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Review Article

微管蛋白抑制剂与秋水仙碱的结合：从2015年到2019年的审查。

卷 27, 期 40, 2020

页: [6787 - 6814] 页: 28

弟呕挨: 10.2174/0929867326666191003154051

价格: $65

摘要

由于秋水仙碱位点的三个结构域有利于与小分子化合物结合，因此微管蛋白上的秋水仙碱位点已成为抗肿瘤药物开发的常见靶标，因此，大量的微管蛋白抑制剂与秋水仙碱结合过去几年中已经报告并评估了该站点。在这项研究中，根据2015年至2019年的文献对针对秋水仙碱位点的微管蛋白抑制剂及其作为抗肿瘤药的应用进行了综述。微管蛋白抑制剂根据结构特征分为十类，包括秋水仙碱衍生物，CA-4类似物，查尔酮类似物，香豆素类似物，吲哚杂物，喹啉和喹唑啉类似物，木脂素和鬼臼毒素衍生物，吩噻嗪类似物，N-杂环杂种等。它们中的大多数在体外和体内均显示出有效的抗肿瘤活性，包括对耐多药（MDR）细胞系的抗增殖作用和抗血管特性。在这篇综述中，详细描述了针对秋水仙碱位点的微管蛋白抑制剂的设计，合成和结构-活性关系的分析。此外，表中进一步列出了多靶点抑制剂，抗MDR化合物和在体内具有抗肿瘤活性的抑制剂，以清晰展示有效的微管蛋白抑制剂，这对药物化学研究人员可能是有益的。

关键词: 微管蛋白抑制剂，秋水仙碱位点，抗肿瘤活性，多药耐药性，多靶点，结构域。

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