摘要
在文献中已经研究和报道了使用玉米醇溶蛋白来控制药物释放的各种策略,尤其是使用玉米醇溶蛋白缀合物来增强口服生物利用度和靶向递送的工程策略,这引起了最近的研究兴趣。 尽管仍受限制,但制造自组装的纳米颗粒的能力,其中所述纳米颗粒负载有提供潜在基团的官能团的感兴趣分子,可以产生基于玉米醇溶蛋白的结合物,有望作为药物递送的材料。 在当前的审查中,基于各种共轭类型讨论了最近对具有突出特征的玉米醇溶蛋白偶联物的研究。 还总结了玉米醇溶蛋白的化学缀合和鉴定的关键物理化学表征方法。 通过缀合开发基于玉米醇溶蛋白的材料的更多机会将为许多候选药物提供有希望的替代制剂。
关键词: 共轭,玉米蛋白,药物控制释放,自组装纳米颗粒,靶向。
图形摘要
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