摘要
背景:阿尔茨海默氏病(AD)通常伴有严重的睡眠问题和昼夜节律紊乱,这在一定程度上可归因于生物钟功能障碍。 24小时的明暗循环是生物钟最强的Zeitgeber。但是,患有AD的人通常生活在不适当的Zeitgebers光环的环境中。定时暴露于强光下可能有助于巩固AD的睡眠和昼夜节律/活动节律问题,并且可能是药物治疗的低风险替代品。 目的与方法:在本综述中,来自多个研究学科的专家总结了二十七项轻度干预研究的结果,这些研究使用腕动仪来测量AD患者的睡眠和昼夜活动。 结果:综上所述,关于有益的光效应,研究结果尚无定论。但是,考虑到的研究在可利用的光干预,研究设计和活动记录仪的使用方面有很大的不同。本文对这些问题进行了全面的批判性讨论。 结论:在互补的研究学科中融合知识可能会极大地增进我们对光对健康的生物输入的理解,并可能有助于医院,家庭和工作环境中的建筑照明设计。
关键词: 光,痴呆,活动学,睡眠,昼夜节律,体力活动.
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