. Preparation and analysis of Fe3O4 magnetic nanoparticles used as targeted-drug carriers. Chin J Chem Eng 2008; 16: 451-5.
[http://dx.doi.org/10.1016/S1004-9541(08)60104-4]
[49]
Fatima H, Khan K, Zia M, Ur-Rehman T, Mirza B, Haq IU. Extraction optimization of medicinally important metabolites from Datura innoxia Mill.: an in vitro biological and phytochemical investigation. BMC Complement Altern Med 2015; 15: 376.
[http://dx.doi.org/10.1186/s12906-015-0891-1] [PMID: 26481652]
[50]
Kaushik P, Goyal P. In vitro evaluation of Datura innoxia (thorn-apple) for potential antibacterial activity. Indian J Microbiol 2008; 48(3): 353-7.
[http://dx.doi.org/10.1007/s12088-008-0020-7] [PMID: 23100734]
[51]
Hwang SW, Umar A, Dar GN, Kim S, Badran R. Synthesis and characterization of iron oxide nanoparticles for phenyl hydrazine sensor applications. Sens Lett 2014; 12(1)
[52]
Díaz-Bleis D, Alvarado-Gil JJ, Martínez AI, Gómez-y-Gómez Y, Freile-Pelegrín Y. On the preparation and characterization of superparamagnetic nanoparticles with Gelidium robustum agar coating for biomedical applications. Bull Mater Sci 2018; 41: 39.
[http://dx.doi.org/10.1007/s12034-018-1546-x]
[53]
Laurent S, Bridot J-L, Elst LV, Muller RN. Magnetic iron oxide nanoparticles for biomedical applications. Future Med Chem 2010; 2(3): 427-49.
[http://dx.doi.org/10.4155/fmc.09.164] [PMID: 21426176]
[54]
Goenka S, Sant V, Sant S. Graphene-based nanomaterials for drug delivery and tissue engineering. J Control Release 2014; 173: 75-88.
[http://dx.doi.org/10.1016/j.jconrel.2013.10.017] [PMID: 24161530]
[55]
Kolaei E, Cenatus C, Tweddell R, Avis T. Antifungal activity of aluminium‐containing salts against the development of carrot cavity spot and potato dry rot. Ann Appl Biol 2013; 163: 311-7.
[http://dx.doi.org/10.1111/aab.12056]

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