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Research Article

I半聚类鉴定阿尔茨海默氏病相关miRNA

卷 19, 期 4, 2019

页: [216 - 223] 页: 8

弟呕挨: 10.2174/1566523219666190924113737

价格: $65

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摘要

背景：越来越多的学者试图将其用作阿尔茨海默氏病（AD）和轻度认知障碍（MCI）的特定生物标记。多项研究表明，miRNA与轴突生长不良和突触结构丧失有关，两者都是AD的早期事件。 miRNA的总体丧失可能与衰老，AD发病率增加有关，也可能通过某些特定的分子机制与疾病有关。 目的：确定与阿尔茨海默氏病相关的miRNA可以帮助我们找到新的药物靶点，及早诊断。 材料和方法：我们使用基因作为连接AD和miRNA的桥梁。首先，利用蛋白质相互作用网络通过已知的AD相关基因寻找更多的AD相关基因。然后，通过miRNA与基因的相互作用获得每个miRNA与这些基因的相关性。最后，每个miRNA都可以获得代表其与AD相关性的特征向量。与其他研究不同，我们不会使用分类方法来随机识别出与AD相关的miRNA的阴性样品。在这里，我们使用半集群方法“一类SVM”。与AD相关的miRNA被认为是异常值，我们的目标是鉴定与已知与AD相关的miRNA（异常值）相似的miRNA。 结果与结论：我们鉴定了257种与AD相关的新型miRNA，并将我们的方法与SVM进行比较，该方法通过产生阴性样品而应用。我们的方法的AUC远高于SVM，我们进行了案例研究以证明我们的结果可靠。

关键词: 阿尔茨海默氏病，基因，miRNA，半集群，一类SVM，MMSE。

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