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Review Article

锌和铜在胰岛素抵抗和糖尿病中的作用

卷 27, 期 39, 2020

页: [6643 - 6657] 页: 15

弟呕挨: 10.2174/0929867326666190902122155

价格: $65

摘要

2型糖尿病（T2DM）的患病率在国际上正在不断增长。因此，预防，诊断和控制胰岛素抵抗和T2DM的重要性日益增加。有人提出导致胰岛素抵抗和糖尿病及其并发症的机制包括大量摄入精制且能量丰富的食物，据推测这与微量元素（如锌（Zn），硒（Se））的摄入不足有关。 ，铬（Cr）和铜（Cu），它们对于各种生物过程至关重要。本文的目的是强调Zn，Se和Cu在T2DM中的作用。当锌，硒和铜缺乏时，糖尿病似乎很普遍，这可能是由于精制食品摄入过多所致。文献检索是在PubMed和Scopus进行的，并补充了相关文章的参考列表和Google Scholar搜索。我们对所有相关的引文进行了严格的评估，包括英语的评论和研究论文。使用的搜索词包括Zn，Cu，糖尿病和糖尿病。研究表明，Zn，Se和Cu参与糖尿病的发病机制，但是这些微量元素可能具有过量的毒性。锌似乎可以激活参与细胞信号传导的关键分子，从而维持葡萄糖的体内稳态。锌还调节胰岛素受体，延长胰岛素的作用，并促进健康的脂质分布。过量的铜会产生氧化应激，这是T2DM发作和发展的一个因素。锌和铜代谢异常似乎伴有，也可能导致糖尿病并发症。

关键词: 锌，铜，糖尿病，微量元素，金属，2型糖尿病。

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