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General Review Article

止血的宿主途径调节化脓性链球菌A组致病性

卷 21, 期 2, 2020

页: [193 - 201] 页: 9

弟呕挨: 10.2174/1389450120666190926152914

价格: $65

摘要

重度化脓性链球菌（GAS）感染的标志性特征是止血失调。止血是通过促成血块形成及其溶解的事件来调节血流的主要途径。但是，许多研究已经确定了止血成分可调节GAS的存活和传播。在GAS表面已鉴定出几种蛋白质，它们可用于促进侵入宿主远端部位或调节对病原体的炎症反应。 GAS M蛋白是一种表面暴露的毒力因子，似乎是与宿主止血蛋白相互作用的主要目标。当M蛋白通过决定该病原体命运的脱落或调节蛋白水解过程释放到周围环境中时，这些相互作用介导了GAS表面和溶液中的生化事件。对与这些相互作用相关的机制的透彻了解可能会导致改变GAS致病性过程的新颖方法。

关键词: A组链球菌，止血，炎症，化脓原，病原体，M蛋白。

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图形摘要

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