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Mini-Review Article

天然醛糖还原酶抑制剂：一种非酒精性脂肪肝疾病的潜在治疗剂

卷 21, 期 6, 2020

页: [599 - 609] 页: 11

弟呕挨: 10.2174/1389450120666191007111712

价格: $65

摘要

据报道，醛糖还原酶（AR）参与非酒精性脂肪肝疾病（NAFLD）的发展。肝AR在高血糖条件下被诱导，并将过量的葡萄糖转化为脂肪果糖，这部分地促进了糖尿病啮齿动物肝细胞中脂肪的积累。另外，高血糖诱导的AR或营养诱导的AR引起过氧化物酶体增殖物激活受体（PPAR）α的转录活性的抑制和肝脏中脂解的减少，这也有助于NAFLD的发展。此外，非酒精性脂肪性肝炎（NASH）中的AR诱导可能加重肝脏的氧化应激和炎性细胞因子的表达。在这里，我们总结了有关植物来源的AR抑制剂的知识，并回顾了一些植物性AR抑制剂对啮齿类动物NAFLD / NASH的影响。天然的AR抑制剂可以至少部分地通过减轻氧化应激和炎性细胞因子表达来改善NAFLD。据报道，某些天然AR抑制剂可通过调节PPARα介导的脂肪酸氧化来减轻肝脂肪变性。在这篇综述中，我们提出天然AR抑制剂是NAFLD的潜在治疗剂。

关键词: 非酒精性脂肪肝疾病，醛糖还原酶抑制剂，过氧化物酶体增殖物激活受体α，氧化应激，炎性细胞因子。

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图形摘要

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