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Review Article

MicroRNA在肺癌中的作用：对诊断和治疗的意义。

卷 20, 期 2, 2020

页: [90 - 101] 页: 12

弟呕挨: 10.2174/1566524019666191001113511

价格: $65

摘要

肺癌由于其高患病率，侵略性，早期诊断，缺乏有效治疗和不良预后而成为世界上导致癌症死亡的第一大原因。它还显示出较高的复发率，转移率和耐药性。所有这些问题凸显了迫切需要开发使用无创生物标记物进行疾病早期检测，转移和复发的新策略。 MicroRNA（miRNA）是一类小的非编码RNA，可转录后调控基因表达。发现这些分子在包括癌症在内的越来越多的人类疾病中异常表达。可以在血液，血清，尿液和痰等体液中检测到miRNA，这使我们朝着将其用作非侵入性生物标记物进行癌症检测和监测癌症治疗及复发的想法。发现miRNA在肺癌的发生和发展中被失调，并且可以调节肺癌细胞的增殖和侵袭。在这篇综述中，我们总结了microRNA在肺癌发生和发展中的调控作用的最新进展和发现。此外，简要讨论了microRNA在EGFR信号通路调节中的作用。

关键词: 肺癌，microRNA，生物标志物，诊断，治疗，细胞死亡，生物标志物

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