Biomimetic Nanostructures with Compositional Gradient Grown by Combinatorial Matrix-Assisted Pulsed Laser Evaporation for Tissue Engineering

doi:10.2174/0929867326666190916145455
摘要

可以控制组织再生的智能生物活性表面的制造取得了永久性进展。两种或更多种具有组成梯度的材料的薄涂层可以在固体基材上构造具有不同化学和物理特征的阵列。有了这样的智能生物平台，细胞就可以暴露于具有精确特征的组织状仿生微环境中，从而将细胞的命运导向特定的表型。我们已经引入了组合基质辅助脉冲激光蒸发（C-MAPLE）作为制造有机或无机薄且具有可变组成的纳米薄涂层的单步过程的替代方法。通过C-MAPLE可以实现两个生物分子的连续倒数梯度，离散区域显示出可调节细胞内信号传导事件的物理化学特异性。在这里，我们介绍了当前的组合激光策略和方法来制备具有组成梯度的有机和无机薄膜的重点，重点是对细胞响应性的表面影响。特别地，将讨论用生物聚合物，蛋白质和药物的薄涂层进行表面功能化的特定生物潜力。激光沉积组合工艺被认为是一种新兴的非常规技术，可以广泛应用于生产复合多层板和微图案，从而加快细胞定植和组织工程的速度。
关键词: 激光合成，仿生涂层，成分梯度，组合图，复合层，组合Maple，组织工程，纳米医学。
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DOI https://dx.doi.org/10.2174/0929867326666190916145455	Print ISSN 0929-8673
Publisher Name Bentham Science Publisher	Online ISSN 1875-533X
当代药物化学

组合基质辅助脉冲激光蒸发生长组成梯度的仿生纳米结构用于组织工程

摘要

当代药物化学

组合基质辅助脉冲激光蒸发生长组成梯度的仿生纳米结构用于组织工程

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