Generic placeholder image

Micro and Nanosystems

Editor-in-Chief

ISSN (Print): 1876-4029
ISSN (Online): 1876-4037

General Research Article

A Procedural Excursion of Micro Needles for Drug Delivery Systems

Author(s): Pankaj Anand * and Neeraj Tripathi

Volume 12, Issue 3, 2020

Page: [232 - 239] Pages: 8

DOI: 10.2174/1876402911666190911143227

Abstract

Background: MEMS (Micro Electro-Mechanical System) has many applications in various fields.

Objective: Development and fabrication of micro needle for biomedical application is one of that area.

Method: Application of micro to nano-scale technology in fabrication process, yields wide range of progress and produces micro mechanical devices, which provide easy transport of biological fluids into or away from living body with less effort or pain.

Conclusion: This paper presents the excursion of solid to hollow micro needles, considering their shapes, materials, with different fabrication processes. This survey discusses the application on specific body parts and drug delivery systems. Our paper suggests that hollow tubes are most effective design for application.

Keywords: MEMS, drug delivery, micro fabrication, nano-scale technology, biological fluids, microneedle.

Graphical Abstract

[1]
Richards Grayson, A.C.; Scheidt Shawgo, R.; Li, Y.; Cima, M.J. Electronic MEMS for triggered delivery. Adv. Drug Deliv. Rev., 2004, 56(2), 173-184.
[http://dx.doi.org/10.1016/j.addr.2003.07.012] [PMID: 14741114]
[2]
Lin, L.; Pisano, A.P. Silicon-processed microneedles. J. Microelectromech. Syst., 1999, 8(1), 78-84.
[3]
Kim, Y-C.; Park, J-H.; Prausnitz, M.R. Microneedles for drug and vaccine delivery. Adv. Drug Deliv. Rev., 2012, 64(14), 1547-1568.
[http://dx.doi.org/10.1016/j.addr.2012.04.005] [PMID: 22575858]
[4]
Chen, S.H.; Li, N.N.; Chen, J. Development and experimental verification of a nonlinear hyperelastic model for microneedle-skin interactions. In: IEEE 6th International Conference on Nano/Molecular Medicine and Engineering (NANOMED), Bangkok; , 2012; pp. 61-65.
[5]
Podder, P. K.; Mallick, D.; Samajdar, D. P.; Bhattacharyya, A. Design, simulation and study of mems based micro-needles and micro-pump for biomedical applications. Des. Simul. Study MEMS Based Micro-needles Micro-pump Biomed. Appl, 2011, 1(3)
[6]
Madou, M.J. Fundamentals of Microfabrication And Nanotechnology; CRC Press: Boca Raton, FL, 2011.
[7]
Chen, Y-T. Fabrication of microneedles. J. Mar. Sci. Technol., 2010, 18, 243-248.
[8]
Ganesan, K.; Palanisamy, V. Analysis and experiment of MEMS based micropump for microfluidic application. Int. J. Advan. Research in Comp. Eng. Tech. (IJARCET), 2012, 10, 259.
[9]
Luttge, R. Integrated lithographic molding for microneedle-based devices. J. Microelectromech. Syst., 2007, 16(4), 872-884.
[10]
Mogusala, N.R.; Devadasu, V.R. Fabrication of microneedle molds and polymer based biodegradable microneedle patches: A novel method. Am. J. Drug Deliv. Therap., 2015, 2(2), 2349-7211.
[11]
McAllister, D.V.; Wang, P.M.; Davis, S.P.; Park, J.H.; Canatella, P.J.; Allen, M.G.; Prausnitz, M.R. Microfabricated needles for transdermal delivery of macromolecules and nanoparticles: fabrication methods and transport studies. Proc. Natl. Acad. Sci. USA, 2003, 100(24), 13755-13760.
[http://dx.doi.org/10.1073/pnas.2331316100] [PMID: 14623977]
[12]
Henry, S.; McAllister, D.V.; Allen, M.G.; Prausnitz, M.R. Microfabricated microneedles: A novel approach to transdermal drug delivery. J. Pharm. Sci., 1998, 87(8), 922-925.
[http://dx.doi.org/10.1021/js980042+] [PMID: 9687334]
[13]
Jin, C.Y.; Han, M.H.; Lee, S.S.; Choi, Y.H. Mass producible and biocompatible microneedle patch and functional verification of its usefulness for transdermal drug delivery. Biomed. Microdevices, 2009, 11(6), 1195-1203.
[http://dx.doi.org/10.1007/s10544-009-9337-1] [PMID: 19609679]
[14]
Park, J.H.; Allen, M.G.; Prausnitz, M.R. Biodegradable polymer microneedles: Fabrication, mechanics and transdermal drug delivery. J. Control. Release, 2005, 104(1), 51-66.
[http://dx.doi.org/10.1016/j.jconrel.2005.02.002] [PMID: 15866334]
[15]
Ji, J.; Tay, F.E.H.; Miao, J. Micro fabricated hollow micro needle array using ICP etcher. J. Phys., 2006, 34(1), 1132-1136.
[16]
Gill, H.S.; Prausnitz, M.R. Coated microneedles for transdermal delivery. J. Control. Release, 2007, 117(2), 227-237.
[PMID: 17169459]
[17]
Bariya, S.H.; Gohel, M.C.; Mehta, T.A.; Sharma, O.P. Microneedles: An emerging transdermal drug delivery system. J. Pharm. Pharmacol., 2012, 64(1), 11-29.
[http://dx.doi.org/10.1111/j.2042-7158.2011.01369.x] [PMID: 22150668]
[18]
Kim, Y.C.; Quan, F.S.; Compans, R.W.; Kang, S.M.; Prausnitz, M.R. Formulation of microneedles coated with influenza virus-like particle vaccine. AAPS PharmSciTech, 2010, 11(3), 1193-1201.
[http://dx.doi.org/10.1208/s12249-010-9471-3] [PMID: 20676947]
[19]
McAllsiter, D.V.; Cros, F.; Davis, S.P.; Matta, L.M.; Prausnitz, M.R.; Allen, M.G. Three-dimensional hollow microneedles and microtube arrays; Conf. on Solid-state Sensors and Actuators: Sendai, Japan, 1999, pp. 1098-1101.
[20]
Davis, S.P.; Martanto, W.; Allen, M.G.; Prausnitz, M.R. Hollow metal microneedles for insulin delivery to diabetic rats. IEEE Trans. Biomed. Eng., 2005, 52(5), 909-915.
[http://dx.doi.org/10.1109/TBME.2005.845240] [PMID: 15887540]
[21]
Roxhed, N.; Gasser, T.C.; Griss, P.; Holzapfel, G.A.; Stemme, G. Penetration-enhanced ultrasharp microneedles and prediction on skin interaction for efficient transdermal drug delivery. J. Microelectromech. Syst., 2007, 16, 1429-1440.
[http://dx.doi.org/10.1109/JMEMS.2007.907461]
[22]
Ma, B.; Liu, S.; Gan, Z.; Liu, G.; Cai, X.; Zhang, H.; Yang, Z. A PZT insulin pump integrated with a silicon microneedle array for transdermal drug delivery. Microfluid. Nanofluidics, 2006, 2, 417-423.
[http://dx.doi.org/10.1007/s10404-006-0083-x]
[23]
Teo, M.A.L.; Shearwood, C.; Ng, K.C.; Lu, J.; Moochhala, S. In vitro and in vivo characterization of MEMS microneedles. Biomed. Microdevices, 2005, 7(1), 47-52.
[24]
Mukerjee, E.; Collins, S.D.; Isseroff, R.R.; Smith, R.L. Microneedle array for transdermal biological fluid extraction and in situ analysis. Sens. Actuators A Phys., 2004, 114, 267-275.
[http://dx.doi.org/10.1016/j.sna.2003.11.008]
[25]
Kros, W.A. Aqueous solution of non-colloidal silicic acid and boric acid. U.S. Patent No 7,915,198. 292011.
[26]
Hsu, T-R. MEMS & Microsystems: Design, manufacture, and nanoscale engineering; John Wiley & Sons: New York, 2008.
[27]
Chandrasekaran, S.; Brazzle, J.D.; Frazier, A.B. Surface micromachined metallic microneedles. J. Microelectromech. Syst., 2003, 12(3), 281-288.
[http://dx.doi.org/10.1109/JMEMS.2003.809951]
[28]
Verbaan, F.J.; Bal, S.M.; van den Berg, D.J.; Groenink, W.H.; Verpoorten, H.; Lüttge, R.; Bouwstra, J.A. Assembled microneedle arrays enhance the transport of compounds varying over a large range of molecular weight across human dermatomed skin. J. Control. Release, 2007, 117(2), 238-245.
[http://dx.doi.org/10.1016/j.jconrel.2006.11.009] [PMID: 17196697]
[29]
Gill, H.S.; Prausnitz, M.R. Coated microneedles for transdermal delivery. J. Control. Release, 2007, 117(2), 227-237.
[http://dx.doi.org/10.1016/j.jconrel.2006.10.017] [PMID: 17169459]
[30]
Janphuang, P. Polymer based micro needle patch fabricated using microinjection moulding. MATEC Web of Conferences, 2018, 192, 01039.
[http://dx.doi.org/10.1051/matecconf/201819201039]
[31]
Davidson, M.B. Diabetes Mellitus: Diagnosis and Treatment; Saunders: Philadelphia, 1998.
[32]
Koria, H.; Dedakia, A.; Patel, G. Microneedles as novel approach for drug delivery system. Drug Deliv. Syst., 2014.
[33]
Yung, K.L.; Kang, Ch.; Liu, H.; Tam, K.F.; Ko, S.M.; Kwan, F.Y.; Lee, T.M.H. Sharp tipped plastic hollow microneedle array by microinjection moulding. J. Micromech. Microeng., 2012, 22015016
[http://dx.doi.org/10.1088/0960-1317/22/1/015016]
[34]
Roxhed, N. Penetration-enhanced ultrasharp microneedles and prediction on skin interaction for efficient transdermal drug delivery. J. Microelectromech. Syst. Journalism, 2007, 16(6), 1429-1440.
[35]
Teo, M.A.; Shearwood, C.; Ng, K.C.; Lu, J.; Moochhala, S. In vitro and in vivo characterization of MEMS microneedles. Biomed. Microdevices, 2005, 7(1), 47-52.
[http://dx.doi.org/10.1007/s10544-005-6171-y] [PMID: 15834520]
[36]
Janphuang, P. Polymer based microneedle patch fabricated using microinjec-tion moulding. MATEC Web of Conferences., 2018, 192
[37]
Gupta, J.; Denson, D.D.; Felner, E.I.; Prausnitz, M.R. Rapid local anesthesia in humans using minimally invasive microneedles. Clin. J. Pain, 2012, 28(2), 129-135.
[http://dx.doi.org/10.1097/AJP.0b013e318225dbe9] [PMID: 21712713]
[38]
Nordquist, L.; Roxhed, N.; Griss, P.; Stemme, G. Novel microneedle patches for active insulin delivery are efficient in maintaining glycaemic control: an initial comparison with subcutaneous administration. Pharm. Res., 2007, 24(7), 1381-1388.
[http://dx.doi.org/10.1007/s11095-007-9256-x] [PMID: 17387600]
[39]
Laurent, P.E.; Bonnet, S.; Alchas, P.; Regolini, P.; Mikszta, J.A.; Pettis, R.; Harvey, N.G. Evaluation of the clinical performance of a new intradermal vaccine administration technique and associated delivery system. Vaccine, 2007, 25(52), 8833-8842.
[http://dx.doi.org/10.1016/j.vaccine.2007.10.020] [PMID: 18023942]
[40]
Alarcon, J.B.; Hartley, A.W.; Harvey, N.G.; Mikszta, J.A. Preclinical evaluation of microneedle technology for intradermal delivery of influenza vaccines. Clin. Vaccine Immunol., 2007, 14(4), 375-381.
[http://dx.doi.org/10.1128/CVI.00387-06] [PMID: 17329444]
[41]
Mikszta, J.A.; Dekker, J.P., III; Harvey, N.G.; Dean, C.H.; Brittingham, J.M.; Huang, J.; Sullivan, V.J.; Dyas, B.; Roy, C.J.; Ulrich, R.G. Microneedle-based intradermal delivery of the anthrax recombinant protective antigen vaccine. Infect. Immun., 2006, 74(12), 6806-6810.
[http://dx.doi.org/10.1128/IAI.01210-06] [PMID: 17030580]
[42]
Gattiker, G.E.; Kaler, K.; Mintchev, M.P. Electronic mosquito: designing asemi-invasive microsystem for blood sampling, analysis and drug delivery applications. Microsyst. Technol., 2005, 12, 44-51.
[http://dx.doi.org/10.1007/s00542-005-0015-9]
[43]
Smart, W.H.; Subramanian, K. The use of silicon microfabrication technology in painless blood glucose monitoring. Diabetes Technol. Ther., 2000, 2(4), 549-559.
[http://dx.doi.org/10.1089/15209150050501961] [PMID: 11469618]
[44]
Jiang, J.; Moore, J.S.; Edelhauser, H.F.; Prausnitz, M.R. Intrascleral drug delivery to the eye using hollow microneedles. Pharm. Res., 2009, 26(2), 395-403.
[http://dx.doi.org/10.1007/s11095-008-9756-3] [PMID: 18979189]
[45]
Han, S.W.; Mieda, S.; Nakamura, C.; Kihara, T.; Nakamura, N.; Miyake, J. Successive detection of insulin-like growth factor-II bound to receptors on a living cell surface using an AFM. J. Mol. Recognit., 2011, 24(1), 17-22.
[http://dx.doi.org/10.1002/jmr.994] [PMID: 19953597]
[46]
Kolhar, P.; Doshi, N.; Mitragotri, S. Polymer nanoneedle-mediated intracellular drug delivery. Small, 2011, 7(14), 2094-2100.
[http://dx.doi.org/10.1002/smll.201100497] [PMID: 21695782]
[47]
Ashraf, M.W.; Tayyaba, S.; Nisar, A.; Afzulpurkar, N.; Bodhale, D.W.; Lomas, T.; Poyai, A.; Tuantranont, A. Design, fabrication and analysis of silicon hollow microneedles for transdermal drug delivery system for treatment of hemodynamic dysfunctions. Cardiovasc. Eng., 2010, 10(3), 91-108.
[http://dx.doi.org/10.1007/s10558-010-9100-5] [PMID: 20730492]
[48]
Ramasubramanian, M. K.; Barham, O. M.; Swaminathan, V. Mechanics of a mosquito bite with applications to microneedle design. Bioinsp. Biomim., 3.4, 2008.

© 2025 Bentham Science Publishers | Privacy Policy
Request history8.2.27PHP Version329msRequest Duration28MBMemory UsageGET article/{article_id}/{param?}Route
  • warninglog[18:03:19] LOG.warning: Optional parameter $article_id declared before required parameter $request i...
  • warninglog[18:03:19] LOG.warning: trim(): Passing null to parameter #1 ($string) of type string is deprecated ...
  • warninglog[18:03:19] LOG.warning: Function strftime() is deprecated in /home/alphaeurekaselec/public_html/stor...
  • Booting (102ms)time
  • Application (228ms)time
  • 1 x Application (69.11%)
    228ms
    1 x Booting (30.89%)
    102ms
    14 templates were rendered
    • articlearticle.blade.php#?blade
    • includes.article_top_bannerarticle_top_banner.blade.php#?blade
    • includes.article_referencearticle_reference.blade.php#?blade
    • export_citation_formexport_citation_form.blade.php#?blade
    • includes.article_bottom_bannerarticle_bottom_banner.blade.php#?blade
    • includes.inc_related_journalsinc_related_journals.blade.php#?blade
    • includes.inc_related_ebooksinc_related_ebooks.blade.php#?blade
    • includes.journal_rightmenujournal_rightmenu.blade.php#?blade
    • includes.journal_right_bannerjournal_right_banner.blade.php#?blade
    • layouts.appapp.blade.php#?blade
    • layouts._login_access_login_access.blade.php#?blade
    • layouts._header_header.blade.php#?blade
    • layouts._main_menu_main_menu.blade.php#?blade
    • layouts._footer_menu_footer_menu.blade.php#?blade
    uri
    GET article/{article_id}/{param?}
    middleware
    web, check_user_access
    controller
    App\Http\Controllers\ArticleController@GetArticleDetails
    namespace
    App\Http\Controllers
    where
    as
    article
    file
    app/Http/Controllers/ArticleController.php:1974-2510
    32 statements were executed, 4 of which were duplicates, 28 unique. Show only duplicated141ms
    • Connection Establishedalphaeurekaselec_live_10_06_2022UserAccessCheck.php#24
      Backtrace
      • 9. middleware::check_user_access:24
      • 10. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 11. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
    • INSERT INTO visitor_ip_address (ip_address,visitor_agent,visitor_count, created_on,updated_on) VALUES ('316600437','',1,1739988199,1739988199) ON DUPLICATE KEY UPDATE visitor_count=visitor_count + 1, updated_on=1739988199
      1.33msalphaeurekaselec_live_10_06_2022UserAccessCheck.php#24
      Backtrace
      • 11. middleware::check_user_access:24
      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 14. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 15. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
    • INSERT INTO visitor_ip_address_detail (ip_address,visitor_url,visitor_count, created_on,updated_on) VALUES ('316600437','/article/100742',1,1739988199,1739988199)
      260μsalphaeurekaselec_live_10_06_2022UserAccessCheck.php#27
      Backtrace
      • 11. middleware::check_user_access:27
      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 14. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 15. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
    • (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_trail WHERE to_ip >= 316600437 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316600437) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_corporate WHERE to_ip >= 316600437 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316600437) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_token WHERE to_ip >= 316600437 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316600437) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_trail WHERE to_ip >= 316600437 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316600437) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_corporate WHERE to_ip >= 316600437 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316600437) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_token WHERE to_ip >= 316600437 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316600437) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_trail WHERE to_ip >= 316600437 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316600437) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_corporate WHERE to_ip >= 316600437 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316600437) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_token WHERE to_ip >= 316600437 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316600437) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_trail WHERE to_ip >= 316600437 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316600437) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_corporate WHERE to_ip >= 316600437 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316600437) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_token WHERE to_ip >= 316600437 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316600437) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_trail WHERE to_ip >= 316600437 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316600437) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_corporate WHERE to_ip >= 316600437 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316600437) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_token WHERE to_ip >= 316600437 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316600437) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_disease_corporate WHERE to_ip >= 316600437 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316600437) limit 1
      18.78msalphaeurekaselec_live_10_06_2022UserAccess.php#784
      Bindings
      • 0: 316600437
      • 1: 316600437
      • 2: 316600437
      • 3: 316600437
      • 4: 316600437
      • 5: 316600437
      • 6: 316600437
      • 7: 316600437
      • 8: 316600437
      • 9: 316600437
      • 10: 316600437
      • 11: 316600437
      • 12: 316600437
      • 13: 316600437
      • 14: 316600437
      • 15: 316600437
      Backtrace
      • 14. app/Models/UserAccess/UserAccess.php:784
      • 15. middleware::check_user_access:114
      • 16. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 18. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
    • SELECT at.type_name, p.copyright, p.publisher_location,m.month,y.year, a.publish_on, a.nid article_nid,a.article_id, a.pmid, a.issue_id, a.title, a.abstract,a.podcast,a.altmetric_score,a.altmetric_url,a.kudos_url, a.page_count, a.first_page, a.elocator, a.last_page, i.publication_date, a.file_name, a.file_path, a.doi, a.is_epub,a.epub_type, a.volume_id, a.is_uploaded, a.editor_choice, a.is_epub, j.image_file_name, a.article_no, a.art_type AS article_type, a.supplementary_filename,a.html_filename,a.prc_filename,a.epub_filename, a.graph_abs_lg_filename, a.graph_abs_sm_filename, a.oa_image_lg_filename, a.oa_image_sm_filename, j.journal_banner,a.animated_abstract,a.erratum_in,a.erratum_for, (CASE WHEN a.issue_id =0 THEN j.epub_price ELSE j.price END) AS sell_price, j.epub_price, j.nid AS jour_nid, j.title AS journal_title, j.issn, j.eissn,j.journal_id, j.subtitle AS jour_subtitle, v.volume_id,v.volume_name AS volume, v.year_id, i.title AS issue, i.month_id ,i.type issue_type, j.subtitle,j.formerly_title, ac.subtitle AS epub_title,a.crossmark_enabled,a.text_mining_urls,a.license_urls,a.created, a.receivedate, a.revisedate, a.acceptdate,js.js_title FROM article a LEFT JOIN article_section ac ON a.is_epub = ac.art_sec_id LEFT JOIN journal_section js ON a.js_id = js.js_id LEFT JOIN article_type at ON a.art_type = at.art_type_id LEFT JOIN issue i ON a.issue_id = i.issue_id LEFT JOIN month m ON m.id = i.month_id LEFT JOIN volume v ON v.volume_id = a.volume_id INNER JOIN year y ON y.id = v.year_id INNER JOIN journal j ON j.journal_id = a.journal_id INNER JOIN publisher p ON p.publisher_id = j.publisher_id WHERE a.article_id=100742
      1msalphaeurekaselec_live_10_06_2022Article.php#408
      Backtrace
      • 11. app/Models/Article.php:408
      • 12. app/Http/Controllers/ArticleController.php:2515
      • 13. app/Http/Controllers/ArticleController.php:2035
      • 14. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 15. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select * from `journal` where `journal_id` = 106 limit 1
      1.07msalphaeurekaselec_live_10_06_2022Journal.php#64
      Bindings
      • 0: 106
      Backtrace
      • 14. app/Models/Journal.php:64
      • 15. app/Http/Controllers/ArticleController.php:2516
      • 16. app/Http/Controllers/ArticleController.php:2035
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select count(*) as aggregate from (select j.nid as journal_nid,j.flyer_link,j.title ,j.issn,j.eissn,j.keyword, j.journal_id as journal_id, j.subtitle, j.image_file_name,j.description,j.journal_insight_url,j.doi from `subject_journal` as `sj` inner join `journal` as `j` on `j`.`journal_id` = `sj`.`journal_id` where j.journal_status=1 and subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=106) and sj.journal_id!=106 group by `j`.`nid`) as `aggregate_table`
      810μsalphaeurekaselec_live_10_06_2022Subject.php#200
      Backtrace
      • 16. app/Models/Subject.php:200
      • 17. app/Http/Controllers/ArticleController.php:2517
      • 18. app/Http/Controllers/ArticleController.php:2035
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 20. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select j.nid as journal_nid,j.flyer_link,j.title ,j.issn,j.eissn,j.keyword, j.journal_id as journal_id, j.subtitle, j.image_file_name,j.description,j.journal_insight_url,j.doi from `subject_journal` as `sj` inner join `journal` as `j` on `j`.`journal_id` = `sj`.`journal_id` where j.journal_status=1 and subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=106) and sj.journal_id!=106 group by `j`.`nid` order by `j`.`journal_id` asc limit 10 offset 0
      680μsalphaeurekaselec_live_10_06_2022Subject.php#200
      Backtrace
      • 14. app/Models/Subject.php:200
      • 15. app/Http/Controllers/ArticleController.php:2517
      • 16. app/Http/Controllers/ArticleController.php:2035
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select count(*) as aggregate from (select v.nid as volume_id,e.nid,e.title,v.issn,v.eissn,v.isbn,v.eisbn,e.ebook_id, v.image_file_name,v.file_path,v.flyer_link,v.ebook_volume_id, v.volume_name,v.doi,v.year_id,v.introduction from `subject_ebook` as `se` inner join `ebook` as `e` on `e`.`ebook_id` = `se`.`ebook_id` inner join `ebook_volume` as `v` on `v`.`ebook_id` = `se`.`ebook_id` inner join `year` as `y` on `y`.`id` = `v`.`year_id` where subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=106) and v.ebook_status='1' and y.year > 2020 group by `v`.`nid`) as `aggregate_table`
      1.46msalphaeurekaselec_live_10_06_2022Subject.php#220
      Backtrace
      • 16. app/Models/Subject.php:220
      • 17. app/Http/Controllers/ArticleController.php:2518
      • 18. app/Http/Controllers/ArticleController.php:2035
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 20. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select v.nid as volume_id,e.nid,e.title,v.issn,v.eissn,v.isbn,v.eisbn,e.ebook_id, v.image_file_name,v.file_path,v.flyer_link,v.ebook_volume_id, v.volume_name,v.doi,v.year_id,v.introduction from `subject_ebook` as `se` inner join `ebook` as `e` on `e`.`ebook_id` = `se`.`ebook_id` inner join `ebook_volume` as `v` on `v`.`ebook_id` = `se`.`ebook_id` inner join `year` as `y` on `y`.`id` = `v`.`year_id` where subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=106) and v.ebook_status='1' and y.year > 2020 group by `v`.`nid` order by `v`.`ebook_volume_id` desc limit 10 offset 0
      1.34msalphaeurekaselec_live_10_06_2022Subject.php#220
      Backtrace
      • 14. app/Models/Subject.php:220
      • 15. app/Http/Controllers/ArticleController.php:2518
      • 16. app/Http/Controllers/ArticleController.php:2035
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select * from `keywords` where `article_id` = '100742'
      380μsalphaeurekaselec_live_10_06_2022Keywords.php#43
      Bindings
      • 0: 100742
      Backtrace
      • 13. app/Models/Keywords.php:43
      • 14. app/Http/Controllers/ArticleController.php:2519
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select * from `article_citation` where `article_id` = '100742'
      2.47msalphaeurekaselec_live_10_06_2022Article.php#1570
      Bindings
      • 0: 100742
      Backtrace
      • 13. app/Models/Article.php:1570
      • 14. app/Http/Controllers/ArticleController.php:2520
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select CONCAT_WS(' ',au.first_name, ' ', ifnull(au.initials,''), ' ', au.last_name) as authors, CONCAT(au.last_name, IFNULL(CONCAT(' ', au.initials), ''), ' ', au.first_name) AS authorsRIS, CONCAT_WS(' ',au.last_name, ' ', ifnull(au.initials,''), ' ', au.first_name) as authorsCiteAs, CONCAT_WS(' ',au.first_name, IFNULL(CONCAT(' ', au.initials), ''), IFNULL(CONCAT(' ', au.last_name), '')) as authorsmodal , `au`.*, `af`.`ror_id`, `af`.`institution`, `af`.`department`, `af`.`country`, `af`.`city`, `af`.`address`, (GROUP_CONCAT(TRIM(BOTH ', ' FROM CONCAT(ifnull(concat(af.institution,','),''), ifnull(concat(af.department,','),''), ifnull(concat(af.address,','),''), ifnull(concat(af.city,','),''), ifnull(concat(af.country,','),''), ifnull(concat(af.postal_code,','),''), ifnull(concat(af.phone,','),''), ifnull(concat(af.fax,','),''))) SEPARATOR '|')) as `author_affiliation`, (GROUP_CONCAT(TRIM(BOTH ', ' FROM CONCAT(ifnull(concat(af.web_view,','),''))) SEPARATOR '|')) as `web_view` from `author` as `au` left join `author_affiliation` as `af` on `au`.`author_id` = `af`.`author_id` where `au`.`article_id` = '100742' group by `au`.`author_id` order by `au`.`article_id` asc, `au`.`sequence` asc
      3.18msalphaeurekaselec_live_10_06_2022Author.php#86
      Bindings
      • 0: 100742
      Backtrace
      • 13. app/Models/Author.php:86
      • 14. app/Http/Controllers/ArticleController.php:2533
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select `bo`.* from `bundle_offer` as `bo` where `bo`.`bundle_status` = 'A' order by `bo`.`bundle_id` desc
      260μsalphaeurekaselec_live_10_06_2022BundleOffer.php#57
      Bindings
      • 0: A
      Backtrace
      • 13. app/Models/BundleOffer.php:57
      • 14. app/Http/Controllers/ArticleController.php:2535
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select `subtitle` from `journal` where `continues_publication_journal` = 1
      480μsalphaeurekaselec_live_10_06_2022Article.php#1960
      Bindings
      • 0: 1
      Backtrace
      • 13. app/Models/Article.php:1960
      • 14. app/Http/Controllers/ArticleController.php:2062
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • Select j.subtitle, v.volume_id as volume_id,v.year_id,y.year as year,v.volume_name, v.total_no_of_issues, i.issue_id as issue_id,i.title as issue, i.publication_date as issue_pub_date from journal j join volume v on j.journal_id = v.journal_id join issue i on v.volume_id = i.volume_id join article a on a.issue_id = i.issue_id join year y on v.year_id = y.id where j.journal_id = 106 and i.is_uploaded = 1 order by v.volume_name+0 desc, i.title+0 desc limit 1
      37.68msalphaeurekaselec_live_10_06_2022Issue.php#298
      Backtrace
      • 11. app/Models/Issue.php:298
      • 12. app/Http/Controllers/ArticleController.php:2068
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select a.nid,a.publish_on, a.pmid,a.article_id,a.doi,j.journal_id,j.subtitle,v.volume_name,a.volume_id as volume_id, a.issue_id,a.title,first_page, last_page, page_count,abstract,ifnull(is_abstract,"y"),asec.title as article_section,at.type_name as article_type_name, a.article_id as ArticleID ,is_epub,epub_price,epub_type,a.created, y.year from `article` as `a` left join `article_section` as `asec` on `asec`.`art_sec_id` = `a`.`is_epub` left join `article_type` as `at` on `at`.`art_type_id` = `a`.`art_type` left join `journal` as `j` on `j`.`journal_id` = `a`.`journal_id` inner join `volume` as `v` on `a`.`volume_id` = `v`.`volume_id` inner join `year` as `y` on `v`.`year_id` = `y`.`id` where a.article_status != "W" and a.is_epub = 1 and a.journal_id = 106 and a.is_uploaded = 1 group by `a`.`article_id` order by `a`.`publish_on` desc
      4.43msalphaeurekaselec_live_10_06_2022Article.php#528
      Backtrace
      • 13. app/Models/Article.php:528
      • 14. app/Http/Controllers/ArticleController.php:2070
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select a.nid,a.publish_on, a.pmid,a.article_id,a.doi,j.journal_id,j.subtitle,v.volume_name,a.volume_id as volume_id, a.issue_id,a.title,first_page, last_page, page_count,abstract,ifnull(is_abstract,"y"),asec.title as article_section,at.type_name as article_type_name, a.article_id as ArticleID ,is_epub,epub_price,epub_type,a.created, y.year from `article` as `a` left join `article_section` as `asec` on `asec`.`art_sec_id` = `a`.`is_epub` left join `article_type` as `at` on `at`.`art_type_id` = `a`.`art_type` left join `journal` as `j` on `j`.`journal_id` = `a`.`journal_id` inner join `volume` as `v` on `a`.`volume_id` = `v`.`volume_id` inner join `year` as `y` on `v`.`year_id` = `y`.`id` where a.article_status != "W" and a.is_epub = 4 and a.journal_id = 106 and a.is_uploaded = 1 group by `a`.`article_id` order by `a`.`publish_on` desc
      3.79msalphaeurekaselec_live_10_06_2022Article.php#528
      Backtrace
      • 13. app/Models/Article.php:528
      • 14. app/Http/Controllers/ArticleController.php:2071
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select pdf, html, epub, prc from `article_metrics` where `article_id` = 100742 limit 1
      270μsalphaeurekaselec_live_10_06_2022Article.php#744
      Bindings
      • 0: 100742
      Backtrace
      • 14. app/Models/Article.php:744
      • 15. app/Http/Controllers/ArticleController.php:2091
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from content_by_diseases where content_id = 100742 and content_type = 'article' order by status desc limit 1
      390μsalphaeurekaselec_live_10_06_2022Article.php#751
      Backtrace
      • 11. app/Models/Article.php:751
      • 12. app/Http/Controllers/ArticleController.php:2094
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select a.nid article_nid,a.title article_title,j.title journal_title from content_by_diseases cd inner join article a on a.article_id=cd.content_id inner join journal j on j.journal_id=a.journal_id where cd.pid = 283 and cd.sub_disease_id = 591 and content_id!=100742 and cd.content_type = 'article' order by rand() limit 20
      53.9msalphaeurekaselec_live_10_06_2022Article.php#769
      Backtrace
      • 11. app/Models/Article.php:769
      • 12. app/Http/Controllers/ArticleController.php:2098
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `node_meta` where `nid` = 174806 limit 1
      200μsalphaeurekaselec_live_10_06_2022Meta.php#30
      Bindings
      • 0: 174806
      Backtrace
      • 14. app/Models/Meta.php:30
      • 15. app/Http/Controllers/ArticleController.php:2101
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select `bo`.* from `bundle_offer` as `bo` where `bo`.`bundle_status` = 'A' order by `bo`.`bundle_id` desc
      210μsalphaeurekaselec_live_10_06_2022BundleOffer.php#57
      Bindings
      • 0: A
      Backtrace
      • 13. app/Models/BundleOffer.php:57
      • 14. app/Http/Controllers/ArticleController.php:2108
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `tbl_ht_submission` as `h` where `h`.`subtitle` = 'MNS' and (h.proposal_closing_date = 0 OR TO_DAYS(FROM_UNIXTIME(h.proposal_closing_date)) >= TO_DAYS(NOW())) order by `h`.`manuscript` asc
      240μsalphaeurekaselec_live_10_06_2022Article.php#2025
      Bindings
      • 0: MNS
      Backtrace
      • 13. app/Models/Article.php:2025
      • 14. app/Http/Controllers/ArticleController.php:2112
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as total_count, content_type_access_id as access_type from journal_access where content_type_id = '100742' and content_type = 'a' and ( (from_date <= CURDATE() and to_date >= CURDATE() and perpetual= 0) or (from_date is null and to_date is null and perpetual= 1) )
      420μsalphaeurekaselec_live_10_06_2022ContentAccess.php#647
      Backtrace
      • 11. app/Models/ContentAccess.php:647
      • 12. app/Http/Controllers/ArticleController.php:2186
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `article` where `first_page` < '232' and is_uploaded = 1 and issue_id = 10170 order by cast(first_page as SIGNED) desc limit 1
      550μsalphaeurekaselec_live_10_06_2022Article.php#1819
      Bindings
      • 0: 232
      Backtrace
      • 14. app/Models/Article.php:1819
      • 15. app/Http/Controllers/ArticleController.php:2470
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `article` where `last_page` > '239' and is_uploaded = 1 and issue_id = 10170 order by cast(first_page as SIGNED) asc limit 1
      520μsalphaeurekaselec_live_10_06_2022Article.php#1831
      Bindings
      • 0: 239
      Backtrace
      • 14. app/Models/Article.php:1831
      • 15. app/Http/Controllers/ArticleController.php:2472
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select `language_id` from `multilanguage` where `short_code` = 'en'
      190μsalphaeurekaselec_live_10_06_2022ArticleController.php#2497
      Bindings
      • 0: en
      Backtrace
      • 14. app/Http/Controllers/ArticleController.php:2497
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:206
    • select `source_lang_label`, `target_lang_label` from `multilanguage_labels` where `target_lang_id` = 1
      240μsalphaeurekaselec_live_10_06_2022MultiLanguage.php#23
      Bindings
      • 0: 1
      Backtrace
      • 13. app/Models/MultiLanguage.php:23
      • 14. app/Http/Controllers/ArticleController.php:2498
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select `id` from `multilanguage_article` where `article_id` = 100742 limit 1
      2.55msalphaeurekaselec_live_10_06_2022ArticleController.php#2506
      Bindings
      • 0: 100742
      Backtrace
      • 16. app/Http/Controllers/ArticleController.php:2506
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • 20. vendor/laravel/framework/src/Illuminate/Routing/Route.php:206
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` inner join `journal` as `j` on `j`.`journal_id` = `bd`.`content_id` where `b`.`banner_journal` = 1 and `bd`.`content_type` = 'J' and `bd`.`content_id` = 106 and `b`.`banner_from_date` <= 1739988199 and `b`.`banner_to_date` >= 1739988199 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      1.11msalphaeurekaselec_live_10_06_2022Banner.php#95
      Bindings
      • 0: 1
      • 1: J
      • 2: 106
      • 3: 1739988199
      • 4: 1739988199
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:95
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` inner join `journal` as `j` on `j`.`journal_id` = `bd`.`content_id` where `b`.`banner_journal` = 1 and `bd`.`content_type` = 'J' and `bd`.`content_id` = 106 and `b`.`banner_from_date` <= 1739988199 and `b`.`banner_to_date` >= 1739988199 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      1.07msalphaeurekaselec_live_10_06_2022Banner.php#95
      Bindings
      • 0: 1
      • 1: J
      • 2: 106
      • 3: 1739988199
      • 4: 1739988199
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:95
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select count(*) as aggregate from `uc_cart_products` where cart_id='eb73a9fd5be3d3df7a3a643388d8b9a3'
      200μsalphaeurekaselec_live_10_06_2022Cart.php#271
      Backtrace
      • 15. app/Models/Cart.php:271
      • 16. view::layouts._header:260
      • 18. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 20. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    App\Models\MultiLanguage
    1MultiLanguage.php#?
        _token
        RvvzqIpZ5eKQy3oWmr1wasKWdHX9AF7nMhIaxQLO
        uc_cart_id
        eb73a9fd5be3d3df7a3a643388d8b9a3
        _previous
        array:1 [ "url" => "http://alpha.eurekaselect.com/article/100742" ]
        _flash
        array:2 [ "old" => [] "new" => [] ]
        PHPDEBUGBAR_STACK_DATA
        []
        path_info
        /article/100742
        status_code
        200
        
        status_text
        OK
        format
        html
        content_type
        text/html; charset=UTF-8
        request_query
        []
        
        request_request
        []
        
        request_headers
        0 of 0
        array:9 [ "cookie" => array:1 [ 0 => "wayfindertarget=eyJpdiI6Ikhhb2NCRHJWUVlwZU1TbVBicTZtV3c9PSIsInZhbHVlIjoiR08rUi94SWk5WjZPa2duN1ppOG4wY2JSbHhLcjRQQ1lZM2N5amdaR1VZaFAzcUg5LzgzZi94RWp1Y0hxdzJrMGNYZnJ2YktieGV4YThNQnQzYVMrOGc9PSIsIm1hYyI6ImJmYjlhM2UzMTJkNDE1OGMwZDRmYmU2NzBlZjZmZTFjNWQyMDdlNDRmMDBlODViY2UxYTRiZWNlYjgzZDNjZWMiLCJ0YWciOiIifQ%3D%3Dwayfindertarget=eyJpdiI6Ikhhb2NCRHJWUVlwZU1TbVBicTZtV3c9PSIsInZhbHVlIjoiR08rUi94SWk5WjZPa2duN1ppOG4wY2JSbHhLcjRQQ1lZM2N5amdaR1VZaFAzcUg5LzgzZi94RWp1Y0hxdzJrMGNY" ] "accept-encoding" => array:1 [ 0 => "gzip, deflate" ] "accept" => array:1 [ 0 => "text/html,application/xhtml+xml,application/xml;q=0.9,image/avif,image/webp,image/apng,*/*;q=0.8,application/signed-exchange;v=b3;q=0.7" ] "user-agent" => array:1 [ 0 => "Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)" ] "upgrade-insecure-requests" => array:1 [ 0 => "1" ] "cache-control" => array:1 [ 0 => "no-cache" ] "pragma" => array:1 [ 0 => "no-cache" ] "connection" => array:1 [ 0 => "keep-alive" ] "host" => array:1 [ 0 => "alpha.eurekaselect.com" ] ]
        request_cookies
        0 of 0
        array:1 [ "wayfindertarget" => null ]
        response_headers
        0 of 0
        array:5 [ "content-type" => array:1 [ 0 => "text/html; charset=UTF-8" ] "cache-control" => array:1 [ 0 => "no-cache, private" ] "date" => array:1 [ 0 => "Wed, 19 Feb 2025 18:03:19 GMT" ] "set-cookie" => array:2 [ 0 => "XSRF-TOKEN=eyJpdiI6ImtXVHl4V0ZRTjBUTVBraG9UK2Ura2c9PSIsInZhbHVlIjoiVGtLNmdNeE5TYllBZGRqU3NJTjQvR3A2TndteXpUaEZNUHpnRy9YY0lMcXVZUzg3OTRVcDJsQUVGZTA2SCt2SnR2MHI0VERVa1prTmNmYXZLUEVteURDVWtNRmZZR0xOWFZvUy9aMjY0VE9IdzB3dmV0VFRhemZMM1BUZFRxTDUiLCJtYWMiOiJlMDUyYmZmNzE5NDExY2MzM2NkODJmODhmYmQyMzc5YzlmMTU4YzhkYzAzNTJhNTg3YmVlNjlkNGQwZjQ2MjA3IiwidGFnIjoiIn0%3D; expires=Sat, 22 Feb 2025 06:03:19 GMT; Max-Age=216000; path=/; secure; samesite=laxXSRF-TOKEN=eyJpdiI6ImtXVHl4V0ZRTjBUTVBraG9UK2Ura2c9PSIsInZhbHVlIjoiVGtLNmdNeE5TYllBZGRqU3NJTjQvR3A2TndteXpUaEZNUHpnRy9YY0lMcXVZUzg3OTRVcDJsQUVGZTA2SCt2SnR2MHI0V" 1 => "alphaeurekaselectnet_session=eyJpdiI6IjgzQkJkb3REZ1FQdiswZi9RT3RPVlE9PSIsInZhbHVlIjoielBraXFManV3OVFUem9TamYwbVlSV3ZpUmJYK1k4SU1Eby8wdVo1RnAycEdXemlmbVJrclhkWVhoUmo2RGc4UjNWUVFySWtDcmNSRk0vL1dXS0crUy9wYWFBNHhaMGNmWjRibEtSVm5UVnV4eDF5SWp5VmtVVjd6TmtienpkTEwiLCJtYWMiOiIyOTk4OGE1OWQ1YjliMWEyYzllODkyZWFiNDJhOTgzYTU3YzNmMGJlN2FkZWNiZjJlMmUwOGY4MWFkOGQ3YjFmIiwidGFnIjoiIn0%3D; path=/; secure; httponly; samesite=laxalphaeurekaselectnet_session=eyJpdiI6IjgzQkJkb3REZ1FQdiswZi9RT3RPVlE9PSIsInZhbHVlIjoielBraXFManV3OVFUem9TamYwbVlSV3ZpUmJYK1k4SU1Eby8wdVo1RnAycEdXemlmbVJrclhkWVh" ] "Set-Cookie" => array:2 [ 0 => "XSRF-TOKEN=eyJpdiI6ImtXVHl4V0ZRTjBUTVBraG9UK2Ura2c9PSIsInZhbHVlIjoiVGtLNmdNeE5TYllBZGRqU3NJTjQvR3A2TndteXpUaEZNUHpnRy9YY0lMcXVZUzg3OTRVcDJsQUVGZTA2SCt2SnR2MHI0VERVa1prTmNmYXZLUEVteURDVWtNRmZZR0xOWFZvUy9aMjY0VE9IdzB3dmV0VFRhemZMM1BUZFRxTDUiLCJtYWMiOiJlMDUyYmZmNzE5NDExY2MzM2NkODJmODhmYmQyMzc5YzlmMTU4YzhkYzAzNTJhNTg3YmVlNjlkNGQwZjQ2MjA3IiwidGFnIjoiIn0%3D; expires=Sat, 22-Feb-2025 06:03:19 GMT; path=/; secureXSRF-TOKEN=eyJpdiI6ImtXVHl4V0ZRTjBUTVBraG9UK2Ura2c9PSIsInZhbHVlIjoiVGtLNmdNeE5TYllBZGRqU3NJTjQvR3A2TndteXpUaEZNUHpnRy9YY0lMcXVZUzg3OTRVcDJsQUVGZTA2SCt2SnR2MHI0V" 1 => "alphaeurekaselectnet_session=eyJpdiI6IjgzQkJkb3REZ1FQdiswZi9RT3RPVlE9PSIsInZhbHVlIjoielBraXFManV3OVFUem9TamYwbVlSV3ZpUmJYK1k4SU1Eby8wdVo1RnAycEdXemlmbVJrclhkWVhoUmo2RGc4UjNWUVFySWtDcmNSRk0vL1dXS0crUy9wYWFBNHhaMGNmWjRibEtSVm5UVnV4eDF5SWp5VmtVVjd6TmtienpkTEwiLCJtYWMiOiIyOTk4OGE1OWQ1YjliMWEyYzllODkyZWFiNDJhOTgzYTU3YzNmMGJlN2FkZWNiZjJlMmUwOGY4MWFkOGQ3YjFmIiwidGFnIjoiIn0%3D; path=/; secure; httponlyalphaeurekaselectnet_session=eyJpdiI6IjgzQkJkb3REZ1FQdiswZi9RT3RPVlE9PSIsInZhbHVlIjoielBraXFManV3OVFUem9TamYwbVlSV3ZpUmJYK1k4SU1Eby8wdVo1RnAycEdXemlmbVJrclhkWVh" ] ]
        session_attributes
        0 of 0
        array:5 [ "_token" => "RvvzqIpZ5eKQy3oWmr1wasKWdHX9AF7nMhIaxQLO" "uc_cart_id" => "eb73a9fd5be3d3df7a3a643388d8b9a3" "_previous" => array:1 [ "url" => "http://alpha.eurekaselect.com/article/100742" ] "_flash" => array:2 [ "old" => [] "new" => [] ] "PHPDEBUGBAR_STACK_DATA" => [] ]
        ClearShow all
        Date ↕MethodURLData
        #12025-02-19 18:03:19GET/article/100742314321