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Review Article

内生真菌的生物活性次生代谢产物

卷 27, 期 11, 2020

页: [1836 - 1854] 页: 19

弟呕挨: 10.2174/0929867326666190916144709

价格: $65

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摘要

背景：内生菌代表了一个复杂的微生物群落，它们定居在高等植物的无症状内部组织中。几份报告表明，内生菌通过直接产生生物活性的次生代谢产物来增强其寄主植物的适应性，这些代谢产物参与保护寄主免受草食动物和病原微生物的侵害。此外，越来越明显的是，内生菌能够生物合成具有医学重要性的“植物化学物质”，最初被认为仅由其宿主植物产生。 目的：本综述概述了内生真菌的次生代谢产物，具有明显的生物活性，涵盖了2010年至2017年之间的文献。特别着重于旨在探索这些代谢物对发现内生真菌的作用方式的研究菌类。此外，本综述严格评估了内生真菌作为生物活性“植物代谢产物”替代来源的潜力。 结果：在过去的几年中，文献中描述了几种有前途的内生真菌先导结构。在这篇综述中，概述了65种具有明显生物学活性的代谢物，主要是作为抗微生物剂和细胞毒性剂。这些代谢物中的某些已显示出高度选择性或具有新颖的作用机制，作为潜在的候选药物具有广阔的前景。 结论：内生菌是药理学重要化合物的不竭之本。此外，将来可以利用内生真菌来可持续生产生物活性“植物代谢产物”。为了实现这一目标，深入了解动态内生菌-宿主植物之间的相互作用以及内生真菌基因的起源将至关重要。

关键词: 内生菌，寄主植物，天然产物，植物代谢产物，生物活性，作用方式，先导结构。

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