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Letters in Organic Chemistry

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ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

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Letter Article

OctaGel Resin - A New PEG-PS-based Solid Support for Solid-Phase Peptide Synthesis

Author(s): Shaveer Ramkisson, Yahaya E. Jad, Anamika Sharma, Beatriz G. de la Torre* and Fernando Albericio*

Volume 16, Issue 12, 2019

Page: [935 - 940] Pages: 6

DOI: 10.2174/1570178616666190913153605

Price: $65

Abstract

OctaGel resin is a unique, highly uniformed surface-active resin. Here, we compared the performance of OctaGel with that of known resins on the market, namely polystyrene and ChemMatrix, in Solid-Phase Peptide Synthesis. The synthesis of the ‘difficult’ Aib-ACP (65-74) decapeptide showed that OctaGel has the potential to yield molecules with satisfactory purity. Given its high swelling capacity and large bead size, OctaGel also shows efficient interaction with various solvents, including those mainly used for SPPS (DMF and DCM).

Keywords: Solid-phase peptide synthesis, OctaGel resin, polystyrene resin, Chem matrix, ACP-decapeptide, SEM.

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