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Mini-Reviews in Medicinal Chemistry

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ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

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Review Article

Natural Polysaccharides with Immunomodulatory Activities

Author(s): Yue Zhao, Bocheng Yan, Zhaoyu Wang, Mingjing Li* and Wei Zhao*

Volume 20, Issue 2, 2020

Page: [96 - 106] Pages: 11

DOI: 10.2174/1389557519666190913151632

Price: $65

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Abstract

Natural polysaccharide is a kind of natural macromolecular which can be extracted from plants, fungi, algae, animals, and bacteria. The monosaccharide compositions and glucosidic bonds of polysaccharides from different origins vary substantially. Natural polysaccharides have been shown to possess complex, important and multifaceted biological activities including antitumor, anticoagulant, antioxidative, antiviral, immunomodulatory, antihyperlipidemic and antihepatotoxic activities. Their properties are mainly due to their structural characteristics. It is necessary to develop polysaccharide immunomodulators with potential for preventive or therapeutic action. The present paper summarizes the structural features, immunostimulatory activity and the immunomodulatory mechanisms of natural polysaccharides. In particular, it also provides an overview of representative natural polysaccharide immunomodulators.

Keywords: Natural polysaccharides, immunomodulator, receptor, antigen-specific, activity, structure-function relationship.

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