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Mini-Reviews in Medicinal Chemistry

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ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

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Review Article

Hypericum spp.: An Update on the Biological Activities and Metabolic Profiles

Author(s): Mariangela Marrelli, Giancarlo Statti and Filomena Conforti*

Volume 20, Issue 1, 2020

Page: [66 - 87] Pages: 22

DOI: 10.2174/1389557519666190926120211

Price: $65

Abstract

Plants from the genus Hypericum, one genus of the Hypericaceae family, have attracted a lot of attention for their potential pharmaceutical applications. Most of the studies in the literature focus on H. perforatum L. (common St. John's wort), whose complex spectrum of bioactive compounds makes this species one of the top herbal remedies and supplements in the world. It is also important to compare the studies on other Hypericum species, both from the phytochemical and biological point of view. The aim of this review was to provide an update of most recent studies about biological investigations of plants belonging to Hypericum genus. The metabolic profiles of Hypericum spp. were also discussed in order to present a spectrum of secondary metabolites not previously identified in this genus.

Keywords: Antinociceptive activity, Hypericum spp., metabolic profiles, neurodegenerative disorder, toxicity, genus.

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