Login Register Cart 0
Generic placeholder image

Pharmaceutical Nanotechnology

Editor-in-Chief

ISSN (Print): 2211-7385
ISSN (Online): 2211-7393

Back
Journal Home About Journal Editorial Board Journal Insight Current Issue Volumes/Issues
Subscribe
Opinion Article

Cerium and Yttrium Oxide Nanoparticles and Nano-selenium Produce Protective Effects Against H2O2-induced Oxidative Stress in Pancreatic Beta Cells by Modulating Mitochondrial Dysfunction

Author(s): Shima Tavoosi, Amir Hossein Baghsheikhi, Seyed Vahid Shetab-Boushehri, Mona Navaei-Nigjeh, Nazanin Namazi Sarvestani, Mohammad Yahya Karimi, Akram Ranjbar, Alireza Ebadollahi-Natanzi and Asieh Hosseini*

Volume 8, Issue 1, 2020

Page: [63 - 75] Pages: 13

DOI: 10.2174/2211738507666191002154659

Abstract

Background: Type 1 diabetes mellitus is characterized by the destruction of insulin- producing Beta cells in the pancreas. Researchers hope that islet transplantation will help to patients with insulin-dependent diabetes mellitus (IDDM). Oxidative stress is the most important challenge that beta cells face to it after isolation, and mitochondrial dysfunction is a crucial mediator in beta cells death. Hence, therapeutic approaches can shift to antioxidants through the application of nanoparticles such as cerium and yttrium oxide nanoparticles (Cer and Ytt Ox NPs) and nano-selenium (Nan Se).

Objective: This study evaluates the effects of Cer and Ytt Ox NPs and Nan Se on H2O2- induced oxidative stress in pancreatic beta cells with focus on mitochondrial dysfunction pathway.

Methods: CRI-D2 beta-cell line were pretreated with Cer Ox NPs (200 µM) + Ytt Ox NPs (0.5 µg/mL) for 3 days and/or Nan Se (0.01 µM) for 1 day. Then markers of oxidative stress, mitochondrial dysfunction, insulin and glucagon secretion were measured.

Results: We reported a decrease in H2O2-induced reactive oxygen species (ROS) level and glucagon secretion, and an increase in H2O2-reduced ATP/ADP ratio, MMP, as well as UCP2 protein expression, and insulin secretion by pretreatment of CRI-D2 cells with Cer and Ytt Ox NPs and/or Nan Se.

Conclusion: We found maximum protective effect with Cer and Ytt Ox NPs on CRI-D2 beta-cell line exposed by H2O2 for keeping beta cells alive until transplant whereas combination of Cer and Ytt Ox NPs and Nan Se had very little protective effect in this condition.

Keywords: Cerium and yttrium oxide nanoparticles, mitochondrial dysfunction, nano-selenium, oxidative stress, pancreatic beta cells, type 1 diabetes mellitus.

« Previous
Graphical Abstract

[1]
Marca V, Gianchecchi E, Fierabracci A. Type 1 diabetes and its multi-factorial pathogenesis: the putative role of NK cells. Int J Mol Sci 2018; 19(3): 794.
[http://dx.doi.org/10.3390/ijms19030794] [PMID: 29534427]
[2]
Thomakos P, Panagopoulos G, Kepaptsoglou O, Zoupas C, Mitrakou A. Which factors may affect the quality of life in patients with type 1 diabetes mellitus using the medtronic VEO continus subcunaneus insulin infusion pump? Georgian Med News 2018; 277(277): 61-7.
[PMID: 29745917]
[3]
Gamble A, Pepper AR, Bruni A, Shapiro AMJ. The journey of islet cell transplantation and future development. Islets 2018; 10(2): 80-94.
[http://dx.doi.org/10.1080/19382014.2018.1428511] [PMID: 29394145]
[4]
Mohseni Salehi Monfared SS, Larijani B, Abdollahi M. Islet transplantation and antioxidant management: a comprehensive review. World J Gastroenterol 2009; 15(10): 1153-61.
[http://dx.doi.org/10.3748/wjg.15.1153] [PMID: 19291814]
[5]
Hosseini A, Baeeri M, Rahimifard M, et al. Antiapoptotic effects of cerium oxide and yttrium oxide nanoparticles in isolated rat pancreatic islets. Hum Exp Toxicol 2013; 32(5): 544-53.
[http://dx.doi.org/10.1177/0960327112468175] [PMID: 23696423]
[6]
Hosseini A, Abdollahi M. Diabetic neuropathy and oxidative stress: therapeutic perspectives. Oxid Med Cell Longev 2013; 2013: 168039.
[http://dx.doi.org/10.1155/2013/168039] [PMID: 23738033]
[7]
Hosseini A, Abdollahi M. It is time to formulate an antioxidant mixture for management of diabetes and its complications: notice for pharmaceutical industries. Int J Pharmacol 2012; 8: 60-1.
[http://dx.doi.org/10.3923/ijp.2012.60.61]
[8]
Larijani B, Salimi M, Pourkhalili N, et al. Positive response of isolated rat pancreatic islets to IMOD; hopes for better transplant outcome and graft function. Asian J Anim Vet Adv 2011; 6: 1019-25.
[http://dx.doi.org/10.3923/ajava.2011.1019.1025]
[9]
Mohammadi M, Atashpour S, Pourkhalili N, et al. Comparative improvement in function of isolated rat Langerhans islets by various phosphodiesterase 3, 4 and 5 inhibitors. Asian J Anim Vet Adv 2011; 6: 1233-40.
[http://dx.doi.org/10.3923/ajava.2011.1233.1240]
[10]
Mohseni Salehi Monfared SS, Pournourmohammadi S. Teucrium polium complex with molybdate enhance cultured islets secretory function. Biol Trace Elem Res 2010; 133(2): 236-41.
[http://dx.doi.org/10.1007/s12011-009-8424-8] [PMID: 19533042]
[11]
Colon J, Hsieh N, Ferguson A, et al. Cerium oxide nanoparticles protect gastrointestinal epithelium from radiation-induced damage by reduction of reactive oxygen species and upregulation of superoxide dismutase 2. Nanomedicine 2010; 6(5): 698-705.
[http://dx.doi.org/10.1016/j.nano.2010.01.010] [PMID: 20172051]
[12]
Pourkhalili N, Hosseini A, Nili-Ahmadabadi A, et al. Improvement of isolated rat pancreatic islets function by combination of cerium oxide nanoparticles/sodium selenite through reduction of oxidative stress. Toxicol Mech Methods 2012; 22(6): 476-82.
[http://dx.doi.org/10.3109/15376516.2012.673093] [PMID: 22409398]
[13]
Najafi R, Hosseini A, Ghaznavi H, Mehrzadi S, Sharifi AM. Neuroprotective effect of cerium oxide nanoparticles in a rat model of experimental diabetic neuropathy. Brain Res Bull 2017; 131: 117-22.
[http://dx.doi.org/10.1016/j.brainresbull.2017.03.013] [PMID: 28373151]
[14]
Pedram S, Mohammadirad A, Rezvanfar MA, Navaei-Nigjeh M, Baeeri M, Abdollahi M. On the protection by the combination of CeO2 nanoparticles and sodium selenite on human lymphocytes against chlorpyrifos-induced apoptosis in vitro. Cell J 2015; 17(2): 361-71.
[PMID: 26199915]
[15]
Heckert EG, Karakoti AS, Seal S, Self WT. The role of cerium redox state in the SOD mimetic activity of nanoceria. Biomaterials 2008; 29(18): 2705-9.
[http://dx.doi.org/10.1016/j.biomaterials.2008.03.014] [PMID: 18395249]
[16]
Khaksar MR, Rahimifard M, Baeeri M, et al. Protective effects of cerium oxide and yttrium oxide nanoparticles on reduction of oxidative stress induced by sub-acute exposure to diazinon in the rat pancreas. J Trace Elem Med Biol 2017; 41: 79-90.
[http://dx.doi.org/10.1016/j.jtemb.2017.02.013] [PMID: 28347467]
[17]
Andreescu ES, Leiter JC, Erlichman JS. Method of neuroprotection from oxidant injury using metal oxide nanoparticles. US20100098768, 2010.
[18]
El-Demerdash FM, Nasr HM. Antioxidant effect of selenium on lipid peroxidation, hyperlipidemia and biochemical parameters in rats exposed to diazinon. J Trace Elem Med Biol 2014; 28(1): 89-93.
[http://dx.doi.org/10.1016/j.jtemb.2013.10.001] [PMID: 24188896]
[19]
Torres SK, Campos VL, Leon CG, et al. Biosynthesis of selenium nanoparticles by Pantoea agglomerans and their antioxidant activity. J Nanopart Res 2012; 14: 1236.
[http://dx.doi.org/10.1007/s11051-012-1236-3]
[20]
Shiri M, Navaei-Nigjeh M, Baeeri M, et al. Blockage of both the extrinsic and intrinsic pathways of diazinon-induced apoptosis in PaTu cells by magnesium oxide and selenium nanoparticles. Int J Nanomedicine 2016; 11: 6239-50.
[http://dx.doi.org/10.2147/IJN.S119680] [PMID: 27920530]
[21]
Ghaznavi H, Najafi R, Mehrzadi S, et al. Neuro-protective effects of cerium and yttrium oxide nanoparticles on high glucose-induced oxidative stress and apoptosis in undifferentiated PC12 cells. Neurol Res 2015; 37(7): 624-32.
[http://dx.doi.org/10.1179/1743132815Y.0000000037] [PMID: 25786672]
[22]
Fesharaki PJ, Nazari P, Shakibaie M, et al. Biosynthesis of selenium nanoparticles using Klebsiella pneumoniae and their recovery by a simple sterilization process. Braz J Microbiol 2010; 41(2): 461-6.
[http://dx.doi.org/10.1590/S1517-83822010000200028] [PMID: 24031517]
[23]
Shakibaie M, Khorramizadeh MR, Faramarzi MA, Sabzevari O, Shahverdi AR. Biosynthesis and recovery of selenium nanoparticles and the effects on matrix metalloproteinase-2 expression. Biotechnol Appl Biochem 2010; 56(1): 7-15.
[http://dx.doi.org/10.1042/BA20100042] [PMID: 20408816]
[24]
Drews G, Krippeit-Drews P, Düfer M. Oxidative stress and beta-cell dysfunction. Pflugers Arch 2010; 460(4): 703-18.
[http://dx.doi.org/10.1007/s00424-010-0862-9] [PMID: 20652307]
[25]
Zorov DB, Juhaszova M, Sollott SJ. Mitochondrial reactive oxygen species (ROS) and ROS-induced ROS release. Physiol Rev 2014; 94(3): 909-50.
[http://dx.doi.org/10.1152/physrev.00026.2013] [PMID: 24987008]
[26]
Maestre I, Jordán J, Calvo S, et al. Mitochondrial dysfunction is involved in apoptosis induced by serum withdrawal and fatty acids in the β-cell line INS-1. Endocrinology 2003; 144(1): 335-45.
[http://dx.doi.org/10.1210/en.2001-211282] [PMID: 12488362]
[27]
Armann B, Hanson MS, Hatch E, Steffen A, Fernandez LA. Quantification of basal and stimulated ROS levels as predictors of islet potency and function. Am J Transplant 2007; 7(1): 38-47.
[http://dx.doi.org/10.1111/j.1600-6143.2006.01577.x] [PMID: 17227556]
[28]
Robertson RP, Harmon JS. Pancreatic islet beta-cell and oxidative stress: the importance of glutathione peroxidase. FEBS Lett 2007; 581(19): 3743-8.
[http://dx.doi.org/10.1016/j.febslet.2007.03.087] [PMID: 17433304]
[29]
Affourtit C, Brand MD. On the role of uncoupling protein-2 in pancreatic beta cells. Biochim Biophys Acta 2008; 1777(7-8): 973-9.
[http://dx.doi.org/10.1016/j.bbabio.2008.03.022] [PMID: 18433713]
[30]
Echtay KS, Roussel D, St-Pierre J, et al. Superoxide activates mitochondrial uncoupling proteins. Nature 2002; 415(6867): 96-9.
[http://dx.doi.org/10.1038/415096a] [PMID: 11780125]
[31]
Pi J, Collins S. Reactive oxygen species and uncoupling protein 2 in pancreatic β-cell function. Diabetes Obes Metab 2010; 12(Suppl. 2): 141-8.
[http://dx.doi.org/10.1111/j.1463-1326.2010.01269.x] [PMID: 21029311]
[32]
Robson-Doucette CA, Sultan S, Allister EM, et al. β-cell uncoupling protein 2 regulates reactive oxygen species production, which influences both insulin and glucagon secretion. Diabetes 2011; 60(11): 2710-9.
[http://dx.doi.org/10.2337/db11-0132] [PMID: 21984579]
[33]
Hosseini A, Abdollahi M. Antioxidants as an appropriate approach to improve the outcome of pancreatic islet isolation: evidences from animal studies. Asian J Anim Vet Adv 2012; 7: 540-1.
[http://dx.doi.org/10.3923/ajava.2012.540.541]
[34]
Tabatabaei-Malazy O, Larijani B, Abdollahi M. A systematic review of in vitro studies conducted on effect of herbal products on secretion of insulin from Langerhans islets. J Pharm Pharm Sci 2012; 15(3): 447-66.
[http://dx.doi.org/10.18433/J32W29] [PMID: 23148894]
[35]
Hosseini A, Abdollahi M. Through a mechanism-based approach, nanoparticles of cerium and yttrium may improve the outcome of pancreatic islet isolation. J Med Hypotheses Ideas 2012; 6: 4-6.
[http://dx.doi.org/10.1016/j.jmhi.2012.03.005]
[36]
Pourkhalili N, Hosseini A, Nili-Ahmadabadi A, et al. Biochemical and cellular evidence of the benefit of a combination of cerium oxide nanoparticles and selenium to diabetic rats. World J Diabetes 2011; 2(11): 204-10.
[http://dx.doi.org/10.4239/wjd.v2.i11.204] [PMID: 22087357]
[37]
Korsvik C, Patil S, Seal S, Self WT. Superoxide dismutase mimetic properties exhibited by vacancy engineered ceria nanoparticles. Chem Commun 2007; 10(10): 1056-8.
[http://dx.doi.org/10.1039/b615134e] [PMID: 17325804]
[38]
Amin KA, Hassan MS, Awad ST, Hashem KS. The protective effects of cerium oxide nanoparticles against hepatic oxidative damage induced by monocrotaline. Int J Nanomedicine 2011; 6: 143-9.
[http://dx.doi.org/10.2147/IJN.S15308] [PMID: 21289991]
[39]
Mohammad G, Mishra VK, Pandey HP. Antioxidant properties of some nanoparticle may enhance wound healing in T2DM patient. Dig J Nanomater Biostruct 2008; 3: 159-62.
[40]
Schubert D, Dargusch R, Raitano J, Chan SW. Cerium and yttrium oxide nanoparticles are neuroprotective. Biochem Biophys Res Commun 2006; 342(1): 86-91.
[http://dx.doi.org/10.1016/j.bbrc.2006.01.129] [PMID: 16480682]
[41]
Tarnuzzer RW, Colon J, Patil S, Seal S. Vacancy engineered ceria nanostructures for protection from radiation-induced cellular damage. Nano Lett 2005; 5(12): 2573-7.
[http://dx.doi.org/10.1021/nl052024f] [PMID: 16351218]
[42]
Hosseini A, Sharifi AM, Abdollahi M, et al. Cerium and yttrium oxide nanoparticles against lead-induced oxidative stress and apoptosis in rat hippocampus. Biol Trace Elem Res 2015; 164(1): 80-9.
[http://dx.doi.org/10.1007/s12011-014-0197-z] [PMID: 25516117]

Rights & Permissions Print Cite
Article Metrics
32
2
1
© 2024 Bentham Science Publishers | Privacy Policy